Publications
1989
Reichhart Jean-Marc, Essrich M, Dimarcq Jean-Luc, Hoffmann Danièle, Hoffmann Jules A, Lagueux Marie
Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization Article de journal
Dans: Eur. J. Biochem., vol. 182, no. 2, p. 423–427, 1989, ISSN: 0014-2956.
Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Bacterial Proteins, Base Sequence, Blotting, Diptera, DNA, Endoribonucleases, Enterobacter, Enterobacteriaceae, Gene Expression Regulation, Genes, Genetic, hoffmann, Insect Hormones, Insect Proteins, M3i, messenger, MHC Class II, Northern, reichhart, Ribonuclease H, RNA, Transcription
@article{reichhart_insect_1989,
title = {Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization},
author = {Jean-Marc Reichhart and M Essrich and Jean-Luc Dimarcq and Danièle Hoffmann and Jules A Hoffmann and Marie Lagueux},
issn = {0014-2956},
year = {1989},
date = {1989-01-01},
journal = {Eur. J. Biochem.},
volume = {182},
number = {2},
pages = {423--427},
abstract = {We have previously isolated and characterized a family of novel 8-kDa cationic antibacterial peptides synthesized by larvae of Phormia terranovae (Diptera) in response to various injuries. These molecules have been named diptericins. The peptide sequence of diptericin A was used to prepare oligonucleotides for screening cDNA libraries and we report in the present paper the isolation of several cDNA clones encoding diptericin. The analysis of the nucleotide sequences indicates that diptericin is synthesized as a prepeptide which is matured in two steps: (a) cleavage of a signal peptide and (b) amidation of the C-terminal residue. Interestingly, the 3' untranslated region of the mRNA contains a consensus sequence TTATTTAT which is also observed in the mRNA of another insect antibacterial peptide (attacin-related sarcotoxin IIA) and in mRNAs encoding proteins related to the inflammatory response in mammals. Our data illustrate that diptericins form a polymorphic family of immune peptides. The transcription of the diptericin genes is rapidly induced in the fat body after inoculation of bacteria, as evidenced by the transcriptional profile.},
keywords = {Animals, Anti-Bacterial Agents, Bacterial Proteins, Base Sequence, Blotting, Diptera, DNA, Endoribonucleases, Enterobacter, Enterobacteriaceae, Gene Expression Regulation, Genes, Genetic, hoffmann, Insect Hormones, Insect Proteins, M3i, messenger, MHC Class II, Northern, reichhart, Ribonuclease H, RNA, Transcription},
pubstate = {published},
tppubtype = {article}
}
Rosenthal G A, Reichhart Jean-Marc, Hoffmann Jules A
L-canavanine incorporation into vitellogenin and macromolecular conformation Article de journal
Dans: J. Biol. Chem., vol. 264, no. 23, p. 13693–13696, 1989, ISSN: 0021-9258.
Résumé | BibTeX | Étiquettes: Animals, Antibodies, Canavanine, fluorescence, Grasshoppers, hoffmann, M3i, Monoclonal, Protein Conformation, reichhart, Spectrometry, Vitellogenins
@article{rosenthal_l-canavanine_1989,
title = {L-canavanine incorporation into vitellogenin and macromolecular conformation},
author = {G A Rosenthal and Jean-Marc Reichhart and Jules A Hoffmann},
issn = {0021-9258},
year = {1989},
date = {1989-01-01},
journal = {J. Biol. Chem.},
volume = {264},
number = {23},
pages = {13693--13696},
abstract = {L-Canavanine is a potentially deleterious arginine antimetabolite whose toxicity is expressed in canavanine-sensitive organisms ranging from viruses to humans. Canavanine, a substrate for arginyl-tRNA synthetase, is incorporated into nascent polypeptide chains in place of arginine. This substitution results in the production of structurally aberrant, canavanyl proteins. Chemical, physical, and immunological studies of native and canavanine-containing vitellogenin obtained from female migratory locusts (Locusta migratoria migratorioides (Orthoptera] provide the first experimental evidence that canavanine can disrupt the tertiary and/or quaternary structure that yields the three-dimensional conformation unique to the protein. These findings enhance our understanding of the biochemical basis for canavanine's antimetabolic and potent insecticidal properties.},
keywords = {Animals, Antibodies, Canavanine, fluorescence, Grasshoppers, hoffmann, M3i, Monoclonal, Protein Conformation, reichhart, Spectrometry, Vitellogenins},
pubstate = {published},
tppubtype = {article}
}
1988
Holder F C, Lwoff L, Wicker C, Goltzené F, Meister Marie F, Zachary Daniel, Reichhart Jean-Marc
Production of monoclonal antibodies against corpora cardiaca extracts of Locusta migratoria : a potential tool for the isolation of insect neurohormones. Article de journal
Dans: Int. J. Invert. Reprod. Develop., vol. 14, p. 105–118, 1988.
