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Modèles Insectes d’Immunité Innée
Publications
2005
Kostarelos K, Lacerda L, Partidos C D, Prato M, Bianco A
Carbon nanotube-mediated delivery of peptides and genes to cells: translating nanobiotechnology to therapeutics Article de journal
Dans: Journal of Drug Delivery Science and Technology, vol. 15, no. 1, p. 41–47, 2005, ISSN: 1773-2247.
Résumé | Liens | BibTeX | Étiquettes: Carbon nanotubes, gene delivery, gene therapy, I2CT, Nanomedicine, Peptide delivery, Team-Bianco, Vaccination
@article{kostarelos_carbon_2005,
title = {Carbon nanotube-mediated delivery of peptides and genes to cells: translating nanobiotechnology to therapeutics},
author = {K Kostarelos and L Lacerda and C D Partidos and M Prato and A Bianco},
url = {http://www.sciencedirect.com/science/article/pii/S1773224705500054},
doi = {10.1016/S1773-2247(05)50005-4},
issn = {1773-2247},
year = {2005},
date = {2005-01-01},
urldate = {2020-03-31},
journal = {Journal of Drug Delivery Science and Technology},
volume = {15},
number = {1},
pages = {41--47},
abstract = {During the last few years, there has been a tremendous amount of optimism and expectation about nanotechnology and its impact on various fields including medicine and pharmaceutical development. One of the most promising materials being developed during the nanotechnological renaissance we are currently experiencing is the carbon nanotube. Before any biology-related application can even be envisaged, the aqueous solubility of carbon nanotubes has to be resolved. Recently, a variety of methodologies have been proposed which lead to biologically compatible carbon nanotubes. Covalent functionalization of their surface is one methodology, allowing the first attempts towards applications in the field of nanomedicine. The possibility of incorporating functionalized carbon nanotubes into cells and the biological milieu offers numerous advantages for potential applications in biology and pharmacology. One of the most promising is their utilization as a new carrier system for the delivery of therapeutic molecules. In the present article, the first attempts to transform carbon nanotubes from biologically incompatible nanomaterials to biologically relevant components of advanced therapeutics and the ensuing novel structures obtained in our laboratories are presented.},
keywords = {Carbon nanotubes, gene delivery, gene therapy, I2CT, Nanomedicine, Peptide delivery, Team-Bianco, Vaccination},
pubstate = {published},
tppubtype = {article}
}
During the last few years, there has been a tremendous amount of optimism and expectation about nanotechnology and its impact on various fields including medicine and pharmaceutical development. One of the most promising materials being developed during the nanotechnological renaissance we are currently experiencing is the carbon nanotube. Before any biology-related application can even be envisaged, the aqueous solubility of carbon nanotubes has to be resolved. Recently, a variety of methodologies have been proposed which lead to biologically compatible carbon nanotubes. Covalent functionalization of their surface is one methodology, allowing the first attempts towards applications in the field of nanomedicine. The possibility of incorporating functionalized carbon nanotubes into cells and the biological milieu offers numerous advantages for potential applications in biology and pharmacology. One of the most promising is their utilization as a new carrier system for the delivery of therapeutic molecules. In the present article, the first attempts to transform carbon nanotubes from biologically incompatible nanomaterials to biologically relevant components of advanced therapeutics and the ensuing novel structures obtained in our laboratories are presented.
2004
Pantarotto Davide, Singh Ravi, McCarthy David, Erhardt Mathieu, Briand Jean-Paul, Prato Maurizio, Kostarelos Kostas, Bianco Alberto
Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery Article de journal
Dans: Angewandte Chemie International Edition, vol. 43, no. 39, p. 5242–5246, 2004, ISSN: 1521-3773.
Résumé | Liens | BibTeX | Étiquettes: Carbon nanotubes, gene delivery, I2CT, plasmid DNA, supramolecular chemistry, Team-Bianco
@article{pantarotto_functionalized_2004,
title = {Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery},
author = {Davide Pantarotto and Ravi Singh and David McCarthy and Mathieu Erhardt and Jean-Paul Briand and Maurizio Prato and Kostas Kostarelos and Alberto Bianco},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.200460437},
doi = {10.1002/anie.200460437},
issn = {1521-3773},
year = {2004},
date = {2004-01-01},
urldate = {2020-03-31},
journal = {Angewandte Chemie International Edition},
volume = {43},
number = {39},
pages = {5242--5246},
abstract = {Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.},
keywords = {Carbon nanotubes, gene delivery, I2CT, plasmid DNA, supramolecular chemistry, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.