Immune-microenvironment interactions in health and disease

In order to model human diseases in an effort to provide personalised medicine, the laboratory reconstructs organs in vitro, such as human skin.

Publications:

Muller et al. (2021) Modélisation tridimensionnelle in vitro des systèmes nerveux et immunitaire de la peau. Médecine/Sciences 37:68-75 (doi: 10.1051/medsci/2020260)

Brulefert et al. (2020) Vitamin D3-elicited CD14+ human skin dendritic cells promote type-2 T helper differentiation independently of thymic stromal lymphopoietin. Allergy (doi:org/10.1111/all.14718)

Muller et al. (2018) Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells. Acta Biomater 11: 30601-9 (doi: 10.1016/j.actbio.2018.10.011)

As part of the development of new therapies, we have exploited the affinity of arboviruses for human skin immune cells to generate vectors targeting skin macrophages. This platform can be used for vaccination and immunoregulation purposes.

Publications:

Schaeffer et al. (2015) Dermal CD14+ Dendritic Cell and Macrophage Infection By Dengue Virus is Stimulated By Interleukin-4. J Invest Dermatol 135: 1743-1751 (doi: 10.1038/jid.2014.525)

Kwan et al. (2008) Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth. PLoS NeglTropDis 2: e311 (doi:10.1371/journal.pntd.0000311)