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2014

Imler Jean-Luc

Overview of Drosophila immunity: a historical perspective Journal Article

In: Developmental and Comparative Immunology, vol. 42, no. 1, pp. 3–15, 2014, ISSN: 1879-0089.

Abstract | Links | BibTeX | Tags: Allergy and Immunology, Animal, Animals, Antimicrobial Cationic Peptides, Antimicrobial peptides, history, Humans, IMD pathway, imler, Immunity, Innate, innate immunity, M3i, Models, Pattern recognition receptors, Signal Transduction, Toll-Like Receptors

2013

Quintin Jessica, Asmar Joelle, Matskevich Alexey A, Lafarge Marie-Céline, Ferrandon Dominique

The Drosophila Toll pathway controls but does not clear Candida glabrata infections Journal Article

In: J. Immunol., vol. 190, no. 6, pp. 2818–2827, 2013, ISSN: 1550-6606.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Animal, Animals, Antigens, Candida glabrata, Candidiasis, Cells, Cultured, Differentiation, Disease Models, ferrandon, Immunologic, M3i, Phagocytosis, Receptors, Signal Transducing, Signal Transduction, Toll-Like Receptors, Virulence

Ayyaz Arshad, Giammarinaro Philippe, Liégeois Samuel, Lestradet Matthieu, Ferrandon Dominique

A negative role for MyD88 in the resistance to starvation as revealed in an intestinal infection of Drosophila melanogaster with the Gram-positive bacterium Staphylococcus xylosus Journal Article

In: Immunobiology, vol. 218, no. 4, pp. 635–644, 2013, ISSN: 1878-3279.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Animal, Animals, Antigens, Differentiation, Disease Models, ferrandon, Immunity, Immunologic, Innate, Intestinal Diseases, M3i, Mucosal, Mutation, Receptors, Signal Transducing, Staphylococcal Infections, Staphylococcus, Starvation, Toll-Like Receptors

2012

Lemaitre Bruno, Nicolas Emmanuelle, Michaut Lydia, Reichhart Jean-Marc, Hoffmann Jules A

Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983 Journal Article

In: J. Immunol., vol. 188, no. 11, pp. 5210–5220, 2012, ISSN: 1550-6606.

Abstract | BibTeX | Tags: Animals, Antifungal Agents, Developmental, DNA-Binding Proteins, Gene Expression Regulation, history, hoffmann, M3i, Multigene Family, Mycoses, Phosphoproteins, reichhart, Toll-Like Receptors

2011

Chtarbanova Stanislava, Imler Jean-Luc

Microbial sensing by Toll receptors: a historical perspective Journal Article

In: Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 8, pp. 1734–1738, 2011, ISSN: 1524-4636.

Abstract | Links | BibTeX | Tags: Animals, Cardiovascular Diseases, history, Host-Pathogen Interactions, Humans, imler, Immunity, Innate, M3i, Macrophages, Toll-Like Receptors

Kellenberger Christine, Leone Philippe, Coquet Laurent, Jouenne Thierry, Reichhart Jean-Marc, Roussel Alain

Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation Journal Article

In: J. Biol. Chem., vol. 286, no. 14, pp. 12300–12307, 2011, ISSN: 1083-351X.

Abstract | Links | BibTeX | Tags: Animals, Catalytic Domain, Cell Line, M3i, reichhart, Serine Proteases, Signal Transduction, Structure-Activity Relationship, Toll-Like Receptors

2010

Matskevich Alexey A, Quintin Jessica, Ferrandon Dominique

The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function Journal Article

In: Eur. J. Immunol., vol. 40, no. 5, pp. 1244–1254, 2010, ISSN: 1521-4141.

