Direct access Research units



Thomès L, Lescure A

Mosaic evolution of the phosphopantothenate biosynthesis pathway in bacteria and archaea Journal Article

In: Genome Biology and Evolution, vol. 13, no. 2, pp. evaa262, 2020.

Abstract | Links | BibTeX | Tags: Candidatus poribacteria, Coenzyme A, LESCURE, phosphopantothenate pathway, Unité ARN

Despons L, Martin F

How Many Messenger RNAs Can Be Translated by the START Mechanism? Journal Article

In: International Journal of Molecular Sciences, vol. 21, no. 21, pp. 8373, 2020.

Abstract | Links | BibTeX | Tags: ERIANI, LESCURE, mRNA, Ribosome, secondary structures, START, translation initiation, Unité ARN

Chernorudskiy A, Varone E, Colombo S F, Fumagalli S, Cagnotto A, Cattaneo A, Briens M, Baltzinger M, Kuhn L, Bachi A, Berardi A, Salmona M, Musco G, Borgese N, Lescure A, Zito E

Selenoprotein N is an endoplasmic reticulum calcium sensor that links luminal calcium levels to a redox activity Journal Article

In: Proc Natl Acad Sci U S A, vol. 117, no. 35, pp. 21288-21298, 2020, ISBN: 32817544.

Abstract | Links | BibTeX | Tags: LESCURE, PPSE, Unité ARN


Janvier A, Despons L, Schaeffer L, Tidu A, Martin F, Eriani G

A tRNA-mimic Strategy to Explore the Role of G34 of tRNAGly in Translation and Codon Frameshifting Journal Article

In: Int J Mol Sci, vol. 20, no. 16, pp. 3911, 2019, ISBN: 31405256.

Abstract | Links | BibTeX | Tags: ERIANI, IRES element frameshifting genetic code glycine codon tRNA translation, LESCURE, Unité ARN


Paulson R F, Nettleford S, Liao C, Chen Y, Hao S, Baltzinger M, Thami-Braye M, Lescure A, Prabhu K S

The role of Selenoprotein N in the differentiation of erythroid progenitors during stress erythropoiesis Miscellaneous


Abstract | BibTeX | Tags: LESCURE, Unité ARN

Lescure A, Baltzinger M, Zito E

Uncovering the Importance of Selenium in Muscle Disease Book Chapter

In: Michalke, B (Ed.): Selenium: Series Molecular and Integrative Toxicology, pp. 345-362, Springer, New-York, 2018.

Abstract | Links | BibTeX | Tags: elenium Selenoproteins Muscle disease Oxidative stress Calcium transport RYR SERCA, LESCURE, Unité ARN

Smyth R. P., Smith M. R., Jousset A. C., Despons L., Laumond G., Decoville T., Cattenoz P., Moog C., Jossinet F., Mougel M., Paillart J. C., Kleist M., Marquet R.

In cell mutational interference mapping experiment (in cell MIME) identifies the 5' polyadenylation signal as a dual regulator of HIV-1 genomic RNA production and packaging Journal Article

In: Nucleic Acids Res, vol. 46, no. 9, pp. e57, 2018, ISBN: 29514260, (1362-4962 (Electronic) 0305-1048 (Linking) Journal Article Research Support, Non-U.S. Gov't).

Abstract | Links | BibTeX | Tags: 5' Untranslated Regions Genome, LESCURE, Ribonucleic Acid *Virus Assembly Virus Replication, Unité ARN, Viral HEK293 Cells HIV-1/*genetics/physiology Humans Mutation Nucleotide Motifs Poly A/metabolism RNA, Viral/*biosynthesis/*chemistry *Regulatory Sequences


Lescure A, Briens M, Ferreiro A

What do we know about selenium contribution to muscle physiology? Book Chapter

In: Hatfield, D L; Schweizer, U; Tsuji, P A; Gladyshev, V (Ed.): Selenium: Its molecular biology and role in human health, pp. 475-486, Springer, 4, 2016.

Abstract | Links | BibTeX | Tags: Intracellular calcium handling Muscle Muscular dystrophies Oxidative stress Selenium Selenoprotein N, LESCURE, Unité ARN

Gladyshev V N, Arnér E S, Berry M J, Brigelius-Flohé R, Bruford E A, Burk R F, Carlson B A, Castellano S, Chavatte L, Conrad M, Copeland P R, Diamond A M, Driscoll D M, Ferreiro A, Flohé L, Green F R, Guigó R, Handy D E, Hatfield D L, Hesketh J, Hoffmann P R, Holmgren A, Hondal R J, Howard M T, Huang K, Kim H Y, Kim I Y, Köhrle J, Krol A, Kryukov G V, Lee B J, Lee B C, Lei X G, Liu Q, Lescure A, Lobanov A V, Loscalzo J, Maiorino M, Mariotti M, Prabhu K S, Rayman M P, Rozovsky S, Salinas G, Schomburg L, Schweizer U, Simonović M, Sunde R A, Tsuji P A, Tweedie S, Ursini F, Zhang Y

Selenoprotein Gene Nomenclature. Journal Article

In: J Biol Chem, vol. 291, no. 46, pp. 24036-24040, 2016, ISBN: 27645994.

Abstract | Links | BibTeX | Tags: function gene name genomics nomenclature selenium selenocysteine selenoprotein structure-function, LESCURE, Unité ARN

Guedich S, Puffer-Enders B, Baltzinger M, Hoffmann G, Veiga C Da, Jossinet F, Thore S, Bec G, Ennifar E, Burnouf D, Dumas P

Quantitative and predictive model of kinetic regulation by E. coli TPP riboswitches. Journal Article

In: RNA Biol, vol. 13, no. 4, pp. 373-390, 2016, ISBN: 26932506.

Abstract | Links | BibTeX | Tags: ENNIFAR, Kinetic Regulation kinITC pyrophosphate riboswitches thiamine, LESCURE, Unité ARN


Lescure A, Castets P, Grunwald D, Allamand V, Howard M

Selenoprotein N: Its role in disease. Book Chapter

In: Hatfield, D; Berry, M; Gladyshev, V (Ed.): Selenium: Its molecular biology and role in human health, pp. 283-294, Springer, 2, 2012.

Abstract | Links | BibTeX | Tags: KROL, LESCURE, Unité ARN


Rudinger-Thirion J, Lescure A, Paulus C, Frugier M

Misfolded human tRNA isodecoder binds and neutralizes a 3' UTR-embedded Alu element Journal Article

In: Proc Natl Acad Sci U S A, vol. 108, no. 40, pp. E794-802, 2011, ISSN: 1091-6490 (Electronic) 0027-8424 (Linking), (Rudinger-Thirion, Joelle Lescure, Alain Paulus, Caroline Frugier, Magali United States Proceedings of the National Academy of Sciences of the United States of America Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):E794-802. Epub 2011 Sep 6.).

Abstract | Links | BibTeX | Tags: FRUGIER, LESCURE, Unité ARN

Rederstorff M, Castets P, Arbogast S, Lainé J, Vassilopoulos S, Beuvin M, Dubourg O, Vignaud A, Ferry A, Krol A, Allamand V, Guicheney P, Ferreiro A, Lescure A

Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. Journal Article

In: PLoS One, vol. 6, no. 8, pp. e23094, 2011, ISBN: 21858002.

Abstract | Links | BibTeX | Tags: KROL, LESCURE, Unité ARN


Lescure A, Rederstorff M, Krol A, Guicheney P, Allamand V

Selenoprotein function and muscle disease Journal Article

In: Biochim Biophys Acta-Gen Subj, vol. 1790, no. 11, pp. 1569-1574, 2009, ISBN: 19285112, (0006-3002 (Print) 0006-3002 (Linking) Journal Article Research Support, Non-U.S. Gov't Review).

Abstract | Links | BibTeX | Tags: Biological Muscle Proteins/genetics/physiology Muscles/physiology Muscular Diseases/*etiology/genetics Mutation/physiology Selenoproteins/genetics/*physiology, KROL Animals Calcium/metabolism Humans Intracellular Fluid/metabolism Models, LESCURE, Unité ARN

Castets P, Maugenre S, Gartioux C, Rederstorff M, Krol A, Lescure A, Tajbakhsh S, Allamand V, Guicheney P

Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors Journal Article

In: BMC Dev Biol, vol. 9, pp. 46, 2009, ISBN: 19698141, (1471-213X (Electronic) 1471-213X (Linking) Journal Article Research Support, Non-U.S. Gov't).

Abstract | Links | BibTeX | Tags: Developmental Humans Mice Muscle Proteins/genetics/*metabolism Muscle, KROL Animals Embryo, LESCURE, Mammalian/metabolism *Gene Expression Regulation, Skeletal/*embryology Myoblasts/metabolism Ryanodine Receptor Calcium Release Channel/metabolism Selenoproteins/genetics/*metabolism Zebrafish/embryology, Unité ARN


Rederstorff M, Allamand V, Guicheney P, Gartioux C, Richard P, Chaigne D, Krol A, Lescure A

Ex vivo correction of selenoprotein N deficiency in rigid spine muscular dystrophy caused by a mutation in the selenocysteine codon Journal Article

In: Nucleic Acids Res, vol. 36, no. 1, pp. 237-244, 2008, ISBN: 18025044, (1362-4962 (Electronic) Journal Article Research Support, Non-U.S. Gov't).

Abstract | Links | BibTeX | Tags: Amino Acid-Specific/*genetics Selenocysteine/metabolism Selenoproteins/biosynthesis/*deficiency/*genetics Transgenes, KROL Codon/chemistry *Codon, LESCURE, Nonsense Fibroblasts/metabolism Hela Cells Humans Muscle Proteins/biosynthesis/*deficiency/*genetics Muscular Atrophy, Spinal/*genetics/metabolism RNA, Transfer, Unité ARN

Lescure A, Deniziak M, Rederstorff M, Krol A

Molecular basis for the role of selenium in muscle development and function Journal Article

In: Chem Biodivers, vol. 5, no. 3, pp. 408-413, 2008, ISBN: 18357550, (1612-1880 (Electronic) Journal Article Research Support, Non-U.S. Gov't).

Links | BibTeX | Tags: KROL, LESCURE, Unité ARN


Rederstorff M, Krol A, Lescure A

Understanding the importance of selenium and selenoproteins in muscle function Journal Article

In: Cell Mol Life Sci, vol. 63, no. 1, pp. 52-59, 2006, ISBN: 16314926, (DOI: 10.1007/s00018-005-5313-y).

Abstract | Links | BibTeX | Tags: KROL Selenium Selenoprotein Muscle disorders Congenital muscular dystrophy SEPN1, LESCURE, Unité ARN

Allamand V, Richard P, Lescure A, Ledeuil C, Desjardin D, Petit N, Gartioux C, Ferreiro A, Krol A, Pellegrini N, Urtizberea J A, Guicheney P

A single homozygous point mutation in a 3'untranslated region motif of selenoprotein N mRNA causes SEPN1-related myopathy Journal Article

In: EMBO Rep, vol. 7, no. 4, pp. 450-454, 2006, ISBN: 16498447, (1469-221X (Print) Journal article).

Abstract | Links | BibTeX | Tags: KROL, LESCURE, Unité ARN


Castellano S, Lobanov A V, Chapple C, Novoselov S V, Albrecht M, Hua D, Lescure A, Lengauer T, Krol A, Gladyshev V N, Guigo R

Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family Journal Article

In: Proc Natl Acad Sci U S A, vol. 102, no. 45, pp. 16188-16193, 2005, ISBN: 16260744, (0027-8424 (Print) Journal Article).

Abstract | Links | BibTeX | Tags: Extramural Research Support, KROL Adenosine Diphosphate Ribose/metabolism Animals Fish Proteins/chemistry/genetics/*physiology Genome Mice NIH 3T3 Cells Phylogeny Promoter Regions (Genetics) Proteome Research Support, LESCURE, N.I.H., Non-P.H.S. Selenoproteins/chemistry/genetics/*physiology Tetraodontiformes/*genetics, Non-U.S. Gov't Research Support, U.S. Gov't, Unité ARN


Jungbluth H, Beggs A, Bonnemann C, Bushby K, Groote C Ceuterick-de, Estournet-Mathiaud B, Goemans N, Guicheney P, Lescure A, Lunardi J, Muntoni F, Quinlivan R, Sewry C, Straub V, Treves S, Ferreiro A

111th ENMC International Workshop on Multi-minicore Disease. 2nd International MmD Workshop, 9-11 November 2002, Naarden, The Netherlands. Journal Article

In: Neuromuscul Disord, vol. 14, no. 11, pp. 754-766, 2004, ISBN: 15482962, (0960-8966 (Print) Congresses Research Support, Non-U.S. Gov't).

Links | BibTeX | Tags: Differential Humans Muscle Fibers/metabolism/*pathology Muscle Proteins/genetics/metabolism Muscle, KROL Diagnosis, LESCURE, Skeletal/metabolism/*pathology/physiopathology Muscular Diseases/classification/genetics/metabolism/*pathology Mutation Ryanodine Receptor Calcium Release Channel/genetics/metabolism Selenoproteins, Unité ARN

Castellano S, Novoselov S V, Kryukov G V, Lescure A, Blanco E, Krol A, Gladyshev V N, Guigo R

Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution Journal Article

In: EMBO Rep, vol. 5, no. 1, pp. 71-77, 2004, ISBN: 14710190, (1469-221x Journal Article).

Abstract | Links | BibTeX | Tags: KROL, LESCURE, Unité ARN


Thisse C, Degrave A, Kryukov G V, Gladyshev V N, Obrecht-Pflumio S, Krol A, Thisse B, Lescure A

Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish Journal Article

In: Gene Expr Patterns, vol. 3, no. 4, pp. 525-532, 2003, ISBN: 12915322, (1567-133x Journal Article).

Abstract | Links | BibTeX | Tags: Animals Gene Expression Regulation, Developmental In Situ Hybridization Molecular Sequence Data Proteins/*genetics/metabolism RNA Probes RNA, LESCURE, Messenger/metabolism Support, Non-U.S. Gov't Support, P.H.S. Tissue Distribution Zebrafish/*embryology, U.S. Gov't, Unité ARN

Petit N, Lescure A, Rederstorff M, Krol A, Moghadaszadeh B, Wewer U M, Guicheney P

Selenoprotein N: an endoplasmic reticulum glycoprotein with an early developmental expression pattern Journal Article

In: Hum Mol Genet, vol. 12, no. 9, pp. 1045-1053, 2003, ISBN: 12700173, (0964-6906 Journal Article).

Abstract | Links | BibTeX | Tags: Cell Division/physiology Endoplasmic Reticulum/*metabolism Fetus/metabolism Fibroblasts/metabolism Human Muscle Proteins/*metabolism Protein Sorting Signals Support, LESCURE, Non-U.S. Gov't, Unité ARN


Lescure A, Gautheret D, Krol A

Novel selenoproteins identified from genomic sequence data Journal Article

In: Methods Enzymol, vol. 347, pp. 57-70, 2002, ISBN: 11898439, (0076-6879 Journal Article).

Links | BibTeX | Tags: 3' Untranslated Regions Animals COS Cells Codon/genetics DNA Transposable Elements DNA, Complementary/genetics Databases, Human Human Nucleic Acid Conformation Proteins/*genetics RNA, LESCURE, Messenger/chemistry/genetics Selenium Radioisotopes Support, Non-U.S. Gov't, Nucleic Acid Genome, Unité ARN

Lescure A, Fagegaltier D, Carbon P, Krol A

Protein factors mediating selenoprotein synthesis Journal Article

In: Curr Protein Pept Sci, vol. 3, no. 1, pp. 143-151, 2002, ISBN: 12370018, (1389-2037 Journal Article Review Review, Tutorial).

Abstract | Links | BibTeX | Tags: Bacterial Proteins/genetics/*metabolism Guanosine Triphosphate/metabolism Models, Biological Peptide Elongation Factors/*metabolism Protein Binding Proteins/*biosynthesis RNA, LESCURE, Messenger/metabolism RNA, Transfer/metabolism RNA-Binding Proteins/*metabolism, Unité ARN

Lescure A, Allmang C, Yamada K, Carbon P, Krol A

cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2 Journal Article

In: Gene, vol. 291, no. 1-2, pp. 279-285, 2002, ISBN: 12095701, (0378-1119 Journal Article).

Abstract | Links | BibTeX | Tags: Amino Acid Support, Amino Acid Sequence Blotting, Complementary/chemistry/genetics Female Gene Expression Human Male Molecular Sequence Data Peptide Elongation Factors/metabolism Protein Binding RNA/*metabolism RNA, DNA Sequence Homology, ERIANI, LESCURE, Messenger/genetics/metabolism RNA-Binding Proteins/genetics/*metabolism Sequence Alignment Sequence Analysis, Molecular DNA, Non-U.S. Gov't, Northern Cloning, Unité ARN

Lambert A, Lescure A, Gautheret D

A survey of metazoan selenocysteine insertion sequences Journal Article

In: Biochimie, vol. 84, no. 9, pp. 953-959, 2002, ISBN: 12458087, (0300-9084 Journal Article).

Abstract | Links | BibTeX | Tags: Animals Base Sequence *Conserved Sequence Databases, Genetic Human Molecular Sequence Data Nucleic Acid Conformation Proteins/*genetics Selenocysteine/*genetics/metabolism Sequence Alignment Sequence Homology, LESCURE, Nucleic Acid Software, Unité ARN


Libri D, Lescure A, Rosbash M

Splicing enhancement in the yeast rp51b intron Journal Article

In: RNA, vol. 6, no. 3, pp. 352-368, 2000, ISBN: 10744020, (1355-8382 Journal Article).

Abstract | Links | BibTeX | Tags: 5' Untranslated Regions/genetics DNA Mutational Analysis Introns/*genetics Multigene Family Nucleic Acid Conformation RNA Splicing/*genetics *Regulatory Sequences, LESCURE, Non-U.S. Gov't Support, Nucleic Acid Ribonucleoprotein, P.H.S. Uridine/metabolism, U.S. Gov't, U1 Small Nuclear/chemistry/genetics Saccharomyces cerevisiae/*genetics Support, Unité ARN

Lescure A, Gautheret D, Fagegaltier D, Carbon P, Krol A

From RNA structure to the identification of new genes: the example of selenoproteins Journal Article

In: J Health Sci, vol. 46, no. 6, pp. 405-408, 2000, ISBN: 01A0078173.

Links | BibTeX | Tags: KROL ACL, LESCURE, Unité ARN

Fagegaltier D, Lescure A, Walczak R, Carbon P, Krol A

Structural analysis of new local features in SECIS RNA hairpins Journal Article

In: Nucleic Acids Res, vol. 28, no. 14, pp. 2679-2689, 2000, ISBN: 10908323, (1362-4962 Journal Article).

Abstract | Links | BibTeX | Tags: Animals Base Sequence COS Cells DNA/chemistry/genetics DNA, DNA Support, Factual Drosophila melanogaster/genetics Glutathione Peroxidase/genetics/metabolism Human Mice Molecular Sequence Data Mutagenesis, LESCURE, Non-U.S. Gov't Xenopus laevis, Nucleic Acid/*genetics Selenocysteine/*genetics/metabolism Sequence Alignment Sequence Analysis, Recombinant/genetics/metabolism Databases, Site-Directed Nucleic Acid Conformation Phosphotransferases/genetics RNA/chemistry/*genetics Rats Regulatory Sequences, Unité ARN


Sturchler C, Lescure A, Keith G, Carbon P, Krol A

Base modification pattern at the wobble position of Xenopus selenocysteine tRNA(Sec) Journal Article

In: Nucleic Acids Res, vol. 22, no. 8, pp. 1354-1358, 1994, ISBN: 8031393, (0305-1048 Journal Article).

Abstract | Links | BibTeX | Tags: Amino Acid-Specific/chemistry/*genetics/metabolism Selenocysteine/*metabolism Support, Animals *Anticodon Base Composition Base Sequence Microinjections Molecular Sequence Data Mutagenesis Nucleic Acid Conformation RNA, LESCURE, Non-U.S. Gov't Uridine Xenopus laevis, Transfer, Unité ARN

Lescure A, Lutz Y, Eberhard D, Jacq X, Krol A, Grummt I, Davidson I, Chambon P, Tora L

The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters Journal Article

In: EMBO J, vol. 13, no. 5, pp. 1166-1175, 1994, ISBN: 7510635, (0261-4189 Journal Article).

Abstract | Links | BibTeX | Tags: Antibodies, Genetic, LESCURE, Non-U.S. Gov't *TATA Box TATA-Box Binding Protein Transcription Factor TFIIA Transcription Factor TFIIB Transcription Factor TFIID Transcription Factors/biosynthesis/isolation & purification/*metabolism *Transcription, Unité ARN


Lescure A, Tebb G, Mattaj I W, Krol A, Carbon P

A factor with Sp1 DNA-binding specificity stimulates Xenopus U6 snRNA in vivo transcription by RNA polymerase III Journal Article

In: J Mol Biol, vol. 228, no. 2, pp. 387-394, 1992, ISBN: 1453450, (0022-2836 Journal Article).

Abstract | Links | BibTeX | Tags: Animals Base Sequence Binding Sites Dna Molecular Sequence Data RNA Polymerase III/*metabolism RNA, Genetic Xenopus, LESCURE, Non-U.S. Gov't Transcription Factor, Nucleic Acid Support, Small Nuclear/*genetics *Regulatory Sequences, Sp1/metabolism *Transcription, Unité ARN

Lescure A, Murgo S, Carbon P, Krol A

The proximal promoter and the start site cooperate to specify correct U1 snRNA transcription initiation by RNA polymerase II Journal Article

In: Nucleic Acids Res, vol. 20, no. 7, pp. 1573-1578, 1992, ISBN: 1579449, (0305-1048 Journal Article).

Abstract | Links | BibTeX | Tags: Animals Base Sequence DNA/metabolism DNA Mutational Analysis Molecular Sequence Data Promoter Regions (Genetics)/*genetics RNA Polymerase II/*metabolism RNA, Genetic/*genetics Xenopus laevis/genetics, KROL, LESCURE, Non-U.S. Gov't Transcription, Small Nuclear/*genetics Support, Unité ARN