Résumé | BibTeX | Étiquettes: M3i, reichhart
@article{holder_production_1988,
title = {Production of monoclonal antibodies against corpora cardiaca extracts of Locusta migratoria : a potential tool for the isolation of insect neurohormones.},
author = {F C Holder and L Lwoff and C Wicker and F Goltzené and Marie F Meister and Daniel Zachary and Jean-Marc Reichhart},
year = {1988},
date = {1988-01-01},
journal = {Int. J. Invert. Reprod. Develop.},
volume = {14},
pages = {105--118},
abstract = {Corpora cardiaca of Locusta migratoria contain the axon endings of the neurosecretory cells of the brain and store in neurosecretory granules a variety of mostly unidentified neurohormones. Homogenates of corpora cardiaca served to generate a battery of monoclonal antibodies screened by their immunoreactivity to antigenic determinants present in the neurosecretory cells of the pars intercerebralis in the brain. The results are illustrated with three selected monoclonal antibodies which recognize antigenes located within the neurosecretory granules of the pericarya of the pars intercerebralis, the cerebro-cardiac axon tracts and the axonic endings in the neurohaemal part of the corpora cardiaca. The apparent molecular weights of these antigenes were determined by Western blotting. We discuss the potential of these monoclonal antibodies for the isolation and structure determination of neuropeptides.},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
Dimarcq Jean-Luc, Keppi E, Dunbar B, Lambert J, Reichhart Jean-Marc, Hoffmann Danièle, Rankine S M, Fothergill J E, Hoffmann Jules A
Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A Article de journal
Dans: Eur. J. Biochem., vol. 171, no. 1-2, p. 17–22, 1988, ISSN: 0014-2956.
Résumé | BibTeX | Étiquettes: Amino Acids, Animals, Anti-Bacterial Agents, Diptera, Escherichia coli, hoffmann, Insect Hormones, Insect Proteins, Isoelectric Point, Larva, M3i, reichhart
@article{dimarcq_insect_1988,
title = {Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A},
author = {Jean-Luc Dimarcq and E Keppi and B Dunbar and J Lambert and Jean-Marc Reichhart and Danièle Hoffmann and S M Rankine and J E Fothergill and Jules A Hoffmann},
issn = {0014-2956},
year = {1988},
date = {1988-01-01},
journal = {Eur. J. Biochem.},
volume = {171},
number = {1-2},
pages = {17--22},
abstract = {Injury or injection of live bacteria into third instar larvae of the dipteran insect Phormia terranovae results in the appearance in the haemolymph of at least five groups of heat-stable, more or less basic peptides with antibacterial activity against Escherichia coli. Three of these peptides have been purified. The amino acid sequence has been completely established for one of these and partially (first 40 residues from the N-terminus) for the two others. The sequences show marked homologies indicating that the three peptides belong to a common family. They are not related to other known antibacterial peptides from insects [lysozymes, cecropins (including sarcotoxin I) and attacins]. We propose the name of diptericins for this new family of antibiotic molecules.},
keywords = {Amino Acids, Animals, Anti-Bacterial Agents, Diptera, Escherichia coli, hoffmann, Insect Hormones, Insect Proteins, Isoelectric Point, Larva, M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1987
Freund-Mercier M J, Stoekel M E, Palacios J M, Pazos A, Reichhart Jean-Marc, Porte A, Richard P
Pharmacological characteristics and anatomical distribution of (3H)oxytocin-binding sites in the wistar rat brain studied by autoradiography. Article de journal
Dans: Neuroscience, vol. 20, p. 599–614, 1987.
