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2018

Sawaf Matthieu, Fauny Jean-Daniel, Felten Renaud, Sagez Flora, Gottenberg Jacques-Eric, Dumortier Hélène, Monneaux Fanny

Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ Ŧ cells Article de journal

Dans: JCI insight, 3 (13), 2018, ISSN: 2379-3708.

Résumé | Liens | BibTeX | Étiquettes: 80 and over, Adolescent, Adult, Aged, Autoimmune Diseases, Autoimmunity, CD4-Positive T-Lymphocytes, Cell Proliferation, CTLA-4 Antigen, Dumortier, Female, France, Humans, I2CT, Imagerie, Immunologic, Immunology, Lipid Metabolism, lupus, Lupus Erythematosus, Lymphocyte Activation, Male, Middle Aged, Monneaux, Programmed Cell Death 1 Receptor, Receptors, Signal Transduction, Systemic, Team-Dumortier, Young Adult

2016

Sawaf Matthieu, Dumortier Hélène, Monneaux Fanny

Follicular Helper Ŧ Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? Article de journal

Dans: Journal of Immunology Research, 2016 , p. 5767106, 2016, ISSN: 2314-7156.

Résumé | Liens | BibTeX | Étiquettes: Adult, Autoantibodies, B-Lymphocytes, Cell Differentiation, Dumortier, Germinal Center, Helper-Inducer, Humans, I2CT, Lupus Erythematosus, Molecular Targeted Therapy, Monneaux, Plasma Cells, Systemic, T-Lymphocytes, Team-Dumortier

2013

Coz Carole Le, Joublin Aurélie, Pasquali Jean-Louis, Korganow Anne-Sophie, Dumortier Hélène, Monneaux Fanny

Circulating TFH subset distribution is strongly affected in lupus patients with an active disease Article de journal

Dans: PloS One, 8 (9), p. e75319, 2013, ISSN: 1932-6203.

Résumé | Liens | BibTeX | Étiquettes: Adult, Aged, B-Lymphocytes, Case-Control Studies, CD4 Lymphocyte Count, CD5 Antigens, CXCR5, Cytokines, Dumortier, Female, Flow Cytometry, Helper-Inducer, Humans, I2CT, Immunoglobulin E, Immunologic Memory, Immunophenotyping, Interleukin-21, Lupus Erythematosus, Male, Middle Aged, Monneaux, Phenotype, Receptors, Systemic, T-Lymphocytes, Team-Dumortier, Th2 Cells, Young Adult

2012

Thomann Jean-Sébastien, Monneaux Fanny, Creusat Gaëlle, Spanedda Maria Vittoria, Heurtault Béatrice, Habermacher Chloé, Schuber Francis, Bourel-Bonnet Line, Frisch Benoît

Novel glycolipid TLR2 ligands of the type Pam2Cys-α-Gal: synthesis and biological properties Article de journal

Dans: European Journal of Medicinal Chemistry, 51 , p. 174–183, 2012, ISSN: 1768-3254.

Résumé | Liens | BibTeX | Étiquettes: Adjuvants, Animals, Cell Line, Chemistry Techniques, Female, Galactose, Glycolipids, Humans, I2CT, Immunologic, ligands, Mice, Monneaux, Structure-Activity Relationship, Synthetic, Team-Dumortier, Toll-Like Receptor 2

Keravis Thérèse, Monneaux Fanny, Yougbaré Issaka, Gazi Lucien, Bourguignon Jean-Jacques, Muller Sylviane, Lugnier Claire

Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor Article de journal

Dans: PloS One, 7 (1), p. e28899, 2012, ISSN: 1932-6203.

