Pathogenesis of bacterial infections and immunity

@article{kambris_dmmyd88_2003,

title = {DmMyD88 controls dorsoventral patterning of the Drosophila embryo},

author = {Zakaria Kambris and Hana Bilak and Rosalba D'Alessandro and Marcia Belvin and Jean-Luc Imler and Maria Capovilla},

doi = {10.1038/sj.embor.embor714},

issn = {1469-221X},

year  = {2003},

date = {2003-01-01},

journal = {EMBO reports},

volume = {4},

number = {1},

pages = {64--69},

abstract = {MyD88 is an adapter protein in the signal transduction pathway mediated by interleukin-1 (IL-1) and Toll-like receptors. A Drosophila homologue of MyD88 (DmMyD88) was recently shown to be required for the Toll-mediated immune response. In Drosophila, the Toll pathway was originally characterized for its role in the dorsoventral patterning of the embryo. We found that, like Toll, DmMyD88 messenger RNA is maternally supplied to the embryo. Here we report the identification of a new mutant allele of DmMyD88, which generates a protein lacking the carboxy-terminal extension, normally located downstream of the Toll/IL-1 receptor domain. Homozygous mutant female flies lay dorsalized embryos that are rescued by expression of a transgenic DmMyD88 complementary DNA. The DmMyD88 mutation blocks the ventralizing activity of a gain-of-function Toll mutation. These results show that DmMyD88 encodes an essential component of the Toll pathway in dorsoventral pattern formation.},

keywords = {Adaptor Proteins, Alleles, Animals, Antigens, Base Sequence, Cell Surface, Complementary, Developmental, Differentiation, DNA, DNA Transposable Elements, Egg Proteins, Embryo, Exons, Female, Gene Expression Regulation, Genetically Modified, Genotype, imler, Immunity, Immunologic, Innate, Insertional, M3i, Male, messenger, Morphogenesis, Mutagenesis, Myeloid Differentiation Factor 88, Nonmammalian, Oocytes, Protein Biosynthesis, Protein Structure, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transducing, Tertiary, Toll-Like Receptors, Zygote},

pubstate = {published},

tppubtype = {article}

}

@article{ferrandon_staufen_1994b,

title = {Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner},

author = {Dominique Ferrandon and L Elphick and C Nüsslein-Volhard and St D Johnston},

issn = {0092-8674},

year  = {1994},

date = {1994-12-01},

journal = {Cell},

volume = {79},

number = {7},

pages = {1221--1232},

abstract = {Staufen protein is required in order to anchor bicoid (bcd) mRNA at the anterior pole of the Drosophila egg. Here we show that staufen protein colocalizes with bcd mRNA at the anterior, and that this localization depends upon its association with the mRNA. Upon injection into the embryo, bcd transcripts specifically interact with staufen, and we have mapped the sequences required to three regions of the 3'UTR, each of which is predicted to form a long stem-loop. The resulting staufen-bcd 3'UTR complexes form particles that show a microtubule-dependent localization. Since staufen is also transported with oskar (osk) mRNA during oogenesis, staufen associates specifically with both osk and bcd mRNAs to mediate their localizations, but at two distinct stages of development.},

keywords = {Animals, Base Sequence, Cell Polarity, ferrandon, Homeodomain Proteins, Insect Hormones, M3i, messenger, Microtubules, Nucleic Acid Conformation, Oocytes, RNA, RNA-Binding Proteins, Trans-Activators},

pubstate = {published},

tppubtype = {article}

}

@article{lanot_further_1988,

title = {Further experimental evidence for the involvement of ecdysone in the control of meiotic reinitiation in oocytes of Locusta migratoria (Insecta, Orthoptera)},

author = {R Lanot and J Thiebold and M F Costet-Corio and P Benveniste and Jules A Hoffmann},

issn = {0012-1606},

year  = {1988},

date = {1988-03-01},

journal = {Dev. Biol.},

volume = {126},

number = {1},

pages = {212--214},

abstract = {Ecdysone has recently been shown to be able to trigger meiotic reinitiation in vitro in submature oocytes of Locusta. In the present study we have experimentally depressed (by 60-70%) ecdysone biosynthesis in the ovaries of adult females by rearing them on a diet with a modified sterol profile. Mature oocytes from such females fail to undergo normal reinitiation, but when incubated in vitro, can be induced to break their meiotic arrest by the addition of exogenous ecdysone. These results lend further support to the hypothesis that in Locusta, ovarian ecdysone is involved in the control of meiotic reinitiation.},

keywords = {Animals, Ecdysone, Female, Grasshoppers, hoffmann, M3i, Meiosis, Oocytes, Ovary},

pubstate = {published},

tppubtype = {article}

}

@article{goltzene_follicle_1978,

title = {The follicle cell epithelium of maturing ovaries of Locusta migratoria: a new biosynthetic tissue for ecdysone},

author = {F Goltzené and Marie Lagueux and Maurice Charlet and Jules A Hoffmann},

issn = {0018-4888},

year  = {1978},

date = {1978-10-01},

journal = {Hoppe-Seyler's Z. Physiol. Chem.},

volume = {359},

number = {10},

pages = {1427--1434},

abstract = {Follicle cells of maturing ovaries of Locusta migratoria are demonstrated to synthesize the moulting hormone ecdysone (2beta,3beta,14alpha,22R,25-pentahydroxy-5beta-cholest-7-en-6-one). Studies of secretory kinetics under in vitro conditions show that the intensity of hormone secretion is strictly dependent on the stage of maturation of the excised ovaries.},

keywords = {Animals, Ecdysone, Epithelium, Female, Grasshoppers, hoffmann, Kinetics, M3i, Oocytes, Ovarian Follicle, Ovary, Sexual Maturation},

pubstate = {published},

tppubtype = {article}

}