Résumé | BibTeX | Étiquettes: M3i, reichhart
@article{freund-mercier_pharmacological_1987,
title = {Pharmacological characteristics and anatomical distribution of (3H)oxytocin-binding sites in the wistar rat brain studied by autoradiography.},
author = {M J Freund-Mercier and M E Stoekel and J M Palacios and A Pazos and Jean-Marc Reichhart and A Porte and P Richard},
year = {1987},
date = {1987-01-01},
journal = {Neuroscience},
volume = {20},
pages = {599--614},
abstract = {Oxytocin-binding sites were detected by autoradiography on rat brain sections incubated in the presence of the [3H]oxytocin. These sites were characterized pharmacologically using quantitative autoradiography. High pressure liquid chromatography controls of the incubation media indicated that labelling was due to the intact [3H]oxytocin molecule. Pharmacological analysis of different locations (central amygdaloid nucleus, ventral subiculum and ventromedial hypothalamic nucleus) showed that the sites detected had a high affinity for oxytocin and also for arginine-vasopressin. In contrast, some areas known to bind vasopressin intensely, such as suprachiasmatic and lateral septum nuclei, had little or no affinity for oxytocin. Autoradiographs revealed [3H]oxytocin-binding sites in already known brain areas (olfactory centres, ventral subiculum, central amygdaloid nucleus, bed nucleus of the stria terminalis) albeit with more extensive labelling of some of these formations, in particular, the amygdaloid complex. In addition, specific [3H]oxytocin-binding sites were found in areas not yet reported to bind oxytocin, such as the paraventricular thalamic and caudate nuclei. In the hypothalamus, specific binding sites were not detected in the supraoptic and paraventricular nuclei : the only structure labelled was the ventrolateral part of the ventromedial nucleus. Discrepancies between the concentrations of [3H]oxytocin-binding sites, the known distribution of oxytocin-containing endings and electrophysiological data indicate that autoradiography, under our conditions, apparently only reveals some of the oxytocin receptors in the brain. Thus, in the hypothalamus, no relationship can be established between the known effect of oxytocin on oxytocinergic magnocellular neurons and detection of specific [3H]oxytocin-binding sites. Autoradiography may reveal mainly oxytocin-binding sites in areas receiving diverse "parasynaptic" information, where oxytocin might play a modulatory role rather than exerting rapid, short-term effects of the neurotransmitter type.},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1986
Reichhart Jean-Marc, Charlet Maurice
Ecdysiotropic activity in brains and corpora cardiaca of larvae and adults of Locusta migratoria : in vitro assays. Article de journal
Dans: Intern. J. of Invertebrate Reprod. and Develop., vol. 10, p. 17–25, 1986.
Résumé | BibTeX | Étiquettes: M3i, reichhart
@article{reichhart_ecdysiotropic_1986,
title = {Ecdysiotropic activity in brains and corpora cardiaca of larvae and adults of Locusta migratoria : in vitro assays.},
author = {Jean-Marc Reichhart and Maurice Charlet},
year = {1986},
date = {1986-01-01},
journal = {Intern. J. of Invertebrate Reprod. and Develop.},
volume = {10},
pages = {17--25},
abstract = {Under in vitro conditions the excised left and right prothoracic glands of a larva of Locusta migratoria produce similar amounts of ecdysone, as monitored by RIA. When brain-corpora cardiaca extracts from last instar larvae of the same species are added to one of the two glands, its ecdysone production is significantly increased over that of the homologous gland. The stimulation is dose dependant. This in vitro system has been used as an assay to probe the presence of ecdysiotropic factors in brain-corpora cardiaca complexes of larvae and adult females of Locusta migratoria. The results show that the apparent titres of ecdysiotropic factors in these extracts fluctuated during larval development and in adult females. These fluctuations are discussed in relation to our present information on the role of brain and corpora cardiaca in the control of ecdysone synthesis in prothoracic glands and follicle cell epithelia in this species.},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
Keppi E, Dimarcq Jean-Luc, Lambert J, Zachary Daniel, Reichhart Jean-Marc, Hoffmann Danièle, Keller R, Hoffmann Jules A
Recherches sur les mécanismes de défense antibactérienne chez les Insectes : isolement de peptides antibactériens dans l'hémolymphe du Diptère Phormia terranovae. Article de journal
Dans: 303, p. 155–160, 1986.
