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Camara A., Lavanant A. C., Abe J., Desforges H. L., Alexandre Y. O., Girardi E., Igamberdieva Z., Asano K., Tanaka M., Hehlgans T., Pfeffer K., Pfeffer S., Mueller S. N., Stein J. V., Mueller C. G.

CD169(+) macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling Journal Article

In: Proc Natl Acad Sci U S A, vol. 119, no. 3, pp. e2108540119, 2022, ISBN: 35031565, (1091-6490 (Electronic) 0027-8424 (Linking) Journal Article).

Abstract | Links | BibTeX | Tags: PFEFFER, Team-Mueller, Unité ARN


Brulefert, Kraemer, Cumin, Selle, Hoste, Gad, Rühl, Madinier, Chaloin, Münz, Després, MUELLER, Flacher

Chikungunya virus envelope protein E2 provides a targeting vector for antigen delivery to human dermal CD14+ dendritic cells Journal Article

In: J. Invest. Dermatol, vol. 141, no. 12, pp. 2985-2989, 2021.

Links | BibTeX | Tags: Team-Mueller

Mueller, Gaiddon, Venkatasamy

Current clinical and pre-clinical imaging approaches to study the cancer-associated immune system Journal Article

In: Frontiers in Immunology, 2021.

Links | BibTeX | Tags: Team-Mueller

Muller Quentin, Berthod François, Flacher Vincent

[Tridimensional in vitro models of nervous and immune systems in the skin] Journal Article

In: Medecine Sciences: M/S, vol. 37, no. 1, pp. 68–76, 2021, ISSN: 1958-5381.

Abstract | Links | BibTeX | Tags: Team-Mueller

Madel Maria-Bernadette, Ibanez Lidia, Ciucci Thomas, Halper Julia, Topi Majlinda, Garchon Henri-Jean, Rouleau Matthieu, Mueller Christopher Georges, Biroulet Laurent Peyrin, Moulin David, Blin-Wakkach Claudine, Wakkach Abdelilah

Osteoclasts contribute to early development of chronic inflammation by promoting dysregulated hematopoiesis and myeloid skewing Journal Article

In: 2021, (working paper or preprint).

Links | BibTeX | Tags: Team-Mueller


Spenlé Caroline, Loustau Thomas, Murdamoothoo Devadarssen, Erne William, la Forest Divonne Stephanie Beghelli-de, Veber Romain, Petti Luciana, Bourdely Pierre, Mörgelin Matthias, Brauchle Eva-Maria, Cremel Gérard, Randrianarisoa Vony, Camara Abdouramane, Rekima Samah, Schaub Sebastian, Nouhen Kelly, Imhof Thomas, Hansen Uwe, Paul Nicodème, Carapito Raphael, Pythoud Nicolas, Hirschler Aurélie, Carapito Christine, Dumortier Hélène, Mueller Christopher G, Koch Manuel, Schenke-Layland Katja, Kon Shigeyuki, Sudaka Anne, Anjuère Fabienne, Obberghen-Schilling Ellen Van, Orend Gertraud

Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma Journal Article

In: Cancer Immunology Research, vol. 8, no. 9, pp. 1122–1138, 2020, ISSN: 2326-6074.

Abstract | Links | BibTeX | Tags: Dumortier, I2CT, Team-Dumortier, Team-Mueller

Jacoberger-Foissac Célia, Saliba Hanadi, Wantz May, Seguin Cendrine, Flacher Vincent, Frisch Benoît, Heurtault Béatrice, Fournel Sylvie

Liposomes as tunable platform to decipher the antitumor immune response triggered by TLR and NLR agonists Journal Article

In: European Journal of Pharmaceutics and Biopharmaceutics: Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V, vol. 152, pp. 348–357, 2020, ISSN: 1873-3441.

Abstract | Links | BibTeX | Tags: Delivery system, HPV-transformed pulmonary tumors, Liposomal nanoparticles, Team-Mueller, Therapeutic vaccines, Toll-like and nod-like receptor agonists

Mueller Christopher G, Camara Abdouramane, Flacher Vincent

[The sinusoidal microenvironment regulates the niche and the differentiation of lymph node macrophages] Journal Article

In: Medecine Sciences: M/S, vol. 36, no. 10, pp. 835–838, 2020, ISSN: 1958-5381.

Links | BibTeX | Tags: Animals, Capillaries, Cell Differentiation, Cellular, Humans, Immunity, Lymph Nodes, Lymphatic Vessels, Macrophages, Stem Cell Niche, Team-Mueller

Brulefert Adrien, Hoste Astrid, Muller Quentin, Fauny Jean-Daniel, Mueller Christopher G, Flacher Vincent

Vitamin D3-elicited CD14+ human skin dendritic cells promote thymic stromal lymphopoietin-independent type 2 T-helper responses Journal Article

In: Allergy, 2020, ISSN: 1398-9995.

Abstract | Links | BibTeX | Tags: atopic dermatitis, Dendritic cell, T helper 2, Team-Mueller, thymic stromal lymphopoietin, vitamin D3


Vargas-Franco Jorge William, Castaneda Beatriz, Gama Andrea, Mueller Christopher G, Heymann Dominique, Rédini Françoise, Lézot Frédéric

Genetically-achieved disturbances to the expression levels of TNFSF11 receptors modulate the effects of zoledronic acid on growing mouse skeletons Journal Article

In: Biochemical Pharmacology, vol. 168, pp. 133–148, 2019, ISSN: 1873-2968.

Abstract | Links | BibTeX | Tags: Animals, Bone Density Conservation Agents, Bone Development, Craniofacial bone, Gene Knockout Techniques, Growth, Inbred C57BL, Knockout, Long bone, Mice, Newborn, Osteoprotegerin, RANK ligand, RANKL/RANK/OPG, Skull, Team-Mueller, Tibia, Tooth, X-Ray Microtomography, Zoledronic acid

Mueller Christopher G, Voisin Benjamin

Of skin and bone: did Langerhans cells and osteoclasts evolve from a common ancestor? Journal Article

In: Journal of Anatomy, vol. 235, no. 2, pp. 412–417, 2019, ISSN: 1469-7580.

Abstract | Links | BibTeX | Tags: Animals, Biological Evolution, Dendritic cell, Evolution, hair follicle, Humans, Langerhans cell, Langerhans Cells, Macrophage, OSTEOCLAST, Osteoclasts, Team-Mueller

Schaeffer Evelyne, Sánchez-Fernández Elena M, Gonçalves-Pereira Rita, Flacher Vincent, Lamon Delphine, Duval Monique, Fauny Jean-Daniel, Fernández José M García, Mueller Christopher G, Mellet Carmen Ortiz

sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo Journal Article

In: European Journal of Medicinal Chemistry, vol. 169, pp. 111–120, 2019, ISSN: 1768-3254.

Abstract | Links | BibTeX | Tags: Activation, Acute Disease, Animals, antagonists & inhibitors, CD14, Cells, chemical synthesis, Chemistry, CO-RECEPTOR, Cultured, Dendritic cell, Dendritic Cells, Dose-Response Relationship, Drug, drug effects, drug therapy, Glycolipid, Glycolipids, Human, Humans, Iminosugar, immunopathology, IN VITRO, In vivo, Inbred C57BL, inflammation, Interleukin-6, lipopolysaccharide, Lipopolysaccharides, LPS, Male, Maturation, metabolism, Mice, MICROGLIA, Molecular Structure, mouse, pathology, Pharmacology, PRODUCTION, Receptor, signaling, Structure-Activity Relationship, Sulfone, Sulfoxide, Tail, target, Team-Mueller

Camara Abdouramane, Cordeiro Olga G, Alloush Farouk, Sponsel Janina, Chypre Mélanie, Onder Lucas, Asano Kenichi, Tanaka Masato, Yagita Hideo, Ludewig Burkhard, Flacher Vincent, Mueller Christopher G

Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche Journal Article

In: Immunity, vol. 50, no. 6, pp. 1467–1481.e6, 2019, ISSN: 1097-4180.

Abstract | Links | BibTeX | Tags: Activation, Animals, Biomarkers, Cell Differentiation, Cells, Cellular, Cellular Microenvironment, cytokine, Cytokines, deficiency, Differentiation, Endothelial Cells, ENDOTHELIAL-CELLS, environment, Expression, immune regulation, Immunology, Immunophenotyping, inflammation, LYMPH, LYMPH NODE, Lymph Nodes, lymphatic endothelial cells, Lymphoid Tissue, Macrophage, Macrophages, Mesenchymal Stem Cells, mesenchymal stromal cells, Mice, rank, RANK ligand, Receptor Activator of Nuclear Factor-kappa B, Regulation, Signal Transduction, Stromal Cells, Team-Mueller, transgenic


Navet Benjamin, Vargas-Franco Jorge William, Gama Andrea, Amiaud Jérome, Choi Yongwon, Yagita Hideo, Mueller Christopher G, Rédini Françoise, Heymann Dominique, Castaneda Beatriz, Lézot Frédéric

Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups Journal Article

In: Journal of Clinical Medicine, vol. 7, no. 11, 2018, ISSN: 2077-0383.

