RNA interference and receptors

@article{ji_physically-triggered_2019,

title = {Physically-triggered nanosystems based on two-dimensional materials for cancer theranostics},

author = {Ding-Kun Ji and Cécilia Ménard-Moyon and Alberto Bianco},

doi = {10.1016/j.addr.2018.08.010},

issn = {1872-8294},

year  = {2019},

date = {2019-01-01},

journal = {Advanced Drug Delivery Reviews},

volume = {138},

pages = {211--232},

abstract = {There is an increasing demand to develop effective methods for treating malignant diseases to improve healthcare in our society. Stimuli-responsive nanosystems, which can respond to internal or external stimuli are promising in cancer therapy and diagnosis due to their functionality and versatility. As a newly emerging class of nanomaterials, two-dimensional (2D) nanomaterials have attracted huge interest in many different fields including biomedicine due to their unique physical and chemical properties. In the past decade, stimuli-responsive nanosystems based on 2D nanomaterials have been widely studied, showing promising applications in cancer therapy and diagnosis, including phototherapies, magnetic therapy, drug and gene delivery, and non-invasive imaging. Here, we will focus our attention on the state-of-the-art of physically-triggered nanosystems based on graphene and two-dimensional nanomaterials for cancer therapy and diagnosis. The physical triggers include light, temperature, magnetic and electric fields.},

keywords = {2D Materials, Animals, Diagnosis, graphene, Graphite, Humans, I2CT, Light, Magnetic Fields, Nanomaterials, Nanostructures, Neoplasms, Team-Bianco, Theragnosis, Theranostic Nanomedicine, therapy},

pubstate = {published},

tppubtype = {article}

}

@article{russier_few-layer_2017,

title = {Few-Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients},

author = {Julie Russier and Verónica León and Marco Orecchioni and Eri Hirata and Patrizia Virdis and Claudio Fozza and Francesco Sgarrella and Gianaurelio Cuniberti and Maurizio Prato and Ester Vázquez and Alberto Bianco and Lucia G Delogu},

doi = {10.1002/anie.201700078},

issn = {1521-3773},

year  = {2017},

date = {2017-01-01},

journal = {Angewandte Chemie (International Ed. in English)},

volume = {56},

number = {11},

pages = {3014--3019},

abstract = {In the cure of cancer, a major cause of today's mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few-layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches.},

keywords = {Acute, cancer therapy, Chronic, Cultured, graphene, Graphite, Humans, I2CT, Immune System, leukemia, Leukocytes, Mononuclear, Myeloid, Myelomonocytic, myelomonocytic leukemia, Nanomaterials, Particle Size, Surface Properties, Team-Bianco, Tumor Cells},

pubstate = {published},

tppubtype = {article}

}

@article{servant_graphene_2014,

title = {Graphene for multi-functional synthetic biology: the last 'zeitgeist' in nanomedicine},

author = {A Servant and A Bianco and M Prato and K Kostarelos},

doi = {10.1016/j.bmcl.2014.01.051},

issn = {1464-3405},

year  = {2014},

date = {2014-01-01},

journal = {Bioorganic & Medicinal Chemistry Letters},

volume = {24},

number = {7},

pages = {1638--1649},

abstract = {The high versatility of graphene has attracted significant attention in many areas of scientific research from electronics to physics and mechanics. One of the most intriguing utilisation of graphene remains however in nanomedicine and synthetic biology. In particular, the last decade has witnessed an exponential growth in the generation of novel candidate therapeutics of multiple biological activities based on graphene constructs with small molecules, such as anti-cancer drugs. In this Digest, we summarise the different synthetic strategies and routes available to fabricate these promising graphene conjugates and the opportunities for the design of multi-functional tools for synthetic biology that they offer.},

keywords = {Antineoplastic Agents, carbon, Drug delivery, Drug Design, Graphite, I2CT, Nanomaterials, Nanomedicine, nanotechnology, Synthetic Biology, Team-Bianco},

pubstate = {published},

tppubtype = {article}

}

@article{lacerda_dynamic_2008,

title = {Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion},

author = {L Lacerda and A Soundararajan and R Singh and G Pastorin and K T Al‐Jamal and J Turton and P Frederik and M A Herrero and S Li and A Bao and D Emfietzoglou and S Mather and W T Phillips and M Prato and A Bianco and B Goins and K Kostarelos},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.200702334},

doi = {10.1002/adma.200702334},

issn = {1521-4095},

year  = {2008},

date = {2008-01-01},

urldate = {2020-03-31},

journal = {Advanced Materials},

volume = {20},

number = {2},

pages = {225--230},

abstract = {Intravenously administered multi-walled carbon nanotubes, functionalized with DTPA and radiolabeled with Indium-111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation and within 5 min begin to permeate through the renal glomerular filtration system into the bladder.},

keywords = {Biomedical applications, Carbon nanotubes, I2CT, multiwalled, Nanomaterials, Team-Bianco},

pubstate = {published},

tppubtype = {article}

}