Abstract | Links | BibTeX | Tags: Agglutination, Animals, Beauveria, Beauveria/immunology, Candida albicans, Candida albicans/immunology, Carrier Proteins, Carrier Proteins/*immunology/pharmacology, Drosophila melanogaster/*immunology/microbiology, Drosophila Proteins/*immunology/pharmacology/physiology, Enzyme Activation, ferrandon, Fungal, Fungi, Fungi/*immunology, Hemolymph, Hemolymph/immunology, M3i, Melanins, Melanins/*physiology, Monophenol Monooxygenase, Monophenol Monooxygenase/physiology, Multiprotein Complexes, Multiprotein Complexes/physiology, Recombinant Fusion Proteins, Recombinant Fusion Proteins/pharmacology, Serpins, Serpins/physiology, Spores, Toll-Like Receptors, Toll-Like Receptors/immunology

2009

Shia Alice K H, Glittenberg Marcus, Thompson Gavin, Weber Alexander N R, Reichhart Jean-Marc, Ligoxygakis Petros

Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes Journal Article

In: J. Cell. Sci., vol. 122, no. Pt 24, pp. 4505–4515, 2009, ISSN: 1477-9137.

Abstract | Links | BibTeX | Tags: Animals, Enterococcus faecalis, Escherichia coli, Fat Body, Hemocytes, Larva, M3i, reichhart, Toll-Like Receptors

2008

Chamy L El, Leclerc V, Caldelari I, Reichhart J-M

Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll Journal Article

In: Nat. Immunol., vol. 9, no. 10, pp. 1165–1170, 2008, ISSN: 1529-2916.

Abstract | Links | BibTeX | Tags: Animals, Fungi, Genetically Modified, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, In Situ Hybridization, M3i, Mycoses, Pattern Recognition, Peptide Hydrolases, Receptors, reichhart, ROMBY, Serine Endopeptidases, Signal Transduction, Toll-Like Receptors, Unité ARN

Goto Akira, Matsushita Kazufumi, Gesellchen Viola, Chamy Laure El, Kuttenkeuler David, Takeuchi Osamu, Hoffmann Jules A, Akira Shizuo, Boutros Michael, Reichhart Jean-Marc

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice Journal Article

In: Nat. Immunol., vol. 9, no. 1, pp. 97–104, 2008, ISSN: 1529-2916.

Abstract | Links | BibTeX | Tags: Animals, Cell Line, Embryo, Fibroblasts, hoffmann, Humans, Immunity, Innate, Interleukin-1beta, M3i, Mammalian, Mice, NF-kappa B, Nuclear Proteins, Proteins, reichhart, Signal Transduction, Toll-Like Receptors, transgenic, Tumor Necrosis Factor-alpha

2007

Weber Alexander N R, Gangloff Monique, Moncrieffe Martin C, Hyvert Yann, Imler Jean-Luc, Gay Nicholas J

Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand Journal Article

In: The Journal of Biological Chemistry, vol. 282, no. 18, pp. 13522–13531, 2007, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Animals, Cytokines, dimerization, imler, ligands, M3i, Post-Translational, Protein Binding, Protein Processing, Protein Structure, Signal Transduction, Tertiary, Toll-Like Receptors

2006

Flacher Vincent, Bouschbacher Marielle, Verronèse Estelle, Massacrier Catherine, Sisirak Vanja, Berthier-Vergnes Odile, de Saint-Vis Blandine, Caux Christophe, Dezutter-Dambuyant Colette, Lebecque Serge, Valladeau Jenny

Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria Journal Article

In: Journal of Immunology (Baltimore, Md.: 1950), vol. 177, no. 11, pp. 7959–7967, 2006, ISSN: 0022-1767.

Abstract | Links | BibTeX | Tags: bacteria, Double-Stranded, Gram-Positive Bacteria, Human, Humans, Interleukin-6, Interleukin-8, Langerhans Cells, Reverse Transcriptase Polymerase Chain Reaction, RNA, Skin, Team-Mueller, TLR4, TLR7, Toll-Like Receptors, Tumor Necrosis Factor-alpha, viruses

Evans J D, Aronstein K, Chen Y P, Hetru Charles, Imler Jean-Luc, Jiang H, Kanost M, Thompson G J, Zou Z, Hultmark D

Immune pathways and defence mechanisms in honey bees Apis mellifera Journal Article

In: Insect Molecular Biology, vol. 15, no. 5, pp. 645–656, 2006, ISSN: 0962-1075.

