Réponses antivirales chez le moustique Aedes

@article{,

title = {Translating organellar glutamine codons: a case by case scenario?},

author = {M Frechin and A M Duchene and H D Becker},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19106621},

isbn = {19106621},

year  = {2009},

date = {2009-01-01},

journal = {RNA Biol},

volume = {6},

number = {1},

pages = {31-34},

abstract = {Aminoacyl-tRNAs are generally formed by direct attachment of an amino acid to tRNAs by aminoacyl-tRNA synthetases, but glutaminyl-tRNA (Q-tRNA) is an exception to this rule. Glutaminyl-tRNA(Gln) (Q-tRNA(Q)) is formed by this direct pathway in the eukaryotic cytosol and in a small subset of bacteria, but is formed by an indirect transamidation pathway in most bacteria and archaea. To date it is almost impossible to predict what pathway generates organellar Q-tRNA(Q) in a given eukaryote. All eukaryotic genomes sequenced so far, display a single glutaminyl-tRNA synthetase (QRS) gene which is at least responsible for the cytosolic QRS activity, as well as a gene coding for a mitochondrial ortholog of the essential GatB subunit of the tRNA-dependent amidotransferase (AdT). Indeed, QRS activity was found in protozoan mitochondria while AdT activity was characterized in plant organelles. The pathway for Q-tRNA(Q) synthesis in yeast and mammals mitochondria is still questionable.},

note = {1555-8584 (Electronic) 

Journal Article 

Research Support, Non-U.S. Gov't 

Review},

keywords = {Biological  Nitrogenous Group Transferases/metabolism  Plants/metabolism  RNA, KERN  Amino Acyl-tRNA Synthetases/metabolism  Animals  Chloroplasts/metabolism  Codon  Cytosol/metabolism  Glutamate-tRNA Ligase/metabolism  Glutamine/*chemistry  Mitochondria/metabolism  Models, Messenger/metabolism  RNA, Transfer/metabolism, Unité ARN},

pubstate = {published},

tppubtype = {article}

}