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ARN

RNA architecture and reactivity

Recruitment

Postdoc en biophysique et biologie structurale de l’ARN (H/F)

Fixed-term contract,Researcher
The candidate will be in charge of studying the structure of a non-coding RNA involved in neurodegenerative diseases as well as its interactions with different ligands that could potentially interfere with its biological function. The project will be conducted in collaboration with the Institut de Recherches Servier.
Send your Application before : 2023.04.24
Offer published on this site from 2023.03.28 to 2023.04.24
ARN

Research engineer M/F in microbiology and molecular biology

Fixed-term contract
We are looking for a research engineer to analyzing the modifications of the ribosomal RNAs of Staphylococcus aureus under different stress conditions encountered during infections. This mapping will be carried out using a combination of innovative methodologies, including mass spectrometry, high-throughput sequencing, and cryo-electron microscopy. The impact on translation of the variations in rRNA modifications will be analyzed using an in vitro translation system. Mutations in the corresponding modifying enzymes will be performed to analyze their functions in the physiology and pathogenicity of S. aureus.
Send your Application before : 2023.03.20
Offer published on this site from 2023.02.27 to 2023.03.20
ARN

Position post-doctorale biologie moleculaire et structurale à Strasbourg (H/F)

CDD,Chercheur / Chercheuse
Le contrat post-doctoral de 24 mois est financé par l' ANR. Le projet vise à développer de nouveaux composés antibactériens en ciblant la poche hydrophobe de l'anneau de réplication. Dans ce but, le projet suit deux stratégies développées simultanément et en combinaison, toutes deux soutenues par des données préliminaires innovantes: (1) une approche de conception de médicaments basée sur les fragments (FBDD) et (2) une approche basée sur l'inhibition covalente ciblée (TCI). Les missions attachées à ce poste concernent la production et la purification de molécules biologiques, l'analyse de leurs interactions avec des ligands spécifiques (SPR, ITC, QMS, SwitchSense), l'analyse structurale des complexes formés (cristallogenèse et résolution de structures), l'évaluation des effets antibactériens des ligands développés (pénétration, quantification, MIC, MCB...). Les missions seront menées en étroite collaboration avec les partenaires du projet.
Send your Application before : 2023.02.28
Offer published on this site from 2023.02.27 to 2023.02.28
ARN

Postdoc (M/F) in biophysics and structural biology of protein/RNA interactions

Fixed-term contract,Researcher
The candidate will be in charge of studying the structure of the HIV-1 Pr55Gag precursor in association with a genomic RNA fragment containing all the necessary signals for genome-specific packaging (Psi) by cryo-EM and X-ray crystallography. We also plan to obtain the structure of the Pr55Gag-Psi complex in the presence of cellular and viral ligands of the p6 domain of Pr55Gag by the same methods.
Send your Application before : 2022.12.1
Offer published on this site from 2022.11.2 to 2022.11.23
ARN

Postdoc (M/F) in RNA biophysics and structural biology

Employment,Researcher
We are looking for a post-doctoral fellow in Structural Biology to participate in a research programme within the team "Structure and Dynamics of Biomolecular Machines" led by Eric Ennifar. The candidate will be in charge of studying the structure of a long non-coding RNA involved in solid cancers, as well as characterizing its interaction with potential partners (proteins, RNPs) in order to identify its mechanism of action and ways to interfere with its biological role.
Send your Application before : 2022.09.21
Offer published on this site from 2022.09.1 to 2022.09.30
ARN

Doctorate (M/F) for the study of Tau protein translation during Alzheimer’s disease

PhD
We are looking for a PhD student in Molecular Biology to participate in a research programme. The thesis project will focus on the study of the translation of the messenger RNA encoding the Tau protein. The study will include the use of cell-free translation extracts prepared from several cell types relevant to Alzheimer's disease. In particular, the project will focus on the synthesis of N-terminally shorter variants of the Tau protein.
Send your Application before : 2022.08.30
Offer published on this site from 2022.08.16 to 2022.08.30
ARN

PhD student (M/F) in molecular biology for the development of depollution enzymes by directed evolution and functional screening in microfluidic systems

PhD
D. student (M/F) for the development of depollution enzymes by directed evolution and functional screening in microfluidic systems. The thesis work will be carried out within the "Digital RNA Biology" team (Institute of Molecular and Cellular Biology, Strasbourg). To do this, two complementary strategies will be used in parallel, in close collaboration with the team of Prof. Stéphane Vuilleumier (University of Strasbourg). Firstly, bacteria from samples taken from sites contaminated by fluorinated compounds will be individualised in water-in-oil droplets of a few picolitres containing a minimum synthetic culture medium supplemented with the fluorinated compound to be degraded and used as a carbon source. Thus, the ability of the organism in the droplet to degrade the target compound will result not only in its growth, but also in the release of fluoride. The latter will be detected by an RNA molecular probe recently developed by the team, which converts the presence of fluoride ions into fluorescence emission.
Send your Application before : 2022.06.15
Offer published on this site from 2022.05.23 to 2022.06.15
ARN