Résumé | Liens | BibTeX | Étiquettes: Adenine, Animals, Cyclic AMP, Cyclic Nucleotide Phosphodiesterases, Disease Progression, Female, Humans, I2CT, Inbred CBA, Inbred MRL lpr, Isoenzymes, Kidney, Lipopolysaccharides, Lupus Erythematosus, Mice, Monneaux, Pentoxifylline, Phosphodiesterase 4 Inhibitors, Proteinuria, Survival Rate, Systemic, Team-Dumortier, Tumor Necrosis Factor-alpha, Type 4, Xanthines

2011

Banchet-Cadeddu Aline, Martinez Agathe, Guillarme Stéphane, Parietti Véronique, Monneaux Fanny, Hénon Eric, Renault Jean-Hugues, Nuzillard Jean-Marc, Haudrechy Arnaud

Use of the NEO strategy (Nucleophilic addition/Epoxide Opening) for the synthesis of a new C-galactoside ester analogue of KRN 7000 Article de journal

Dans: Bioorganic & Medicinal Chemistry Letters, 21 (8), p. 2510–2514, 2011, ISSN: 1464-3405.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Proliferation, Cells, Cultured, Esters, Galactosides, Galactosylceramides, Glycolipids, I2CT, Interferon-gamma, Interleukin-4, Mice, Monneaux, Team-Dumortier

Banchet-Cadeddu Aline, Hénon Eric, Dauchez Manuel, Renault Jean-Hugues, Monneaux Fanny, Haudrechy Arnaud

The stimulating adventure of KRN 7000 Article de journal

Dans: Organic & Biomolecular Chemistry, 9 (9), p. 3080–3104, 2011, ISSN: 1477-0539.

Résumé | Liens | BibTeX | Étiquettes: Adjuvants, Animals, Antigen, Antigens, CD1d, Galactosylceramides, Helper-Inducer, Humans, I2CT, Immunologic, Monneaux, Receptors, T-Cell, T-Lymphocytes, Team-Dumortier

2010

Parietti Véronique, Chifflot Hélène, Sibilia Jean, Muller Sylviane, Monneaux Fanny

Rituximab treatment overcomes reduction of regulatory iNKT cells in patients with rheumatoid arthritis Article de journal

Dans: Clinical Immunology (Orlando, Fla.), 134 (3), p. 331–339, 2010, ISSN: 1521-7035.

Résumé | Liens | BibTeX | Étiquettes: Adult, Age Factors, Aged, Antibodies, Antirheumatic Agents, arthritis, Female, Flow Cytometry, Humans, I2CT, Longitudinal Studies, Male, Middle Aged, Monneaux, Monoclonal, Murine-Derived, Natural Killer T-Cells, Nonparametric, rheumatoid, Rituximab, Sex Factors, Statistics, Team-Dumortier, Young Adult

2009

Chamouard Patrick, Monneaux Fanny, Richert Zoe, Voegeli Anne-Claire, Lavaux Thomas, Gaub Marie Pierre, Baumann René, Oudet Pierre, Muller Sylviane

Diminution of Circulating CD4+CD25 high Ŧ cells in naïve Crohn's disease Article de journal

Dans: Digestive Diseases and Sciences, 54 (10), p. 2084–2093, 2009, ISSN: 1573-2568.

Résumé | Liens | BibTeX | Étiquettes: Adult, Aged, Blood Cell Count, CD4 Antigens, Colitis, Crohn Disease, Female, Flow Cytometry, Humans, I2CT, Interleukin-2 Receptor alpha Subunit, Lymphocyte Subsets, Male, Middle Aged, Monneaux, Regulatory, T-Lymphocytes, Team-Dumortier, Ulcerative

Monneaux Fanny, Muller Sylviane

Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects Article de journal

Dans: Arthritis Research & Therapy, 11 (3), p. 234, 2009, ISSN: 1478-6362.

Résumé | Liens | BibTeX | Étiquettes: Animals, Clinical Trials as Topic, Forecasting, Genetic Therapy, Humans, I2CT, Lupus Erythematosus, Monneaux, Systemic, Team-Dumortier

2008

Parietti Véronique, Monneaux Fanny, Décossas Marion, Muller Sylviane

Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector Ŧ cells Article de journal

Dans: Arthritis and Rheumatism, 58 (6), p. 1751–1761, 2008, ISSN: 0004-3591.

Résumé | Liens | BibTeX | Étiquettes: Animal, Animals, Antigen-Presenting Cells, Antigens, B7-1 Antigen, B7-2 Antigen, CD, Cell Communication, Cells, Coculture Techniques, CTLA-4 Antigen, Cultured, Disease Models, Female, I2CT, Interleukin-1, Interleukin-2 Receptor alpha Subunit, Lupus Erythematosus, Mice, Monneaux, Regulatory, Systemic, T-Lymphocyte Subsets, T-Lymphocytes, Team-Dumortier

Muller Sylviane, Monneaux Fanny, Schall Nicolas, Rashkov Rasho K, Oparanov Boycho A, Wiesel Philippe, Geiger Jean-Marie, Zimmer Robert

Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: results of an early phase II clinical trial Article de journal

Dans: Arthritis and Rheumatism, 58 (12), p. 3873–3883, 2008, ISSN: 0004-3591.