Abstract | Links | BibTeX | Tags: Animals, Bees, Carrier Proteins, Genome, imler, Immunity, Insect, Janus Kinases, M3i, Multigene Family, Serine Endopeptidases, Signal Transduction, STAT Transcription Factors, Toll-Like Receptors

Chen Li-Ying, Wang Juinn-Chin, Hyvert Yann, Lin Hui-Ping, Perrimon Norbert, Imler Jean-Luc, Hsu Jui-Chou

Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo Journal Article

In: Current biology: CB, vol. 16, no. 12, pp. 1183–1193, 2006, ISSN: 0960-9822.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Animals, Antigens, Biological, Body Patterning, Cell Membrane, Differentiation, dimerization, DNA-Binding Proteins, Embryo, Epistasis, Genetic, imler, Immunity, Immunologic, Innate, M3i, Models, Mutation, Nonmammalian, Phenotype, Phosphoproteins, Receptors, Signal Transducing, Toll-Like Receptors, Transcription Factors, Zinc Fingers

Galiana-Arnoux Delphine, Imler Jean-Luc

Toll-like receptors and innate antiviral immunity Journal Article

In: Tissue Antigens, vol. 67, no. 4, pp. 267–276, 2006, ISSN: 0001-2815.

Abstract | Links | BibTeX | Tags: Animals, Humans, imler, Immunity, Innate, M3i, Signal Transduction, Toll-Like Receptors, Virus Diseases

2005

Martinelli Cosimo, Reichhart Jean-Marc

Evolution and integration of innate immune systems from fruit flies to man: lessons and questions Journal Article

In: J. Endotoxin Res., vol. 11, no. 4, pp. 243–248, 2005, ISSN: 0968-0519.

Abstract | Links | BibTeX | Tags: Animals, Biological Evolution, Cell Surface, Forecasting, Humans, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Weber Alexander N R, Moncrieffe Martin C, Gangloff Monique, Imler Jean-Luc, Gay Nicholas J

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway Journal Article

In: The Journal of Biological Chemistry, vol. 280, no. 24, pp. 22793–22799, 2005, ISSN: 0021-9258.

Abstract | Links | BibTeX | Tags: Amino Acid, Animals, Biophysical Phenomena, Biophysics, Body Patterning, Calorimetry, Cell Line, Cell Surface, Cross-Linking Reagents, Cytokines, dimerization, Electrophoresis, Humans, imler, ligands, Luciferases, M3i, Membrane Glycoproteins, Polyacrylamide Gel, Protein Binding, Protein Structure, Receptors, Recombinant Proteins, Sequence Homology, Signal Transduction, Tertiary, Time Factors, Toll-Like Receptors, Ultracentrifugation

2004

Bischoff Vincent, Vignal Cécile, Boneca Ivo G, Michel Tatiana, Hoffmann Jules A, Royet Julien

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria Journal Article

In: Nat. Immunol., vol. 5, no. 11, pp. 1175–1180, 2004, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Animals, Carrier Proteins, Cell Surface, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, hoffmann, M3i, Mutation, Mycoses, Receptors, Staphylococcus aureus, Toll-Like Receptors

Leclerc Vincent, Reichhart Jean-Marc

The immune response of Drosophila melanogaster Journal Article

In: Immunol. Rev., vol. 198, pp. 59–71, 2004, ISSN: 0105-2896.

Abstract | BibTeX | Tags: Animals, Cell Surface, Immunity, Immunological, Innate, M3i, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

Imler Jean-Luc, Zheng Liangbiao

Biology of Toll receptors: lessons from insects and mammals Journal Article

In: Journal of Leukocyte Biology, vol. 75, no. 1, pp. 18–26, 2004, ISSN: 0741-5400.

Abstract | Links | BibTeX | Tags: Animals, Anopheles, Cell Surface, Humans, imler, M3i, Membrane Glycoproteins, Mice, Phylogeny, Plant Physiological Phenomena, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Imler Jean-Luc, Ferrandon Dominique, Royet Julien, Reichhart Jean-Marc, Hetru Charles, Hoffmann Jules A

Toll-dependent and Toll-independent immune responses in Drosophila Journal Article

In: Journal of Endotoxin Research, vol. 10, no. 4, pp. 241–246, 2004, ISSN: 0968-0519.

Abstract | Links | BibTeX | Tags: Acute-Phase Proteins, Animals, Blood Proteins, Cell Surface, ferrandon, hoffmann, imler, Insect Proteins, M3i, Membrane Glycoproteins, Receptors, reichhart, Toll-Like Receptor 5, Toll-Like Receptors, Up-Regulation

2003

Ligoxygakis Petros, Roth Siegfried, Reichhart Jean-Marc

A serpin regulates dorsal-ventral axis formation in the Drosophila embryo Journal Article

In: Curr. Biol., vol. 13, no. 23, pp. 2097–2102, 2003, ISSN: 0960-9822.

Abstract | BibTeX | Tags: Animals, Body Patterning, Cell Surface, Crosses, Female, Genetic, Immunohistochemistry, M3i, Microinjections, Receptors, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors

Reichhart Jean-Marc

TLR5 takes aim at bacterial propeller Journal Article

In: Nat. Immunol., vol. 4, no. 12, pp. 1159–1160, 2003, ISSN: 1529-2908.

Links | BibTeX | Tags: Animals, Bacterial Physiological Phenomena, Cell Surface, Flagella, Flagellin, Humans, M3i, Membrane Glycoproteins, Receptors, reichhart, Toll-Like Receptor 5, Toll-Like Receptors

Gobert Vanessa, Gottar Marie, Matskevich Alexey A, Rutschmann Sophie, Royet Julien, Belvin Marcia, Hoffmann Jules A, Ferrandon Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Journal Article

In: Science, vol. 302, no. 5653, pp. 2126–2130, 2003, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Animals, Carrier Proteins, Cell Surface, DNA Transposable Elements, ferrandon, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, hoffmann, Hypocreales, Insect, Insect Proteins, M3i, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

Goto Akira, Blandin Stéphanie A, Royet Julien, Reichhart Jean-Marc, Levashina Elena A

Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies Journal Article

In: Nucleic Acids Res., vol. 31, no. 22, pp. 6619–6623, 2003, ISSN: 1362-4962.

Abstract | BibTeX | Tags: Animals, blandin, Cell Surface, Double-Stranded, Epistasis, Female, Genetic, Green Fluorescent Proteins, Homeodomain Proteins, Luminescent Proteins, M3i, Phenotype, Receptors, reichhart, RNA, RNA Interference, Serpins, Signal Transduction, Time Factors, Toll-Like Receptors, Transcription Factors

Hoffmann Jules A

The immune response of Drosophila Journal Article

In: Nature, vol. 426, no. 6962, pp. 33–38, 2003, ISSN: 1476-4687.

Abstract | Links | BibTeX | Tags: Animals, Cell Surface, hoffmann, Immunity, Innate, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Weber Alexander N R, Tauszig-Delamasure Servane, Hoffmann Jules A, Lelièvre Eric, Gascan Hugues, Ray Keith P, Morse Mary A, Imler Jean-Luc, Gay Nicholas J

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Journal Article

In: Nature Immunology, vol. 4, no. 8, pp. 794–800, 2003, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Animals, Cell Surface, hoffmann, imler, Insect Proteins, M3i, Protein Binding, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

Bilak Hana, Tauszig-Delamasure S, Imler Jean-Luc

Toll and Toll-like receptors in Drosophila Journal Article

In: Biochemical Society Transactions, vol. 31, no. Pt 3, pp. 648–651, 2003, ISSN: 0300-5127.

Abstract | Links | BibTeX | Tags: Animals, Biological Evolution, Cell Surface, Fungi, Genome, Gram-Negative Bacteria, Gram-Positive Bacteria, imler, M3i, Membrane Glycoproteins, Receptors, Toll-Like Receptor 5, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Toll signaling: the TIReless quest for specificity Journal Article

In: Nature Immunology, vol. 4, no. 2, pp. 105–106, 2003, ISSN: 1529-2908.

Links | BibTeX | Tags: Animals, Cell Surface, Dendritic Cells, hoffmann, Humans, imler, Immunological, Interferon-beta, M3i, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

Kambris Zakaria, Bilak Hana, D'Alessandro Rosalba, Belvin Marcia, Imler Jean-Luc, Capovilla Maria

DmMyD88 controls dorsoventral patterning of the Drosophila embryo Journal Article

In: EMBO reports, vol. 4, no. 1, pp. 64–69, 2003, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Alleles, Animals, Antigens, Base Sequence, Cell Surface, Complementary, Developmental, Differentiation, DNA, DNA Transposable Elements, Egg Proteins, Embryo, Exons, Female, Gene Expression Regulation, Genetically Modified, Genotype, imler, Immunity, Immunologic, Innate, Insertional, M3i, Male, messenger, Morphogenesis, Mutagenesis, Myeloid Differentiation Factor 88, Nonmammalian, Oocytes, Protein Biosynthesis, Protein Structure, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Signal Transducing, Tertiary, Toll-Like Receptors, Zygote

2002

Ligoxygakis Petros, Pelte Nadège, Ji Chuanyi, Leclerc Vincent, Duvic Bernard, Belvin Marcia, Jiang Haobo, Hoffmann Jules A, Reichhart Jean-Marc

A serpin mutant links Toll activation to melanization in the host defence of Drosophila Journal Article

In: EMBO J., vol. 21, no. 23, pp. 6330–6337, 2002, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Animals, Cell Surface, Hemolymph, hoffmann, infection, M3i, Melanins, Receptors, reichhart, Serpins, Toll-Like Receptors

Kambris Zakaria, Hoffmann Jules A, Imler Jean-Luc, Capovilla Maria

Tissue and stage-specific expression of the Tolls in Drosophila embryos Journal Article

In: Gene expression patterns: GEP, vol. 2, no. 3-4, pp. 311–317, 2002, ISSN: 1567-133X.

Abstract | BibTeX | Tags: Animals, Blotting, Cell Surface, Gene Expression Profiling, hoffmann, imler, Larva, M3i, Multigene Family, Northern, Receptors, Toll-Like Receptors

Ligoxygakis Petros, Pelte Nadège, Hoffmann Jules A, Reichhart Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Journal Article

In: Science, vol. 297, no. 5578, pp. 114–116, 2002, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Animals, Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, hoffmann, Hypocreales, Insect, Insect Proteins, M3i, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, reichhart, Serine Endopeptidases, Tertiary, Toll-Like Receptors

Hoffmann Jules A, Reichhart Jean-Marc

Drosophila innate immunity: an evolutionary perspective Journal Article

In: Nat. Immunol., vol. 3, no. 2, pp. 121–126, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Animals, Biological Evolution, Cell Surface, hoffmann, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

Tauszig-Delamasure Servane, Bilak Hana, Capovilla Maria, Hoffmann Jules A, Imler Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

In: Nature Immunology, vol. 3, no. 1, pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Animals, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, hoffmann, Hypocreales, imler, Immunologic, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

Imler Jean-Luc, Hoffmann Jules A

Toll receptors in Drosophila: a family of molecules regulating development and immunity Journal Article

In: Current Topics in Microbiology and Immunology, vol. 270, pp. 63–79, 2002, ISSN: 0070-217X.

Abstract | BibTeX | Tags: Animals, Cell Surface, Genetic, Gram-Negative Bacteria, hoffmann, imler, M3i, Receptors, Signal Transduction, Toll-Like Receptors, Transcription

2001

Michel T, Reichhart Jean-Marc, Hoffmann Jules A, Royet Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Journal Article

In: Nature, vol. 414, no. 6865, pp. 756–759, 2001, ISSN: 0028-0836.

Abstract | Links | BibTeX | Tags: Amino Acid, Animals, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, hoffmann, Humans, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, reichhart, Sequence Homology, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Toll receptors in innate immunity Journal Article

In: Trends in Cell Biology, vol. 11, no. 7, pp. 304–311, 2001, ISSN: 0962-8924.

Abstract | BibTeX | Tags: Animals, Cell Surface, hoffmann, Humans, imler, Immunity, Immunologic, Innate, M3i, Membrane Glycoproteins, Membrane Proteins, Receptors, Toll-Like Receptors

2000

Lagueux Marie, Perrodou E, Levashina Elena A, Capovilla Maria, Hoffmann Jules A

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 97, no. 21, pp. 11427–11432, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: alpha-Macroglobulins, Amino Acid, Animals, Cell Surface, Complement C3, Esters, Genetic, hoffmann, Insect Proteins, Janus Kinases, M3i, Membrane Glycoproteins, Mutation, Protein-Tyrosine Kinases, Proteins, Receptors, Sequence Homology, Sulfhydryl Compounds, Toll-Like Receptors, Transcription, Transcription Factors

Rutschmann Sophie, Jung Alain C, Zhou R, Silverman N, Hoffmann Jules A, Ferrandon Dominique

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response Journal Article

In: Nat. Immunol., vol. 1, no. 4, pp. 342–347, 2000, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Animals, Antigens, Bacterial, Cell Surface, ferrandon, Gene Expression Regulation, hoffmann, I-kappa B Kinase, Immunity, Innate, Insect Proteins, M3i, Membrane Glycoproteins, Protein-Serine-Threonine Kinases, Receptors, Signal Transduction, Toll-Like Receptors, Transcription Factors

Tauszig Servane, Jouanguy Emmanuelle, Hoffmann Jules A, Imler Jean-Luc

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 19, pp. 10520–10525, 2000, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: Amino Acid, Animals, Anti-Bacterial Agents, Blotting, Cell Line, Cell Surface, hoffmann, imler, M3i, Membrane Glycoproteins, Multigene Family, Northern, Peptides, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Signaling mechanisms in the antimicrobial host defense of Drosophila Journal Article

In: Current Opinion in Microbiology, vol. 3, no. 1, pp. 16–22, 2000, ISSN: 1369-5274.

Abstract | BibTeX | Tags: Animals, Anti-Infective Agents, Cell Surface, Gene Expression Regulation, Genes, hoffmann, imler, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptors

Imler Jean-Luc, Tauszig Servane, Jouanguy Emmanuelle, Forestier C, Hoffmann Jules A

LPS-induced immune response in Drosophila Journal Article

In: Journal of Endotoxin Research, vol. 6, no. 6, pp. 459–462, 2000, ISSN: 0968-0519.

Abstract | BibTeX | Tags: Animals, Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, hoffmann, imler, Insect, Insect Proteins, Lipopolysaccharides, M3i, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Toll and Toll-like proteins: an ancient family of receptors signaling infection Journal Article

In: Reviews in Immunogenetics, vol. 2, no. 3, pp. 294–304, 2000, ISSN: 1398-1714.

Abstract | BibTeX | Tags: Adaptor Proteins, Animals, Antigens, Autoantigens, CD14, Cell Adhesion Molecules, Cell Surface, Differentiation, DNA-Binding Proteins, Gene Expression Regulation, hoffmann, I-kappa B Proteins, imler, Immunity, Immunologic, infection, Innate, Insect Proteins, Interleukin-1 Receptor-Associated Kinases, Knockout, Larva, Lipopolysaccharides, M3i, Mammals, MAP Kinase Signaling System, Membrane Glycoproteins, Membrane Proteins, Mice, Multigene Family, Myeloid Differentiation Factor 88, NF-kappa B, peptidoglycan, Phosphorylation, Post-Translational, Protein Kinases, Protein Processing, Protein Structure, Receptors, Recombinant Fusion Proteins, Signal Transducing, Signal Transduction, Teichoic Acids, Tertiary, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptor 6, Toll-Like Receptor 9, Toll-Like Receptors, Ubiquitins

1999

Levashina Elena A, Langley E, Green C, Gubb David, Ashburner M, Hoffmann Jules A, Reichhart Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Journal Article

In: Science, vol. 285, no. 5435, pp. 1917–1919, 1999, ISSN: 0036-8075.

Abstract | BibTeX | Tags: Animals, Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, hoffmann, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

Manfruelli P, Reichhart Jean-Marc, Steward R, Hoffmann Jules A, Lemaitre Bruno

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF Journal Article

In: EMBO J., vol. 18, no. 12, pp. 3380–3391, 1999, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Animals, Anti-Infective Agents, Cell Surface, Clone Cells, DNA-Binding Proteins, Fat Body, Female, Gene Expression Regulation, Genes, hoffmann, Insect, Insect Proteins, Larva, M3i, Male, Membrane Glycoproteins, Mosaicism, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, reichhart, Reporter, Signal Transduction, Toll-Like Receptors, Transcription Factors

1998

Ferrandon Dominique, Jung Alain C, Criqui M, Lemaitre Bruno, Uttenweiler-Joseph S, Michaut Lydia, Reichhart Jean-Marc, Hoffmann Jules A

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway Journal Article

In: EMBO J., vol. 17, no. 5, pp. 1217–1227, 1998, ISSN: 0261-4189.

Abstract | Links | BibTeX | Tags: Animals, bacteria, Cell Surface, Developmental, Digestive System, Epithelium, Fat Body, Female, ferrandon, Fungal, Gene Expression Regulation, Genes, Green Fluorescent Proteins, hoffmann, Insect Proteins, Larva, Luminescent Proteins, M3i, Male, Membrane Glycoproteins, Organ Specificity, Receptors, reichhart, Reporter, Respiratory System, Spores, Toll-Like Receptors, Trachea, Transgenes

Nicolas E, Reichhart Jean-Marc, Hoffmann Jules A, Lemaitre Bruno

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila Journal Article

In: J. Biol. Chem., vol. 273, no. 17, pp. 10463–10469, 1998, ISSN: 0021-9258.

Abstract | BibTeX | Tags: Animals, Cell Surface, DNA-Binding Proteins, Gene Expression Regulation, hoffmann, Insect Proteins, Larva, M3i, Membrane Glycoproteins, Phosphoproteins, Proto-Oncogene Proteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors, Transcription Factor RelB, Transcription Factors

1996

Lemaitre Bruno, Nicolas E, Michaut Lydia, Reichhart Jean-Marc, Hoffmann Jules A

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Journal Article

In: Cell, vol. 86, no. 6, pp. 973–983, 1996, ISSN: 0092-8674.

Abstract | BibTeX | Tags: Animals, Antifungal Agents, Cell Surface, DNA-Binding Proteins, Fungi, Gene Expression, Genes, hoffmann, Insect, Insect Hormones, Insect Proteins, M3i, Membrane Glycoproteins, MHC Class II, Mutation, Mycoses, NF-kappa B, Phosphoproteins, Proteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

1995

Lemaitre Bruno, Meister Marie, Govind S, Georgel Philippe, Steward R, Reichhart Jean-Marc, Hoffmann Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Journal Article

In: EMBO J., vol. 14, no. 3, pp. 536–545, 1995, ISSN: 0261-4189.

Abstract | BibTeX | Tags: Animals, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, hoffmann, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, M3i, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors