Réponses antivirales chez le moustique Aedes

@article{paro_sensing_2015,

title = {Sensing viral RNAs by Dicer/RIG-I like ATPases across species},

author = {Simona Paro and Jean-Luc Imler and Carine Meignin},

url = {http://linkinghub.elsevier.com/retrieve/pii/S0952791515000102},

doi = {10.1016/j.coi.2015.01.009},

issn = {1879-0372},

year  = {2015},

date = {2015-02-01},

journal = {Current Opinion in Immunology},

volume = {32},

pages = {106--113},

abstract = {Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex RNA activated ATPase, or DRA domain, plays an important role in viral RNA sensing. Crystallographic and electron microscopy studies of the RIG-I and Dicer DRA domains indicate a common structure and that similar conformational changes are induced by dsRNA binding. Genetic and biochemical studies on the function and regulation of DRAs reveal similarities, but also some differences, between viral RNA sensing mechanisms in nematodes, flies and mammals.},

keywords = {Adenosine Triphosphatases, Animals, DEAD-box RNA Helicases, Humans, imler, M3i, meignin, Protein Binding, Protein Interaction Domains and Motifs, Ribonuclease III, RNA, Viral, Virus Diseases, viruses},

pubstate = {published},

tppubtype = {article}

}

@article{kemp_antiviral_2009,

title = {Antiviral immunity in drosophila},

author = {Cordula Kemp and Jean-Luc Imler},

doi = {10.1016/j.coi.2009.01.007},

issn = {1879-0372},

year  = {2009},

date = {2009-02-01},

journal = {Current Opinion in Immunology},

volume = {21},

number = {1},

pages = {3--9},

abstract = {Genetic analysis of the drosophila antiviral response indicates that RNA interference plays a major role. This contrasts with the situation in mammals, where interferon-induced responses mediate innate antiviral host-defense. An inducible response also contributes to antiviral immunity in drosophila, and similarities in the sensing and signaling of viral infection are becoming apparent between drosophila and mammals. In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals.},

keywords = {Animals, Argonaute Proteins, Caspases, DEAD-box RNA Helicases, Evolution, Gene Expression Regulation, Host-Pathogen Interactions, imler, M3i, Membrane Proteins, Molecular, Nuclear Proteins, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Virus Infections, RNA Viruses, RNA-Induced Silencing Complex, Viral, Virulence},

pubstate = {published},

tppubtype = {article}

}

@article{deddouche_dexd/h-box_2008,

title = {The DExD/Ħ-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila},

author = {Safia Deddouche and Nicolas Matt and Aidan Budd and Stefanie Mueller and Cordula Kemp and Delphine Galiana-Arnoux and Catherine Dostert and Christophe Antoniewski and Jules A Hoffmann and Jean-Luc Imler},

doi = {10.1038/ni.1664},

issn = {1529-2916},

year  = {2008},

date = {2008-12-01},

journal = {Nature Immunology},

volume = {9},

number = {12},

pages = {1425--1432},

abstract = {Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/H-box helicase family as do the RIG-I-like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.},

keywords = {Amino Acid, Animals, Electrophoresis, Fat Body, Gene Expression Regulation, Genetic, Genetically Modified, hoffmann, Humans, imler, M3i, matt, Phylogeny, Polyacrylamide Gel, Reverse Transcriptase Polymerase Chain Reaction, Ribonuclease III, RNA Helicases, Sequence Homology, Transcription, Virus Diseases},

pubstate = {published},

tppubtype = {article}

}

@article{muller_dicing_2007,

title = {Dicing with viruses: microRNAs as antiviral factors},

author = {Stefanie Müller and Jean-Luc Imler},

doi = {10.1016/j.immuni.2007.07.003},

issn = {1074-7613},

year  = {2007},

date = {2007-07-01},

journal = {Immunity},

volume = {27},

number = {1},

pages = {1--3},

abstract = {In plants and invertebrates, Dicer genes play a critical role against infections by RNA viruses. In this issue, Otsuka et al. (2007) report that Dicer mutant mice are hypersusceptible to infection by the RNA virus VSV.},

keywords = {Animals, DEAD-box RNA Helicases, Endoribonucleases, imler, M3i, MicroRNAs, Ribonuclease III, RNA Interference, RNA Virus Infections},

pubstate = {published},

tppubtype = {article}

}

@article{galiana-arnoux_essential_2006,

title = {Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila},

author = {Delphine Galiana-Arnoux and Catherine Dostert and Anette Schneemann and Jules A Hoffmann and Jean-Luc Imler},

doi = {10.1038/ni1335},

issn = {1529-2908},

year  = {2006},

date = {2006-06-01},

journal = {Nature Immunology},

volume = {7},

number = {6},

pages = {590--597},

abstract = {The fruit fly Drosophila melanogaster is a model system for studying innate immunity, including antiviral host defense. Infection with drosophila C virus triggers a transcriptional response that is dependent in part on the Jak kinase Hopscotch. Here we show that successful infection and killing of drosophila with the insect nodavirus flock house virus was strictly dependent on expression of the viral protein B2, a potent inhibitor of processing of double-stranded RNA mediated by the essential RNA interference factor Dicer. Conversely, flies with a loss-of-function mutation in the gene encoding Dicer-2 (Dcr-2) showed enhanced susceptibility to infection by flock house virus, drosophila C virus and Sindbis virus, members of three different families of RNA viruses. These data demonstrate the importance of RNA interference for controlling virus replication in vivo and establish Dcr-2 as a host susceptibility locus for virus infections.},

keywords = {Animals, Genetically Modified, hoffmann, imler, M3i, Mutation, Nodaviridae, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Viruses, Viral, Viral Proteins, Virus Replication},

pubstate = {published},

tppubtype = {article}

}