Résumé | Liens | BibTeX | Étiquettes: Adolescent, Adult, Aged, Antibodies, Antinuclear, C-Reactive Protein, DNA, Female, Humans, I2CT, Immunotherapy, Lupus Erythematosus, Male, Middle Aged, Monneaux, Peptide Fragments, Peptides, Severity of Illness Index, Spliceosomes, Systemic, Team-Dumortier, Treatment Outcome, Young Adult

Dieker J, Cisterna B, Monneaux F, Decossas M, van der Vlag J, Biggiogera M, Muller S

Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K Article de journal

Dans: Cell Death and Differentiation, 15 (4), p. 793–804, 2008, ISSN: 1350-9047.

Résumé | Liens | BibTeX | Étiquettes: Apoptosis, Autoantigens, Autoimmunity, Caspase 3, Chromatin, HeLa Cells, Humans, I2CT, Jurkat Cells, Lupus Erythematosus, Monneaux, Phosphorylation, Post-Translational, Protein Phosphatase 1, Protein Processing, Protein Transport, Recombinant Proteins, Ribonucleoprotein, RNA Splicing, Serine, Spliceosomes, Systemic, Team-Dumortier, Time Factors, U1 Small Nuclear

2007

Monneaux Fanny, Muller Sylviane

Peptide-based therapy in lupus: promising data Article de journal

Dans: Advances in Experimental Medicine and Biology, 601 , p. 105–112, 2007, ISSN: 0065-2598.

Résumé | Liens | BibTeX | Étiquettes: Adrenal Cortex Hormones, Animals, Autoantigens, Autoimmune Diseases, Cyclophosphamide, Epitopes, Humans, I2CT, Immune System, Immunosuppressive Agents, inflammation, Lupus Erythematosus, Monneaux, Peptides, Systemic, T-Lymphocytes, Team-Dumortier

Parietti Véronique, Chifflot Hélène, Muller Sylviane, Monneaux Fanny

Regulatory Ŧ cells and systemic lupus erythematosus Article de journal

Dans: Annals of the New York Academy of Sciences, 1108 , p. 64–75, 2007, ISSN: 0077-8923.

Résumé | Liens | BibTeX | Étiquettes: Animals, Autoimmunity, Humans, I2CT, Immune Tolerance, Lupus Erythematosus, Monneaux, Regulatory, Systemic, T-Lymphocyte Subsets, T-Lymphocytes, Team-Dumortier

Monneaux F, Muller S

[The spliceosome and its interest for lupus therapy] Article de journal

Dans: La Revue De Medecine Interne, 28 (10), p. 725–728, 2007, ISSN: 0248-8663.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid Motifs, Animals, Antibodies, CD4-Positive T-Lymphocytes, Conserved Sequence, DNA, Epitopes, Haplotypes, Humans, I2CT, Immune Tolerance, Inbred MRL lpr, Inbred NZB, Lupus Erythematosus, Mice, Monneaux, Phosphoserine, Protein, Recombinant, Ribonucleoprotein, Sequence Analysis, Serine, Spliceosomes, Systemic, Team-Dumortier, U1 Small Nuclear

Woods Anne, Monneaux Fanny, Soulas-Sprauel Pauline, Muller Sylviane, Martin Thierry, Korganow Anne-Sophie, Pasquali Jean-Louis

Influenza virus-induced type I interferon leads to polyclonal B-cell activation but does not break down B-cell tolerance Article de journal

Dans: Journal of Virology, 81 (22), p. 12525–12534, 2007, ISSN: 0022-538X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antibody Formation, Autoantibodies, Autoantigens, Autoimmunity, B-Lymphocytes, Humans, I2CT, Immune Tolerance, Immunoglobulin M, Inbred Strains, Influenza A virus, Interferon Type I, Lymphocyte Activation, Mice, Monneaux, Rheumatoid Factor, Team-Dumortier, transgenic

Monneaux Fanny, Parietti Véronique, Briand Jean-Paul, Muller Sylviane

Importance of spliceosomal RNP1 motif for intermolecular Ŧ-B cell spreading and tolerance restoration in lupus Article de journal

Dans: Arthritis Research & Therapy, 9 (5), p. R111, 2007, ISSN: 1478-6362.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid Motifs, Amino Acid Sequence, Animals, B-Lymphocytes, I2CT, Immune Tolerance, Inbred MRL lpr, Lupus Erythematosus, Mice, Molecular Sequence Data, Monneaux, Ribonucleoproteins, RNA-Binding Proteins, Saccharomyces cerevisiae Proteins, Spliceosomes, Systemic, T-Lymphocytes, Team-Dumortier

2005

Monneaux Fanny, Hoebeke Johan, Sordet Christelle, Nonn Céline, Briand Jean-Paul, Maillère Bernard, Sibilia Jean, Muller Sylviane

Selective modulation of CD4+ Ŧ cells from lupus patients by a promiscuous, protective peptide analog Article de journal

Dans: Journal of Immunology (Baltimore, Md.: 1950), 175 (9), p. 5839–5847, 2005, ISSN: 0022-1767.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid Sequence, CD4-Positive T-Lymphocytes, HLA-DR Antigens, Humans, I2CT, Interleukin-10, Lupus Erythematosus, Lymphocyte Activation, Molecular Sequence Data, Monneaux, Peptide Fragments, Phosphorylation, Ribonucleoprotein, Systemic, Team-Dumortier, U1 Small Nuclear

2004

Monneaux Fanny, Parietti Véronique, Briand Jean-Paul, Muller Sylviane

Intramolecular Ŧ cell spreading in unprimed MRL/lpr mice: importance of the U1-70k protein sequence 131-151 Article de journal

Dans: Arthritis and Rheumatism, 50 (10), p. 3232–3238, 2004, ISSN: 0004-3591.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Division, Female, I2CT, Immunization, Inbred BALB C, Inbred MRL lpr, Lupus Erythematosus, Lymphocytes, Mice, Monneaux, Peptides, Phosphorylation, Ribonucleoprotein, Systemic, Team-Dumortier, U1 Small Nuclear

Monneaux Fanny, Muller Sylviane

Peptide-based immunotherapy of systemic lupus erythematosus Article de journal

Dans: Autoimmunity Reviews, 3 (1), p. 16–24, 2004, ISSN: 1568-9972.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antibodies, Antinuclear, Epitopes, Humans, I2CT, Immunotherapy, Lupus Erythematosus, Mice, Monneaux, Peptides, Systemic, T-Lymphocytes, Team-Dumortier

2003

Monneaux Fanny, Lozano José Manuel, Patarroyo Manuel E, Briand Jean-Paul, Muller Sylviane

T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice Article de journal

Dans: European Journal of Immunology, 33 (2), p. 287–296, 2003, ISSN: 0014-2980.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid Sequence, Animal, Animals, Autoantibodies, Autoantigens, Autoimmune Diseases, B-Lymphocytes, Cross Reactions, Disease Models, Female, HLA-DR Antigens, HLA-DR Serological Subtypes, HLA-DR1 Antigen, HLA-DR4 Antigen, Humans, I2CT, Immunization, Immunotherapy, Inbred BALB C, Inbred MRL lpr, Lupus Erythematosus, Lupus Nephritis, Mice, Molecular Sequence Data, Monneaux, Peptide Fragments, Phosphorylation, Protein Binding, Ribonucleoprotein, Systemic, T-Lymphocytes, Team-Dumortier, U1 Small Nuclear

2002

Monneaux Fanny, Muller Sylviane

Epitope spreading in systemic lupus erythematosus: identification of triggering peptide sequences Article de journal

Dans: Arthritis and Rheumatism, 46 (6), p. 1430–1438, 2002, ISSN: 0004-3591.