Abstract | Links | BibTeX | Tags: bone, mandible, Morphogenesis, OSTEOCLAST, RANKL, skeletal growth, Team-Mueller, Tooth

Reynard Olivier, Schaeffer Evelyne, Volchkova Valentina A, Cimarelli Andrea, Mueller Christopher G, Volchkov Viktor E

Mannoside Glycolipid Conjugates Display Antiviral Activity Against Ebola Virus Journal Article

In: The Journal of Infectious Diseases, vol. 218, no. suppl_5, pp. S666–S671, 2018, ISSN: 1537-6613.

Abstract | Links | BibTeX | Tags: Animals, Antiviral Agents, Chlorocebus aethiops, Ebolavirus, Glycolipids, Humans, Mannosides, Team-Mueller, Vero Cells, Virus Internalization

Navet Benjamin, Ando Kosei, Vargas-Franco Jorge William, Brion Régis, Amiaud Jérome, Mori Kanji, Yagita Hideo, Mueller Christopher G, Verrecchia Franck, Dumars Clotilde, Heymann Marie-Françoise, Heymann Dominique, Lézot Frédéric

The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases Journal Article

In: Cancers, vol. 10, no. 11, 2018, ISSN: 2072-6694.

Abstract | Links | BibTeX | Tags: bone, metastases, osteosarcoma, RANKL/RANK, T-Lymphocyte, Team-Mueller

Schaeffer Evelyne, Flacher Vincent, Neuberg Patrick, Hoste Astrid, Brulefert Adrien, Fauny Jean-Daniel, Wagner Alain, Mueller Christopher G

Inhibition of dengue virus infection by mannoside glycolipid conjugates Journal Article

In: Antiviral Research, vol. 154, pp. 116–123, 2018, ISSN: 1872-9096.

Abstract | Links | BibTeX | Tags: Cell Membrane, Dendritic Cells, Dengue virus, I2CT, Imagerie, inhibitors, Macrophages, Skin, Team-Mueller

Schaeffer Evelyne, Flacher Vincent, Neuberg Patrick, Hoste Astrid, Brulefert Adrien, Fauny Jean-Daniel, Wagner Alain, Mueller Christopher G

Inhibition of dengue virus infection by mannoside glycolipid conjugates Journal Article

In: Antiviral Research, vol. 154, pp. 116–123, 2018, ISSN: 1872-9096.

Abstract | Links | BibTeX | Tags: Animals, Antiviral Agents, Cell Line, Cell Membrane, Chemistry, Chlorocebus aethiops, Dendritic Cells, Dengue, Dengue virus, development, Drug, Drug Discovery, Flavivirus, function, Fusion, Glycolipids, Health, Hep G2 Cells, Human, Humans, immunopathology, infection, inhibition, inhibitors, Inhibitory Concentration 50, lipid, Macrophages, Mannosides, Membrane, Serogroup, Skin, Team-Mueller, vaccine, Vaccines, Vero Cells, viral Infection, virus, Virus Replication

Mueller C G, Nayar S, Campos J, Barone F

Molecular and Cellular Requirements for the Assembly of Tertiary Lymphoid Structures Journal Article

In: Advances in Experimental Medicine and Biology, vol. 1060, pp. 55–72, 2018, ISSN: 0065-2598.

Abstract | Links | BibTeX | Tags: Animals, CCL21, CXCL13, Endothelial and stromal cells, Humans, Lymphotoxin, Molecular Targeted Therapy, RANKL, Sjögren’s syndrome, Team-Mueller, Tertiary lymphoid structures, TNF

Mueller Christopher George, Nayar Saba, Gardner David, Barone Francesca

Cellular and Vascular Components of Tertiary Lymphoid Structures Journal Article

In: Methods in Molecular Biology (Clifton, N.J.), vol. 1845, pp. 17–30, 2018, ISSN: 1940-6029.

