@article{zacchigna_vitro_2009,
title = {In vitro behavior of multifunctionalized fullerene-warfarin conjugates},
author = {Marina Zacchigna and Cedric Klumpp and Maurizio Prato and Alberto Bianco},
doi = {10.1166/jnn.2009.1551},
issn = {1533-4880},
year = {2009},
date = {2009-10-01},
journal = {Journal of Nanoscience and Nanotechnology},
volume = {9},
number = {10},
pages = {6210--6221},
abstract = {In this study we have covalently linked the anticoagulant warfarin to polyfunctionalized fullerenes. The objective was to explore the possibility of modifying the biological profile of a drug by covalent binding to functionalized fullerene. We have chosen warfarin as a model compound because it a widely used drug. We have analyzed the stability in vitro of the conjugates and found that the drug is released from the carbon support only after incubation in mouse plasma.},
keywords = {Animals, Anticoagulants, Fullerenes, I2CT, In Vitro Techniques, Mice, Spectrophotometry, Team-Bianco, Ultraviolet, Warfarin},
pubstate = {published},
tppubtype = {article}
}
In this study we have covalently linked the anticoagulant warfarin to polyfunctionalized fullerenes. The objective was to explore the possibility of modifying the biological profile of a drug by covalent binding to functionalized fullerene. We have chosen warfarin as a model compound because it a widely used drug. We have analyzed the stability in vitro of the conjugates and found that the drug is released from the carbon support only after incubation in mouse plasma.