Navet Benjamin, Vargas-Franco Jorge William, Gama Andrea, Amiaud Jérome, Choi Yongwon, Yagita Hideo, Mueller Christopher G, Rédini Françoise, Heymann Dominique, Castaneda Beatriz, Lézot Frédéric
Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups Article de journal
Dans: Journal of Clinical Medicine, vol. 7, no. 11, 2018, ISSN: 2077-0383.
Résumé | Liens | BibTeX | Étiquettes: bone, mandible, Morphogenesis, OSTEOCLAST, RANKL, skeletal growth, Team-Mueller, Tooth
@article{navet_maternal_2018,
title = {Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups},
author = {Benjamin Navet and Jorge William Vargas-Franco and Andrea Gama and Jérome Amiaud and Yongwon Choi and Hideo Yagita and Christopher G Mueller and Françoise Rédini and Dominique Heymann and Beatriz Castaneda and Frédéric Lézot},
doi = {10.3390/jcm7110426},
issn = {2077-0383},
year = {2018},
date = {2018-11-01},
journal = {Journal of Clinical Medicine},
volume = {7},
number = {11},
abstract = {RANKL signalization is implicated in the morphogenesis of various organs, including the skeleton. Mice invalidated for Rankl present an osteopetrotic phenotype that was less severe than anticipated, depending on RANKL's implication in morphogenesis. The hypothesis of an attenuated phenotype, as a result of compensation during gestation by RANKL of maternal origin, was thus brought into question. In order to answer this question, Rankl null mutant pups from null mutant parents were generated, and the phenotype analyzed. The results validated the presence of a more severe osteopetrotic phenotype in the second-generation null mutant with perinatal lethality. The experiments also confirmed that RANKL signalization plays a part in the morphogenesis of skeletal elements through its involvement in cell-to-cell communication, such as in control of osteoclast differentiation. To conclude, we have demonstrated that the phenotype associated with Rankl invalidation is attenuated through compensation by RANKL of maternal origin.},
keywords = {bone, mandible, Morphogenesis, OSTEOCLAST, RANKL, skeletal growth, Team-Mueller, Tooth},
pubstate = {published},
tppubtype = {article}
}
Navet Benjamin, Ando Kosei, Vargas-Franco Jorge William, Brion Régis, Amiaud Jérome, Mori Kanji, Yagita Hideo, Mueller Christopher G, Verrecchia Franck, Dumars Clotilde, Heymann Marie-Françoise, Heymann Dominique, Lézot Frédéric
The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases Article de journal
Dans: Cancers, vol. 10, no. 11, 2018, ISSN: 2072-6694.
Résumé | Liens | BibTeX | Étiquettes: bone, metastases, osteosarcoma, RANKL/RANK, T-Lymphocyte, Team-Mueller
@article{navet_intrinsic_2018,
title = {The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases},
author = {Benjamin Navet and Kosei Ando and Jorge William Vargas-Franco and Régis Brion and Jérome Amiaud and Kanji Mori and Hideo Yagita and Christopher G Mueller and Franck Verrecchia and Clotilde Dumars and Marie-Françoise Heymann and Dominique Heymann and Frédéric Lézot},
doi = {10.3390/cancers10110398},
issn = {2072-6694},
year = {2018},
date = {2018-10-01},
journal = {Cancers},
volume = {10},
number = {11},
abstract = {Background: Osteosarcoma is the most frequent form of malignant pediatric bone tumor. Despite the current therapeutic arsenal, patient life-expectancy remains low if metastases are detected at the time of diagnosis, justifying research into better knowledge at all stages of osteosarcoma ontogenesis and identification of new therapeutic targets. Receptor Activator of Nuclear factor κB (RANK)expression has been reported in osteosarcoma cells, raising the question of Receptor Activator of Nuclear factor κB Ligand (RANKL)/RANK signaling implications in these tumor cells (intrinsic), in addition to previously reported implications through osteoclast activation in the tumor microenvironment (extrinsic). Methods: Based on in vitro and in vivo experimentations using human and mouse osteosarcoma cell lines, the consequences on the main cellular processes of RANK expression in osteosarcoma cells were analyzed. Results: The results revealed that RANK expression had no impact on cell proliferation and tumor growth, but stimulated cellular differentiation and, in an immune-compromised environment, increased the number of lung metastases. The analysis of RANKL, RANK and osteoprotegerin (OPG) expressions in biopsies of a cohort of patients revealed that while RANK expression in osteosarcoma cells was not significantly different between patients with or without metastases at the time of diagnosis, the OPG/RANK ratio decreased significantly. Conclusion: Altogether, these results are in favor of RANKL-RANK signaling inhibition as an adjuvant for the treatment of osteosarcoma.},
keywords = {bone, metastases, osteosarcoma, RANKL/RANK, T-Lymphocyte, Team-Mueller},
pubstate = {published},
tppubtype = {article}
}