Research topic 1. Basic investigative research
We are looking for new concepts in immuno-micro-environmental interactions by studying lymphoid organs (bone marrow, spleen, lymph nodes) and tissues (barrier surfaces, such as skin or respiratory surfaces) in mice and whenever possible in humans. We study the development of the immune system, regulatory networks and effector functions in the context of infectious diseases, inflammation and cancer. We propose new models recapitulating the relevant molecular networks.
For example, we have shown that lymphatic endothelial cells create a niche for a subset of lymph node macrophages involved in the anti-pathogenic and anti-cancer immune response (Camara et al. Immunity, 2019). We now extend the analysis to other organs and investigate the functional importance of these niches for different cell types.
Publications on this topic:
Sponsel, Guo, Hamzam, Lavanant, Pérez-Riverón, Partiot, Muller, Rottura, Gaudin, Hauck, Titz, Flacher, Römer, Mueller (2023) Pseudomonas aeruginosa LecB suppresses immune responses by inhibiting transendothelial migration. EMBO Reports, doi: 10.15252/embr.202255971
Cousin, Perez, Payne, Voll, Rizzi, Mueller, Warnatz (2023) Lymphoid stromal cells – potential implications for the pathogenesis of CVID, Frontiers in Immunology, doi: 10.3389/fimmu.2023.1122905
Camara, Lavanant, Abe, Desforges, Alexandre, Girardi, Igamberdieva, Asano, Tanaka, Hehlgans, Pfeffer, Pfeffer, Mueller, Stein, Mueller (2022) CD169+ macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling, PNAS USA, doi: 10.1073/pnas.2108540119
Madel, Ibáñez, Ciucci, Halper, Topi, Garchon, Rouleau, Mueller, Peyrin-Biroulet, Moulin, Blin-Wakkach, Wakkach (2021) Osteoclasts contribute to early development of chronic inflammation by promoting dysregulated hematopoiesis and myeloid skewing. BioRxiv, doi: 10.1101/2020.12.09.418137
Mueller, Camara, Flacher (2020) The sinusoidal microenvironment regulates the niche and the differentiation of lymph node macrophages (in French). Med/Sci (Paris) 36: 835-838 (doi: 10.1051/medsci/2020148)
Camara, Cordeiro, Alloush, Sponsel, Chypre, Onder, Asano, Tanaka, Yagita, Ludewig, Flacher, Mueller (2019) Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 50: 1467-1481 (doi: 10.1016/j.immuni.2019.05.008)