Imagerie

@article{samori_enhanced_2010,

title = {Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers},

author = {Cristian Samorì and Hanene Ali-Boucetta and Raquel Sainz and Chang Guo and Francesca Maria Toma and Chiara Fabbro and Tatiana da Ros and Maurizio Prato and Kostas Kostarelos and Alberto Bianco},

doi = {10.1039/b923560d},

issn = {1364-548X},

year  = {2010},

date = {2010-03-01},

journal = {Chemical Communications (Cambridge, England)},

volume = {46},

number = {9},

pages = {1494--1496},

abstract = {Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.},

keywords = {Antineoplastic Agents, Azo Compounds, carbon, Cell Line, Cross-Linking Reagents, Humans, I2CT, Methotrexate, Nanotubes, Team-Bianco, Thiosemicarbazones, tumor},

pubstate = {published},

tppubtype = {article}

}

@article{herrero_synthesis_2009,

title = {Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery},

author = {Antonia M Herrero and Francesca M Toma and Khuloud T Al-Jamal and Kostas Kostarelos and Alberto Bianco and Tatiana Da Ros and Fouzia Bano and Loredana Casalis and Giacinto Scoles and Maurizio Prato},

doi = {10.1021/ja903316z},

issn = {1520-5126},

year  = {2009},

date = {2009-07-01},

journal = {Journal of the American Chemical Society},

volume = {131},

number = {28},

pages = {9843--9848},

abstract = {A new series of dendron-functionalized multiwalled carbon nanotube (MWNT) derivatives, characterized by the presence of numerous positively charged tetraalkyl ammonium salts at the periphery of the dendron, has been synthesized. The positive charges on the MWNT surface, coupled with the unique ability of carbon nanotubes (CNTs) to penetrate cell membranes, make the new derivatives potentially ideal vectors for siRNA delivery. Using a fluorescently labeled, noncoding siRNA sequence, we demonstrate that cytoplasmic delivery of the nucleic acid is remarkably increased throughout the different dendron generations. The work reported here highlights the fact that dendron-functionalized CNTs can be rationally designed as efficient carriers of siRNA that can eventually lead to gene silencing.},

keywords = {Acrylates, Animals, Azo Compounds, Biological Transport, carbon, Cytoplasm, Dendrimers, Drug Carriers, Ethylenediamines, Gene Silencing, HeLa Cells, Humans, I2CT, Nanotubes, Polyamines, RNA, Small Interfering, Solubility, Team-Bianco, Thiosemicarbazones, Transfection, water},

pubstate = {published},

tppubtype = {article}

}