Abstract | Links | BibTeX | Tags: Animals, Biomarkers, CCL21, Cell Survival, Cellular Microenvironment, CXCL13, Cytokines, Humans, Immunity, inflammation, Innate, LYMPHATIC VESSEL, Lymphocyte, Lymphocyte Subsets, Lymphotoxin, Multigene Family, Neovascularization, Pathologic, Receptors, Signal Transduction, Sjögren’s syndrome, Stromal cell, Team-Mueller, Tertiary lymphoid organ, Tertiary lymphoid structures, TNF-α, Tumor Necrosis Factor

Muller Quentin, Beaudet Marie-Josée, Serres-Bérard Thiéry De, Bellenfant Sabrina, Flacher Vincent, Berthod François

Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells Journal Article

In: Acta Biomaterialia, vol. 82, pp. 93–101, 2018, ISSN: 1878-7568.

Abstract | Links | BibTeX | Tags: atopic dermatitis, Axonal migration, Biological, Canada, Cells, CGRP, Chemistry, COLLAGEN, Culture, Dermatitis, development, disease, Endothelial Cells, ENDOTHELIAL-CELLS, Epidermis, Expression, Fibroblast, Fibroblasts, function, Human, Humans, Immune System, Immunology, immunopathology, IN VITRO, Induced Pluripotent Stem Cells, inflammation, INNERVATION, Maturation, migration, Models, mouse, murine, Nerve, Neurites, Neurogenic Inflammation, Neurons, NEUROPEPTIDE, Neuropeptides, physiopathology, Pluripotent Stem Cells, Psoriasis, SCHWANN CELLS, Sensory Receptor Cells, Skin, skin disease, Skin Diseases, stem, Stem Cells, SUBSTANCE, SUBSTANCE P, Team-Mueller, Tissue Engineering, TRPV1


Chypre Mélanie, Madel Maria-Bernadette, Chaloin Olivier, Blin-Wakkach Claudine, Morice Christophe, Mueller Christopher G

Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF-κB and Its Ligand Journal Article

In: ChemMedChem, vol. 12, no. 20, pp. 1697–1702, 2017, ISSN: 1860-7187.

Abstract | Links | BibTeX | Tags: Animals, Cell Survival, cell-based assays, ELISA, Humans, Jurkat Cells, Mice, Molecular Structure, Osteoclasts, Osteogenesis, porphyrins, Protein Binding, RANK ligand, receptor activator of NF-κB, Receptor Activator of Nuclear Factor-kappa B, Structure-Activity Relationship, Team-Mueller

Onder Lucas, Mörbe Urs, Pikor Natalia, Novkovic Mario, Cheng Hung-Wei, Hehlgans Thomas, Pfeffer Klaus, Becher Burkhard, Waisman Ari, Rülicke Thomas, Gommerman Jennifer, Mueller Christopher G, Sawa Shinichiro, Scandella Elke, Ludewig Burkhard

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis Journal Article

In: Immunity, vol. 47, no. 1, pp. 80–92.e4, 2017, ISSN: 1097-4180.

Abstract | Links | BibTeX | Tags: Animals, Cell Differentiation, Cells, Choristoma, Cultured, Embryo, Endothelial Cells, fibroblastic reticular cells, Inbred C57BL, lymph node organogenesis, Lymph Nodes, lymphatic and blood endothelial cells, lymphoid stromal cells, lymphoid tissue organizer cells, Lymphotoxin beta Receptor, Lysosphingolipid, Mammalian, Mesenchymal Stem Cells, mesenchymal stromal cells, Mice, NF-kappa B, Organogenesis, Receptor Activator of Nuclear Factor-kappa B, Receptors, Signal Transduction, Team-Mueller, transgenic

Nehmar Ramzi, Alsaleh Ghada, Voisin Benjamin, Flacher Vincent, Mariotte Alexandre, Saferding Victoria, Puchner Antonia, Niederreiter Birgit, Vandamme Thierry, Schabbauer Gernot, Kastner Philippe, Chan Susan, Kirstetter Peggy, Holcmann Martin, Mueller Christopher, Sibilia Jean, Bahram Seiamak, Blüml Stephan, Georgel Philippe

Therapeutic Modulation of Plasmacytoid Dendritic Cells in Experimental Arthritis Journal Article

In: Arthritis & Rheumatology (Hoboken, N.J.), vol. 69, no. 11, pp. 2124–2135, 2017, ISSN: 2326-5205.

Abstract | Links | BibTeX | Tags: Activation, Adjuvants, Aminoquinolines, Analysis, Animal, Animals, arthritis, Assay, cancer, Cells, cytokine, Cytokines, Dendritic Cells, DEPLETION, Disease Models, drug effects, Enzyme-Linked Immunosorbent Assay, Experimental, Flow Cytometry, Gene Expression Profiling, Genetics, GLYCOPROTEIN, Glycoproteins, Human, Humans, IFN, IKAROS, Ikaros Transcription Factor, imiquimod, Immunologic, Immunology, immunopathology, inflammation, interferon, Interferon Type I, interferons, Knockout, Membrane, Membrane Glycoproteins, METHOD, methods, Mice, MODULATION, mouse, Necrosis, NECROSIS-FACTOR-ALPHA, pathogenesis, Patients, Pharmacology, physiology, plasmacytoid dendritic cells, Protein, Receptor, Reverse Transcriptase Polymerase Chain Reaction, rheumatoid, rheumatoid arthritis, Serum, signaling, Team-Mueller, TLR7, Toll-Like Receptor 7, TOPICAL APPLICATION, Transcription, TRANSCRIPTION FACTOR, transcriptome, transgenic, tumor, Tumor Necrosis Factor, Tumor Necrosis Factor-alpha

Sojod Bouchra, Chateau Danielle, Mueller Christopher G, Babajko Sylvie, Berdal Ariane, Lézot Frédéric, Castaneda Beatriz

RANK/RANKL/OPG Signalization Implication in Periodontitis: New Evidence from a RANK Transgenic Mouse Model Journal Article

In: Frontiers in Physiology, vol. 8, pp. 338, 2017, ISSN: 1664-042X.

Abstract | Links | BibTeX | Tags: alveolar bone, gingival epithelium, malassez epithelial rests (MER), Osteoclasts, periodontitis, rank, root resorption, Team-Mueller

Saliba Hanadi, Heurtault Béatrice, Bouharoun-Tayoun Hasnaa, Flacher Vincent, Frisch Benoît, Fournel Sylvie, Chamat Soulaima

Enhancing tumor specific immune responses by transcutaneous vaccination Journal Article

In: Expert Review of Vaccines, vol. 16, no. 11, pp. 1079–1094, 2017, ISSN: 1744-8395.

Abstract | Links | BibTeX | Tags: Administration, Cancer vaccine, Cancer Vaccines, Clinical Trials as Topic, Cutaneous, Dendritic Cells, Humans, liposome, Liposomes, nanoparticle, Nanoparticles, Neoplasms, Skin, skin dendritic cell, Team-Mueller, transcutaneous vaccination, Treatment Outcome, Vaccination


Chypre M, Seaman J, Cordeiro O G, Willen L, Knoop K A, Buchanan A, Sainson R C, Williams I R, Yagita H, Schneider P, Mueller C G

Characterization and application of two RANK-specific antibodies with different biological activities Journal Article

In: Immunol.Lett., vol. 171, no. 1879-0542 (Electronic), pp. 5–14, 2016.

Abstract | Links | BibTeX | Tags: Activation, Animals, ANTAGONIST, Antibodies, antibody, Antibody Affinity, Apoptosis, Assay, Cell Differentiation, Cell Surface Display Techniques, Cellular, Chemistry, comparison, Dendritic Cells, DERMAL DENDRITIC CELLS, Epithelial Cells, Epithelial microfold cell, Epitopes, Fusion, FUSION PROTEIN, HEK293 Cells, Homeostasis, Human, Humans, immune regulation, Immunization, Immunology, Immunomodulation, immunopathology, In vivo, Inbred C57BL, Intestines, Jurkat Cells, Langerhans cell, Langerhans Cells, Mice, Monoclonal, monoclonal antibody, MONOCLONAL-ANTIBODY, mouse, NF-kappa B, NF-kappaB, pathology, Protein, rank, RANK (TNFRSF11a), Receptor, Receptor Activator of Nuclear Factor-kappa B, Regulation, Secondary, Signal Transduction, signaling, Team-Mueller, therapy

Dietrich Damien, Martin Praxedis, Flacher Vincent, Sun Yu, Jarrossay David, Brembilla Nicolo, Mueller Christopher, Arnett Heather A, Palmer Gaby, Towne Jennifer, Gabay Cem

Interleukin-36 potently stimulates human M2 macrophages, Langerhans cells and keratinocytes to produce pro-inflammatory cytokines Journal Article

In: Cytokine, vol. 84, pp. 88–98, 2016, ISSN: 1096-0023.

Abstract | Links | BibTeX | Tags: agonists, ANTAGONIST, BLOOD, Cells, Cellular, Chemistry, Cultured, cytokine, CYTOKINE PRODUCTION, Cytokines, Dendritic Cells, DERMATOLOGY, Expression, Human, Humans, IL-1, IL-1R1, IL-1ra, IL-36,