Biologie Digitale de l’ARN

@article{chamouard_diminution_2009,

title = {Diminution of Circulating CD4+CD25 high Ŧ cells in naïve Crohn's disease},

author = {Patrick Chamouard and Fanny Monneaux and Zoe Richert and Anne-Claire Voegeli and Thomas Lavaux and Marie Pierre Gaub and René Baumann and Pierre Oudet and Sylviane Muller},

doi = {10.1007/s10620-008-0590-6},

issn = {1573-2568},

year  = {2009},

date = {2009-10-01},

journal = {Digestive Diseases and Sciences},

volume = {54},

number = {10},

pages = {2084--2093},

abstract = {Crohn's disease is considered to be caused either by an excess of T-cell effector functions and/or by a defective regulatory T-cell compartment. The aim of this study was to assess in Crohn's disease the frequency of circulating CD4(+)CD25(high) T cells that possess regulatory T-cell functions and CD4(+)CD25(low) T cells that contain activated T cells. Flow cytometry of peripheral blood was used to assess CD4(+)CD25(high) and CD4(+)CD25(low) T-cell frequencies in a cohort of 66 patients with Crohn's disease in comparison to 19 patients with ulcerative colitis and 31 healthy individuals enrolled as controls. The CD4(+)CD25(high) T-cell frequency was significantly lowered in naïve Crohn's disease (P = 0.013) and in ulcerative colitis (P = 0.001). CD4(+)CD25(low) T-cell frequency was increased in Crohn's disease (P = 0.0001) and in ulcerative colitis (P = 0.0002). Both CD4(+)CD25(high) and CD4(+)CD25(low) T-cell frequencies are altered in naïve Crohn's disease resulting in an imbalance between both populations and a relative contraction of the CD4(+)CD25(high) T-cell population.},

keywords = {Adult, Aged, Blood Cell Count, CD4 Antigens, Colitis, Crohn Disease, Female, Flow Cytometry, Humans, I2CT, Interleukin-2 Receptor alpha Subunit, Lymphocyte Subsets, Male, Middle Aged, Monneaux, Regulatory, T-Lymphocytes, Team-Dumortier, Ulcerative},

pubstate = {published},

tppubtype = {article}

}

@article{hoffmann_modifications_1974,

title = {Modifications of the hemogram and of the hemocytopoietic tissue of male adults of Locusta migratoria (Orthoptera) after injection of Bacillus thuringiensis},

author = {Danièle Hoffmann and M Brehelin and Jules A Hoffmann},

issn = {0022-2011},

year  = {1974},

date = {1974-09-01},

journal = {J. Invertebr. Pathol.},

volume = {24},

number = {2},

pages = {238--247},

keywords = {Bacillus, Blood Cell Count, Grasshoppers, Hematopoietic System, hoffmann, M3i},

pubstate = {published},

tppubtype = {article}

}