Post-doctoral fellow in structural biology and biochemistry

Fixed-term contract,Researcher
We are looking for a motivated post-doctoral researcher to participate in a research program (36-months contract) which will be conducted between the team “Viral ribonucleoproteins, incorporation of the genome and assembly” at UPR9002 CNRS (IBMC) and the “Chromatin stability and DNA mobility” team at UMR 7104 CNRS-U 1258 Inserm (IGBMC). The research project consists in obtaining the structure of the Pr55Gag precursor of HIV-1 in association with the genomic RNA fragment containing all the signals necessary for the specific encapsidation of the genome (Psi) by cryo-EM and X-ray crystallography. We also plan to obtain the structure of the Pr55Gag-Psi complex in the presence of the cellular and viral ligands of the p6 domain of Pr55Gag by the same methods.
Send your Application before : 2022.03.8
Offer published on this site from 2022.02.15 to 2022.03.8
ARN

Poste d’assistant-e ingénieur-e H/F en biologie moléculaire et microbiologie

CDD
Notre unité recherche un assistant-e ingénieur-e H/F en biologie moléculaire et microbiologie. La mission consistera (i) à mettre en œuvre dans le cadre de protocoles bien établis, les techniques de base de la biologie pour la préparation du matériel biologique, ainsi qu'à (ii) apporter une aide pour l'organisation interne de l'équipe (préparation de tampons, commandes, suivi des équipements du laboratoire).
Send your Application before : 2022.03.7
Offer published on this site from 2022.02.15 to 2022.03.7
ARN

Post-doctoral position (M/F) in cellular biology and signalling pathways

Fixed-term contract
We are currently inviting applications from enthusiastic post-doctoral candidates to participate in a research project (2-years position) conducted in a mixed public/private environment between a CNRS team and the Adisseo Company. Previously, a comparative study identified a set of new genes activated during stress situations conserved between different species. The research program centers on the characterization of cell signaling pathways controlling this genetic program and participating in the mechanisms of resistance or adaptation to stress.
Send your Application before : 2022.02.28
Offer published on this site from 2022.01.19 to 2022.02.28
ARN

Ingénieur(e) (H/F) d’Etude pour la Sélection d’Aptamères par Criblage Microfluidique

CDD
L'équipe « Biologie Digitale de l'ARN » de l'unité « Architecture et Réactivité de l'ARN » (UPR 9002 du CNRS, Institut de Biologie Moléculaire et Cellulaire) de Strasbourg, recherche un/une ingénieur(e) d'étude dans le cadre d'un projet de Recherche et Développement en collaboration avec l'entreprise Novaptech située à Bordeaux.
Send your Application before : 2022.01.25
Offer published on this site from 2022.01.10 to 2022.01.25
ARN

Research Scientist M/F in cellular and molecular virology

Fixed-term contract,Researcher
The project will consist in studying the innate immune response during infection of human cells, mosquitoes and ticks by the Zika virus (ZIKV) and tick-borne encephalitis virus (TBEV). More specifically, the aim will be to characterize the interactome of the viral RNA replication intermediate in order to identify new factors in antiviral response. Mass spectrometry and high throughput sequencing approaches will be implemented in these infection models.
Send your Application before : 2022.01.18
Offer published on this site from 2021.11.15 to 2022.01.18
ARN

Researcher position M / F in microbiology and molecular biology

Fixed-term contract,Researcher
The mission of the project will consist in the analysis of RNA modifications (mainly tRNA and rRNA) in different strains of Staphylococcus aureus and in different stress conditions encountered during infections. This mapping will be performed using innovative methodologies, including mass spectrometry and high-throughput sequencing. The impact of variations in the epitranscriptome on the translation process and on the decoding rules will be analyzed at global scale by means of "ribosome profiling" and in details by in vitro translation systems. Based on the obtained results, mutations in key modifying enzymes will be analyzed for their function in the physiology and pathogenicity of S. aureus.
Send your Application before : 2021.11.18
Offer published on this site from 2021.11.9 to 2021.11.18
ARN

Post-doctoral fellow (M/F) in molecular biology or chemobiology

Fixed-term contract,Researcher
The droplet microfluidic systems used by the "Digital RNA Biology" team (Institute of Molecular and Cellular Biology, Strasbourg) allow the production and manipulation (e.g., controlled melting, sorting) of water-in-oil microdroplets of a few picolitres in size and very homogeneous in size at a rate of several thousand events per second. The present project will aim to use biomolecule capture technology to coat the inner surface of the droplets with synthetic RNA motifs. This approach will also allow the identification of molecules capable of interfering with the RNA/protein interaction.
Send your Application before : 2021.11.4
Offer published on this site from 2021.10.25 to 2021.11.4
ARN

Researcher position M / F in cell biology and host-pathogenic bacteria interaction

Fixed-term contract,Researcher
The mission of the project will consist in analyzing the function of regulatory RNAs of Staphylococcus aureus in an infectious context. In particular, the project will require the development and use of eukaryotic cells (i.e. immune cells) and mouse models for the study of host-pathogenic bacteria interactions. Different high-throughput sequencing approaches will be used to analyze RNA expression in these different infection models.
Send your Application before : 2021.11.22
Offer published on this site from 2021.10.25 to 2021.11.22
ARN