Résumé | BibTeX | Étiquettes: hoffmann, M3i, reichhart
@article{keppi_recherches_1986,
title = {Recherches sur les mécanismes de défense antibactérienne chez les Insectes : isolement de peptides antibactériens dans l'hémolymphe du Diptère Phormia terranovae.},
author = {E Keppi and Jean-Luc Dimarcq and J Lambert and Daniel Zachary and Jean-Marc Reichhart and Danièle Hoffmann and R Keller and Jules A Hoffmann},
year = {1986},
date = {1986-01-01},
journal = {303},
pages = {155--160},
address = {Paris},
edition = {C. R. Acad. Sc.},
abstract = {Three groups of antibacterial peptides were isolated from immune hemolymph of larvae of the Dipteran Phormia terranovae through a combination of heat-treatment, cation exchange chromatography, gel permeation chromatography and HPLC. Their amino-acid composition was determined and showed marked analogies between the various peptides. They differed in several respects from known antibacterial peptides such as cecropins and attacins of Lepidopterans and from Sarcotoxin I from the Dipteran Sarcophaga peregrina.},
keywords = {hoffmann, M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1985
Grau Y, Reichhart Jean-Marc, Thiebold J
Growth stimulation of the immature chick oviduct by androgens : the vagina as a new target tissue. Article de journal
Dans: vol. 85, p. 1–13, 1985.
Résumé | BibTeX | Étiquettes: M3i, reichhart
@article{grau_growth_1985,
title = {Growth stimulation of the immature chick oviduct by androgens : the vagina as a new target tissue.},
author = {Y Grau and Jean-Marc Reichhart and J Thiebold},
year = {1985},
date = {1985-01-01},
volume = {85},
pages = {1--13},
abstract = {Testosterone when injected alone stimulates growth of the vagina but is inactive upon the other segments of the oviduct of the immature chicken. This action of testosterone can already be detected in embryos : it is expressed by the beginning of differenciation of the vaginal mesenchyme cells into smooth muscle cells. In the treated immature chicken, stimulation of growth is considerable and is specifically caused by androgens (testosterone and 5-a-dihydrotestosterone); the vaginal mesenchyme differentiates into ciliated cells and goblets cells. (3H) testosterone binding has been found in the vagina of the immature chicken (data not shown). The characteristics of testosterone binding to cytoplasmic components of the chick vagina are consistent with its identity as a testosterone receptor.},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1981
Thiebold J, Petit A, Reichhart Jean-Marc
The asymetric development of the gonads in the female chick embryo : new experimental data and retrospect. Book Section
Dans: Development and function of reproductive organs, p. 244–249, Byskov & Peters, excerpta Medica, Amsterdam-Oxford-Princeton, 1981.
BibTeX | Étiquettes: M3i, reichhart
@incollection{thiebold_asymetric_1981,
title = {The asymetric development of the gonads in the female chick embryo : new experimental data and retrospect.},
author = {J Thiebold and A Petit and Jean-Marc Reichhart},
year = {1981},
date = {1981-01-01},
booktitle = {Development and function of reproductive organs},
pages = {244--249},
publisher = {Byskov & Peters, excerpta Medica, Amsterdam-Oxford-Princeton},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {incollection}
}
1980
Reichhart Jean-Marc, Weniger J P, Thiebold J
Responsiveness of developing chick müllerian ducts to sex steroids. Article de journal
Dans: Gen.Comp.Endocrin., vol. 40, p. 328, 1980.
