Ciobanu M, Huang K T, Daguer J P, Barluenga S, Chaloin O, Schaeffer E, Mueller C G, Mitchell D A, Winssinger N
Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells Article de journal
@article{ciobanu_selection_2011,
title = {Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells},
author = {M Ciobanu and K T Huang and J P Daguer and S Barluenga and O Chaloin and E Schaeffer and C G Mueller and D A Mitchell and N Winssinger},
year = {2011},
date = {2011-07-01},
journal = {Chem.Commun.(Camb.)},
number = {1364-548X (Electronic)},
abstract = {We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan},
keywords = {Dendritic Cells, GP120, HIV, IDENTIFICATION, inhibition, ligand, mannan, synthesis, Team-Mueller},
pubstate = {published},
tppubtype = {article}
}
We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37 485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan