Viruses transmitted by arthropod vectors (arboviruses) such as dengue and Zika pose a major public health problem around the world. The incidence of dengue fever alone has increased 30-fold over the past 50 years, and 400 million new infections are reported annually. We lack effective vaccines and treatments against mosquito-borne viruses, and most public health measures are based on controlling the vector population. Although mosquitoes play a central role in the transmission of these viruses, the effectiveness and impact of vector control remains uncertain. In this context, mosquitoes have a natural antiviral resistance that could be explored in order to prevent the transmission of arboviruses.