Liens | BibTeX | Étiquettes: Amino Acid Sequence, Animals, B-Lymphocyte, Epitopes, Humans, I2CT, Lupus Erythematosus, Molecular Sequence Data, Monneaux, Systemic, T-Lymphocyte, Team-Dumortier

2001

Monneaux F, Muller S

Key sequences involved in the spreading of the systemic autoimmune response to spliceosomal proteins Article de journal

Dans: Scandinavian Journal of Immunology, 54 (1-2), p. 45–54, 2001, ISSN: 0300-9475.

Résumé | Liens | BibTeX | Étiquettes: Animals, Autoantibodies, Autoimmune Diseases, Autoimmunity, B-Lymphocyte, Epitopes, Humans, I2CT, Mice, Monneaux, Ribonucleoproteins, Spliceosomes, Team-Dumortier

Monneaux F, Dumortier H, Steiner G, Briand J P, Muller S

Murine models of systemic lupus erythematosus: B and Ŧ cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB x NZW)F(1) lupus mice Article de journal

Dans: International Immunology, 13 (9), p. 1155–1163, 2001, ISSN: 0953-8178.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antibody Specificity, B-Lymphocytes, Crosses, Dumortier, fas Receptor, Female, Genetic, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, Heterogeneous-Nuclear Ribonucleoproteins, Histocompatibility Antigens Class II, I2CT, Immunoglobulin G, Inbred MRL lpr, Inbred NZB, Lupus Erythematosus, Mice, Monneaux, Peptide Fragments, Ribonucleoprotein, Ribonucleoproteins, Small Nuclear, Species Specificity, Spliceosomes, Systemic, T-Lymphocytes, Team-Dumortier, U1 Small Nuclear

2000

Monneaux F, Muller S

Laboratory protocols for the identification of Th cell epitopes on self-antigens in mice with systemic autoimmune diseases Article de journal

Dans: Journal of Immunological Methods, 244 (1-2), p. 195–204, 2000, ISSN: 0022-1759.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antigen Presentation, Antigen-Presenting Cells, Autoantigens, B-Lymphocytes, Coculture Techniques, Epitopes, Female, Flow Cytometry, I2CT, Inbred MRL lpr, Inbred NZB, Lupus Erythematosus, Lymphocyte Activation, Mice, Monneaux, Ribonucleoproteins, Small Nuclear, Systemic, T-Lymphocyte, Team-Dumortier, Th1 Cells, Th2 Cells

Dumortier H, Monneaux F, Jahn-Schmid B, Briand J P, Skriner K, Cohen P L, Smolen J S, Steiner G, Muller S

B and Ŧ cell responses to the spliceosomal heterogeneous nuclear ribonucleoproteins A2 and B1 in normal and lupus mice Article de journal

Dans: Journal of Immunology (Baltimore, Md.: 1950), 165 (4), p. 2297–2305, 2000, ISSN: 0022-1767.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid Sequence, Animals, Autoantibodies, B-Lymphocytes, Dumortier, Epitope Mapping, Female, Heterogeneous Nuclear, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, Heterogeneous-Nuclear Ribonucleoproteins, Humans, I2CT, Immunoglobulin G, Inbred BALB C, Inbred C57BL, Inbred CBA, Inbred MRL lpr, Injections, Lupus Nephritis, Lymphocyte Activation, Male, Mice, Molecular Sequence Data, Monneaux, Peptide Fragments, Recombinant Proteins, Ribonucleoproteins, RNA, Spliceosomes, Subcutaneous, T-Lymphocytes, Team-Dumortier, transgenic

Monneaux F, Briand J P, Muller S

B and Ŧ cell immune response to small nuclear ribonucleoprotein particles in lupus mice: autoreactive CD4(+) Ŧ cells recognize a Ŧ cell epitope located within the RNP80 motif of the 70K protein Article de journal

Dans: European Journal of Immunology, 30 (8), p. 2191–2200, 2000, ISSN: 0014-2980.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid Motifs, Animals, Antigen-Presenting Cells, Autoimmunity, B-Lymphocytes, CD4-Positive T-Lymphocytes, Epitopes, Female, I2CT, Inbred BALB C, Inbred CBA, Inbred MRL lpr, Lupus Vulgaris, Lymphocyte Activation, Mice, Monneaux, Peptide Fragments, Ribonucleoprotein, T-Lymphocyte, Team-Dumortier, U1 Small Nuclear