We study the functional relevance of interactions between immune cells and their immediate environment in health and disease. In this context, we focus on the triad between innate immune cells (macrophages and dendritic cells), adaptive immune cells (T and B cells) and the stroma (mesenchymal cells, endothelial cells, epithelial cells and neurons).
The stroma constantly provides information to local immune cells for homeostasis and controls their reactivity to pathogens and autoantigens.
The following question arises: are diseases caused by a dysfunction of the immune system or, conversely, does the immunopathology reflect a dysfunction of other cells in the tissue? We believe that tissues create or influence immunopathology in many chronic inflammatory diseases, autoimmunity or cancer.
In this general context, our research is structured around two main axes: (1) fundamental investigative research and (2) disease modelling and therapeutic research.