BibTeX | Étiquettes: M3i, reichhart
@article{reichhart_responsiveness_1980,
title = {Responsiveness of developing chick müllerian ducts to sex steroids.},
author = {Jean-Marc Reichhart and J P Weniger and J Thiebold},
year = {1980},
date = {1980-01-01},
journal = {Gen.Comp.Endocrin.},
volume = {40},
pages = {328},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1977
Reichhart Jean-Marc, Thiebold J
Nouvelles données sur la croissance asymétrique du tractus müllérien chez l'embryon de Poulet femelle. Article de journal
Dans: C. R. Soc. Biol., vol. 171, p. 1097–1100, 1977.
Résumé | BibTeX | Étiquettes: M3i, reichhart
@article{reichhart_nouvelles_1977,
title = {Nouvelles données sur la croissance asymétrique du tractus müllérien chez l'embryon de Poulet femelle.},
author = {Jean-Marc Reichhart and J Thiebold},
year = {1977},
date = {1977-01-01},
journal = {C. R. Soc. Biol.},
volume = {171},
pages = {1097--1100},
abstract = {Shape and orientation of the mesothelial cells were examined in the mullerian ducts of 8, 13 and 15 day female chick embryos with the scanning eletron microscope. The observed evolution in the pattern of these cells likely reflects the mechanical conditions to which these organs are subjected during embryonic development : stretching for the left duct, slackening for the right duct. These observations, together with data concerning growth of these organs suggest that topographical relationships between cells, which in this system result from mechanical factors, play an important role in controlling cell proliferation.},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1976
Thiebold J, Reichhart Jean-Marc
Ontogenèse de la sensibilité des canaux de Müller à l'oestradiol chez le Poulet. Article de journal
Dans: Bull. Soc. Zool. France, vol. 101, p. 115–119, 1976.
BibTeX | Étiquettes: M3i, reichhart
@article{thiebold_ontogenese_1976,
title = {Ontogenèse de la sensibilité des canaux de Müller à l'oestradiol chez le Poulet.},
author = {J Thiebold and Jean-Marc Reichhart},
year = {1976},
date = {1976-01-01},
journal = {Bull. Soc. Zool. France},
volume = {101},
pages = {115--119},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
Thiebold J, Reichhart Jean-Marc
Prolifération cellulaire et différenciation des canaux de Müller chez l'embryon de Poulet femelle. Article de journal
Dans: Bull. Soc. Zool. France, vol. 101, p. 107–111, 1976.
Résumé | BibTeX | Étiquettes: M3i, reichhart
@article{thiebold_proliferation_1976,
title = {Prolifération cellulaire et différenciation des canaux de Müller chez l'embryon de Poulet femelle.},
author = {J Thiebold and Jean-Marc Reichhart},
year = {1976},
date = {1976-01-01},
journal = {Bull. Soc. Zool. France},
volume = {101},
pages = {107--111},
abstract = {A hypothesis is put forward according to which mullerian asymmetry in birds (functional left oviduct, rudimentary right mullerian duct) results from different mechanic conditions for the right and left ducts during embryonic life. The slowing down of growth in the right duct could be correlative to a loss of sensitivity to the ovarian hormone.},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}
1973
Thiebold J, Reichhart Jean-Marc
Inhibition du développement ovarien par la greffe de gonades embryonnaires chez le Poulet. Article de journal
Dans: C. R. Soc. Zool. France, vol. 167, p. 1958–1960, 1973.
BibTeX | Étiquettes: M3i, reichhart
@article{thiebold_inhibition_1973,
title = {Inhibition du développement ovarien par la greffe de gonades embryonnaires chez le Poulet.},
author = {J Thiebold and Jean-Marc Reichhart},
year = {1973},
date = {1973-01-01},
journal = {C. R. Soc. Zool. France},
volume = {167},
pages = {1958--1960},
keywords = {M3i, reichhart},
pubstate = {published},
tppubtype = {article}
}