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Basic investigative research

We are looking for new concepts in immuno-micro-environmental interactions by studying lymphoid organs and tissues (skin) in mice and in ex vivo or reconstructed human tissues. We study the underlying mechanisms and propose new models recapitulating the relevant molecular networks.

For example, we have recently shown that lymphatic endothelial cells create a niche for a subtype of lymph node macrophages involved in the anti-pathogenic and anti-cancer immune response.

Publications:

Mueller et al. (2020) Le microenvironnement sinusoïdal contrôle la mise en place et la différenciation des macrophages ganglionnaires. Med Sci (Paris) 36: 835-838 (doi: 10.1051/medsci/2020148)

Camara et al. (2019) Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche. Immunity 50: 1467-1481 (doi: 10.1016/j.immuni.2019.05.008)

CXCL13, CD35 stromal cells and B220 cells in a murin lymph node visualized by light sheet microscopy