M3i

@article{,

title = {Distinctive structures between chimpanzee and human in a brain noncoding RNA},

author = {A Beniaminov and E Westhof and A Krol},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18511501},

isbn = {18511501},

year  = {2008},

date = {2008-01-01},

journal = {RNA},

volume = {14},

number = {7},

pages = {1270-1275},

abstract = {Human accelerated region 1 (HAR1) is a short DNA region identified recently to have evolved the most rapidly among highly constrained regions since the divergence from our common ancestor with chimpanzee. It is transcribed as part of a noncoding RNA specifically expressed in the developing human neocortex. Employing a panoply of enzymatic and chemical probes, our analysis of HAR1 RNA proposed a secondary structure model differing from that published. Most surprisingly, we discovered that the substitutions between the chimpanzee and human sequences led the human HAR1 RNA to adopt a cloverleaf-like structure instead of an extended and unstable hairpin in the chimpanzee sequence. Thus, the rapid evolutionary changes resulted in a profound rearrangement of HAR1 RNA structure. Altogether, our results provide a structural context for elucidating HAR1 RNA function.},

note = {1469-9001 (Electronic) 

Letter 

Research Support, Non-U.S. Gov't},

keywords = {Animals Base Sequence Brain/*metabolism Evolution, Human  Humans  Molecular Sequence Data  Nucleic Acid Conformation  Pan troglodytes/*genetics  RNA, Molecular  Genome, Unité ARN, Untranslated/*chemistry, WESTHOF},

pubstate = {published},

tppubtype = {article}

}