Réponses antivirales chez le moustique Aedes

@article{,

title = {Two novel members of the LhrC family of small RNAs in Listeria monocytogenes with overlapping regulatory functions but distinctive expression profiles.},

author = {M Storm Mollerup and J A Ross and A C Helfer and K Meistrup and P Romby and B H Kallipolitis},

url = {http://www.ncbi.nlm.nih.gov/pubmed/27400116?dopt=Abstract},

doi = {10.1080/15476286.2016.1208332},

isbn = {27400116},

year  = {2016},

date = {2016-01-01},

journal = {RNA Biol},

volume = {13},

number = {9},

pages = {895-915},

abstract = {Multicopy small RNAs (sRNAs) have gained recognition as an important feature of bacterial gene regulation. In the human pathogen Listeria monocytogenes, five homologous sRNAs, called LhrC1-5, control gene expression by base pairing to target mRNAs though three conserved UCCC motifs common to all five LhrCs. We show here that the sRNAs Rli22 and Rli33-1 are structurally and functionally related to LhrC1-5, expanding the LhrC family to seven members, which makes it the largest multicopy sRNA family reported so far. Rli22 and Rli33-1 both contain two UCCC motifs important for post-transcriptional repression of three LhrC target genes. One such target, oppA, encodes a virulence-associated oligo-peptide binding protein. Like LhrC1-5, Rli22 and Rli33-1 employ their UCCC motifs to recognize the Shine-Dalgarno region of oppA mRNA and prevent formation of the ribosomal complex, demonstrating that the seven sRNAs act in a functionally redundant manner. However, differential expression profiles of the sRNAs under infection-relevant conditions suggest that they might also possess non-overlapping functions. Collectively, this makes the LhrC family a unique case for studying the purpose of sRNA multiplicity in the context of bacterial virulence.},

keywords = {Listeria monocytogenes antisense multiplicity post-transcriptional regulation sRNAs, ROMBY, Unité ARN},

pubstate = {published},

tppubtype = {article}

}