@article{,
title = {Invasion of strongly binding oligonucleotides into tRNA structure},
author = {V Petyuk and R Serikov and V Tolstikov and V Potapov and R Giege and M Zenkova and V Vlassov},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10999254},
isbn = {10999254},
year = {2000},
date = {2000-01-01},
journal = {Nucleosides Nucleotides Nucleic Acids},
volume = {19},
number = {7},
pages = {1145-1158},
abstract = {Interaction of yeast tRNA(Phe) with oligodeoxyribonucleotides containing 5-methylcytosine, 2-aminoadenine, and 5-propynyl-2'-deoxyuridine was investigated. The modified oligonucleotides show increased binding capacity although the association rates are similar for the modified and natural oligonucleotides. The most pronounced increase in association constant (70 times) due to the incorporation of the strongly binding units was achieved in the case of oligonucleotide complementary to the sequence 65-76 of the tRNA(Phe).},
note = {1525-7770
Journal Article},
keywords = {2-Aminopurine/*analogs & derivatives/chemistry 5-Methylcytosine Cytosine/analogs & derivatives/chemistry Deoxyuridine/*analogs & derivatives/chemistry Electrophoresis, Non-U.S. Gov't Time Factors Yeasts/chemistry, Phe/*chemistry/metabolism Support, Polyacrylamide Gel Kinetics Nucleic Acid Conformation Oligodeoxyribonucleotides/chemistry Oligonucleotides/*metabolism RNA, Transfer, Unité ARN},
pubstate = {published},
tppubtype = {article}
}
Interaction of yeast tRNA(Phe) with oligodeoxyribonucleotides containing 5-methylcytosine, 2-aminoadenine, and 5-propynyl-2'-deoxyuridine was investigated. The modified oligonucleotides show increased binding capacity although the association rates are similar for the modified and natural oligonucleotides. The most pronounced increase in association constant (70 times) due to the incorporation of the strongly binding units was achieved in the case of oligonucleotide complementary to the sequence 65-76 of the tRNA(Phe).