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2011

Reichhart Jean-Marc, Gubb David, Leclerc Vincent

The Drosophila serpins: multiple functions in immunity and morphogenesis Article de journal

Dans: Meth. Enzymol., 499 , p. 205–225, 2011, ISSN: 1557-7988.

Résumé | Liens | BibTeX | Étiquettes: Animals, Immunity, Innate, M3i, Morphogenesis, reichhart, Serpins, Signal Transduction

2010

Silverman Gary A, Whisstock James C, Bottomley Stephen P, Huntington James A, Kaiserman Dion, Luke Cliff J, Pak Stephen C, Reichhart Jean-Marc, Bird Phillip I

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems Article de journal

Dans: J. Biol. Chem., 285 (32), p. 24299–24305, 2010, ISSN: 1083-351X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological, Caenorhabditis elegans, Cell Death, Cell Differentiation, Cell Survival, Homeostasis, Humans, Immunity, Innate, M3i, Mice, Models, Phenotype, reichhart, Serpins, Transgenes, transgenic

Whisstock James C, Silverman Gary A, Bird Phillip I, Bottomley Stephen P, Kaiserman Dion, Luke Cliff J, Pak Stephen C, Reichhart Jean-Marc, Huntington James A

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions Article de journal

Dans: J. Biol. Chem., 285 (32), p. 24307–24312, 2010, ISSN: 1083-351X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological, Biological Transport, Biophysics, Catalytic Domain, Hormones, Humans, Kinetics, M3i, Models, Peptide Hydrolases, Protein Binding, Protein Conformation, Protein Structure, reichhart, Serpins, Substrate Specificity, Tertiary, Thrombin

Matskevich Alexey A, Quintin Jessica, Ferrandon Dominique

The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function Article de journal

Dans: Eur. J. Immunol., 40 (5), p. 1244–1254, 2010, ISSN: 1521-4141.

Résumé | Liens | BibTeX | Étiquettes: Agglutination, Animals, Beauveria, Beauveria/immunology, Candida albicans, Candida albicans/immunology, Carrier Proteins, Carrier Proteins/*immunology/pharmacology, Drosophila melanogaster/*immunology/microbiology, Drosophila Proteins/*immunology/pharmacology/physiology, Enzyme Activation, ferrandon, Fungal, Fungi, Fungi/*immunology, Hemolymph, Hemolymph/immunology, M3i, Melanins, Melanins/*physiology, Monophenol Monooxygenase, Monophenol Monooxygenase/physiology, Multiprotein Complexes, Multiprotein Complexes/physiology, Recombinant Fusion Proteins, Recombinant Fusion Proteins/pharmacology, Serpins, Serpins/physiology, Spores, Toll-Like Receptors, Toll-Like Receptors/immunology

2009

Garrett Matthew, Fullaondo Ane, Troxler Laurent, Micklem Gos, Gubb David

Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes Article de journal

Dans: BMC Genomics, 10 , p. 489, 2009, ISSN: 1471-2164.

Résumé | Liens | BibTeX | Étiquettes: Animals, bioinformatic, Comparative Genomic Hybridization, Conserved Sequence, DNA, Drosophilidae, Evolution, Genome, Insect, Molecular, Multigene Family, Sequence Alignment, Sequence Analysis, Serpins, Synteny

2007

Gubb David, Robertson Andrew S, Troxler Laurent, Reichhart Jean-Marc

Drosophila Serpins: Regulatory Cascades in Innate Immunity and Morphogenesis Recueil

Dans: Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, p. 207–227, Silverman GA and Lomas DA, London UK, 2007.

BibTeX | Étiquettes: bioinformatic, innate immunity, M3i, Morphogenesis, regulatory Cascades, reichhart, Serpins

2006

Pelte Nadège, Robertson Andrew S, Zou Zhen, Belorgey Didier, Dafforn Timothy R, Jiang Haobo, Lomas David, Reichhart Jean-Marc, Gubb David

Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic Article de journal

Dans: Insect Biochem. Mol. Biol., 36 (1), p. 37–46, 2006, ISSN: 0965-1748.

Résumé | Liens | BibTeX | Étiquettes: Animals, Gene Expression Regulation, M3i, Protein Conformation, reichhart, Serpins, Signal Transduction

2005

Reichhart Jean-Marc

Tip of another iceberg: Drosophila serpins Article de journal

Dans: Trends Cell Biol., 15 (12), p. 659–665, 2005, ISSN: 0962-8924.

Résumé | