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Publications

2022

Geraci I., Autour A., Pietruschka G., Shiian A., Borisova M., Mayer C., Ryckelynck M., Mayer G.

Fluorogenic RNA-Based Biosensor to Sense the Glycolytic Flux in Mammalian Cells Article de journal

Dans: ACS Chem Biol, 2022, ISBN: 35427113, (1554-8937 (Electronic) 1554-8929 (Linking) Journal Article).

Résumé | Liens | BibTeX | Étiquettes: Labex, RYCKELYNCK, Unité ARN

Fam K. T., Pelletier R., Bouhedda F., Ryckelynck M., Collot M., Klymchenko A. S.

Rational Design of Self-Quenched Rhodamine Dimers as Fluorogenic Aptamer Probes for Live-Cell RNA Imaging Article de journal

Dans: Anal Chem, p. in press, 2022, ISBN: 35486532, (1520-6882 (Electronic) 0003-2700 (Linking) Journal Article).

Résumé | Liens | BibTeX | Étiquettes: Labex, RYCKELYNCK, Unité ARN

Geersens E., Vuilleumier S., Ryckelynck M.

Growth-Associated Droplet Shrinkage for Bacterial Quantification, Growth Monitoring, and Separation by Ultrahigh-Throughput Microfluidics Article de journal

Dans: ACS Omega, vol. 7, no. 14, p. 12039-12047, 2022, ISBN: 35449964, (2470-1343 (Electronic) 2470-1343 (Linking) Journal Article).

Résumé | Liens | BibTeX | Étiquettes: Labex, RYCKELYNCK, Unité ARN

2021

Husser C, Dentz N, Ryckelynck M

Structure-Switching RNAs: From Gene Expression Regulation to Small Molecule Detection Article de journal

Dans: Small Structures, vol. 2, no. 4, p. 2000132, 2021.

Résumé | Liens | BibTeX | Étiquettes: biosensing, Gene Expression Regulation, riboswitches, RNA aptamers, RYCKELYNCK, Synthetic Biology, Unité ARN

Bouhedda F, Cubi R, Baudrey S, Ryckelynck M

microIVC-Seq: A Method for Ultrahigh-Throughput Development and Functional Characterization of Small RNAs Chapitre d'ouvrage

Dans: Rederstorff, M (Ed.): Small Non-Coding RNAs, vol. 2300, p. 203-237, Springer Protocols, Humana Press, New York, NY, Small Non-Coding RNAs, 2021, ISBN: 978-1-0716-1385-6/ISSN, (1940-6029 (Electronic) 1064-3745 (Linking) Journal Article).

Résumé | Liens | BibTeX | Étiquettes: Artificial RNAs, directed evolution, Droplet microfluidics, Functional screening, In vitro selection, RNA, RYCKELYNCK, RYCKELYNCK Artificial RNAs, Unité ARN

Cubi R, Bouhedda F, Collot M, Klymchenko A S, Ryckelynck M

microIVC-Useq: a microfluidic-assisted high-throughput functionnal screening in tandem with next generation sequencing and artificial neural network to rapidly characterize RNA molecules Article de journal

Dans: Rna, vol. 27, no. 7, p. 841-853, 2021, ISBN: 33952671, (1469-9001 (Electronic) 1355-8382 (Linking) Journal Article).

Résumé | Liens | BibTeX | Étiquettes: Bioinformatics, droplet-based microfluidics, high-throughput screening, light-up RNA aptamer, RNA engineering, RYCKELYNCK, Unité ARN

Singh G., Pereira D., Baudrey S., Hoffmann E., Ryckelynck M., Asnacios A., Chaboute M. E.

Real-time tracking of root hair nucleus morphodynamics using a microfluidic approach Article de journal

Dans: Plant J, vol. 108, iss. 2, p. 303-313, 2021, ISBN: 34562320, (1365-313X (Electronic) 0960-7412 (Linking) Journal Article).

Résumé | Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN

Bouhedda F., Ryckelynck M.

Compartmentalization-based technologies for in vitro selection and evolution of ribozymes and light-up RNA aptamers Chapitre d'ouvrage

Dans: & B. Masquida S. Müller, W. Winkler (Ed.): Ribozymes, vol. 28, p. 721-738, John Wiley & Sons, Ltd, 2021.

Résumé | Liens | BibTeX | Étiquettes: catalytic RNAs, Droplet microfluidics, fluorescence, in vitro evolution, In vitro selection, light-up RNA aptamers, ribozymes, RYCKELYNCK, screening, Unité ARN

2020

Hayoun K, Geersens E, Laczny C C, Halder R, Sánchez C Lázaro, Manna A, Bringel F, Ryckelynck M, Muller P Wilmesand E E L, Alpha-Bazin B, Armengaud J, Vuilleumier S

Dichloromethane Degradation Pathway from Unsequenced Hyphomicrobium sp. MC8b Rapidly Explored by Pan-Proteomics Article de journal

Dans: Microorganisms, vol. 8, no. 12, p. E1876, 2020.

Résumé | Liens | BibTeX | Étiquettes: dcm genes, dehalogenation, dichloromethane, differential proteomics, genome sequencing, Hyphomicrobium, Nanopore, pan-proteomics, RYCKELYNCK, Unité ARN

Ryckelynck M

Development and Applications of Fluorogen/Light-Up RNA Aptamer Pairs for RNA Detection and More Chapitre d'ouvrage

Dans: vol. 2166, p. 73-102, Methods in Molecular Biology, 2020.

Résumé | Liens | BibTeX | Étiquettes: aptamer, biosensing, Engineering, fluorogen, Functional screening, Live-cell imaging, RNA, RYCKELYNCK, SELEX, Unité ARN

3rd R J Trachman, Cojocaru R, Wu D, Piszczek G, Ryckelynck M, Unrau P J, Ferré-D'Amaré A R

Structure-Guided Engineering of the Homodimeric Mango-IV Fluorescence Turn-on Aptamer Yields an RNA FRET Pair Article de journal

Dans: Structure, vol. 28, no. 7, p. 776-785.e773, 2020, ISBN: 32386573.

Résumé | Liens | BibTeX | Étiquettes: RNA aptamer RNA fluorescence RNA structure fluorescent dye structure-guided engineering, RYCKELYNCK, Unité ARN

Pernod K, Schaeffer L, Chicher J, Hok E, Rick C, Geslain R, Eriani G, Westhof E, Ryckelynck M, Martin F

The Nature of the Purine at Position 34 in tRNAs of 4-codon Boxes Is Correlated With Nucleotides at Positions 32 and 38 to Maintain Decoding Fidelity Article de journal

Dans: Nucleic Acids Res, vol. 48, no. 11, p. 6170-6183, 2020, ISBN: 32266934.

Résumé | Liens | BibTeX | Étiquettes: ERIANI, PPSE, RYCKELYNCK, Unité ARN, WESTHOF

Bouhedda F, Fam K T, Collot M, Autour A, Marzi S, Klymchenko A, Ryckelynck M

A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells Article de journal

Dans: Nat Chem Biol, vol. 16, no. 1, p. 69-76, 2020, ISBN: 31636432.

Résumé | Liens | BibTeX | Étiquettes: ROMBY, RYCKELYNCK, Unité ARN

2019

3rd R J Trachman, Autour A, Jeng S C Y, Abdolahzadeh A, Andreoni A, Cojocaru R, Garipov R, Dolgosheina E V, Knutson J R, Ryckelynck M, Unrau P J, Ferré-D'Amaré A R

Structure and functional reselection of the Mango-III fluorogenic RNA aptamer Article de journal

Dans: Nat Chem Biol, vol. 15, no. 5, p. 472-479, 2019, ISBN: 30992561.

Résumé | Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN

Ryckelynck M

Development and engineering of artificial RNAs Article de journal

Dans: Methods, vol. 161, p. 1-2, 2019, ISBN: 31195094.

Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN

Autour A, Bouhedda F, Cubi R, Ryckelynck M

Optimization of fluorogenic RNA-based biosensors using droplet-based microfluidic ultrahigh-throughput screening Article de journal

Dans: Methods, vol. 161, p. 46-53, 2019, ISBN: 30902664.

Résumé | Liens | BibTeX | Étiquettes: Aptasensors Fluorogenic biosensors High-throughput screening Light-up aptamer Next generation sequencing RNA, RYCKELYNCK, Unité ARN

2018

3rd R J Trachman, Abdolahzadeh A, Andreoni A, Cojocaru R, Knutson J R, Ryckelynck M, Unrau P J, Ferré-D'Amaré A R

Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness Article de journal

Dans: Biochemistry, vol. 57, no. 26, p. 3544-3548, 2018, ISBN: 29768001.

Résumé | Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN

Bouhedda F, Autour A, Ryckelynck M

Light-Up RNA Aptamers and Their Cognate Fluorogens: From Their Development to Their Applications Article de journal

Dans: Int J Mol Sci, vol. 19, no. 1, p. 44, 2018, ISBN: 29295531.

Résumé | Liens | BibTeX | Étiquettes: RNA biosensing fluorescence fluorogen fluorogenic dye gene expression monitoring in vitro evolution light-up aptamer live-cell imaging, RYCKELYNCK, Unité ARN

Autour A, Jeng S C Y, Cawte A D, Abdolahzadeh A, Galli A, Panchapakesan SSS., Rueda D, Ryckelynck M, Unrau P J

Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells Article de journal

Dans: Nat Commun, vol. 9, no. 1, p. 656, 2018, ISBN: 29440634.

Résumé | Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN

2017

Autour A, Ryckelynck M

Ultrahigh-Throughput Improvement and Discovery of Enzymes Using Droplet-Based Microfluidic Screening Article de journal

Dans: Micromachines, vol. 8, no. 4, p. 128, 2017.

Résumé | Liens | BibTeX | Étiquettes: directed evolution, droplet-based microfluidics, enzyme improvement, high-throughput screening, RYCKELYNCK, single-cell, Unité ARN

Fernandez-Millan P, Autour A, Ennifar E, Westhof E, Ryckelynck M

Crystal structure and fluorescence properties of the iSpinach aptamer in complex with DFHBI Article de journal

Dans: RNA, vol. 23, no. 12, p. 1788-1795, 2017, ISBN: 28939697.

Résumé | Liens | BibTeX | Étiquettes: DFHBI Spinach crystal structure fluorescence fluorogenic RNA aptamer, ENNIFAR, RYCKELYNCK, Unité ARN, WESTHOF

2016

Autour A, Westhof E, Ryckelynck M

iSpinach: a fluorogenic RNA aptamer optimized for in vitro applications. Article de journal

Dans: Nucleic Acids Res, vol. 44, no. 6, p. 2491-2500, 2016, ISBN: 26932363.

Résumé | Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN, WESTHOF

Matsumura S, Kun A, Ryckelynck M, Coldren F, Szilagyi A, Jossinet F, Rick C, Nghe P, Szathmary E, Griffiths A D

Transient compartmentalization of RNA replicators prevents extinction due to parasites. Article de journal

Dans: Science, vol. 354, no. 6317, p. 1293-1296, 2016, ISBN: 27940874.

Résumé | Liens | BibTeX | Étiquettes: RYCKELYNCK, Unité ARN

2015

Woronoff G, Ryckelynck M, Wessel J, Schicke O, Griffiths A, P. Soumillion

Activity-Fed Translation (AFT) Assay: A New High-Throughput Screening Strategy for Enzymes in Droplets. Article de journal

Dans: Chembiochem, vol. 16, no. 9, p. 1343-1349, 2015.

Résumé | Liens | BibTeX | Étiquettes: droplet-based microfluidics enzyme catalysis in vitro translation penicillin acylase protein expression, RYCKELYNCK, Unité ARN

Ryckelynck M, Baudrey S, Rick C, Marin A, Coldren F, Westhof E, Griffiths A D

Using droplet-based microfluidics to improve the catalytic properties of RNA under multiple-turnover conditions. Article de journal

Dans: RNA, vol. 21, no. 3, p. 458-469, 2015, ISBN: 25605963.

Résumé | Liens | BibTeX | Étiquettes: RNA droplet-based microfluidics high-throughput screening in vitro evolution ribozymes, RYCKELYNCK, Unité ARN, WESTHOF