Réponses antivirales chez le moustique Aedes

@article{,

title = {The interaction networks of structured RNAs},

author = {A Lescoute and E Westhof},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17135184},

isbn = {17135184},

year  = {2006},

date = {2006-01-01},

journal = {Nucleic Acids Res},

volume = {34},

number = {22},

pages = {6587-6604},

abstract = {All pairwise interactions occurring between bases which could be detected in three-dimensional structures of crystallized RNA molecules are annotated on new planar diagrams. The diagrams attempt to map the underlying complex networks of base-base interactions and, especially, they aim at conveying key relationships between helical domains: co-axial stacking, bending and all Watson-Crick as well as non-Watson-Crick base pairs. Although such wiring diagrams cannot replace full stereographic images for correct spatial understanding and representation, they reveal structural similarities as well as the conserved patterns and distances between motifs which are present within the interaction networks of folded RNAs of similar or unrelated functions. Finally, the diagrams could help devising methods for meaningfully transforming RNA structures into graphs amenable to network analysis.},

note = {1362-4962 (Electronic) 

Journal Article 

Research Support, Non-U.S. Gov't},

keywords = {16S/chemistry  RNA, 23S/chemistry  Ribonuclease P/chemistry, Base Pairing Base Sequence Introns *Models, Catalytic/chemistry  RNA, Molecular  Molecular Sequence Data  Nucleic Acid Conformation  RNA/*chemistry  RNA, Ribosomal, Unité ARN, WESTHOF},

pubstate = {published},

tppubtype = {article}

}

@article{,

title = {Two conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site},

author = {J Kondo and A Urzhumtsev and E Westhof},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16452297},

isbn = {16452297},

year  = {2006},

date = {2006-01-01},

journal = {Nucleic Acids Res},

volume = {34},

number = {2},

pages = {676-685},

abstract = {The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.},

note = {1362-4962 (Electronic) 

Journal Article},

keywords = {16S/chemistry  RNA, 18S/*chemistry  Research Support, Animals Comparative Study Crystallography, Bacterial/chemistry  RNA, Molecular  Nebramycin/analogs & derivatives/chemistry  Nucleic Acid Conformation  RNA, Non-U.S. Gov't  Ribosomes/chemistry  Tetrahymena thermophila/genetics, Protozoan/chemistry  RNA, Ribosomal, Unité ARN, WESTHOF, X-Ray  Genetic Code  Humans  *Models},

pubstate = {published},

tppubtype = {article}

}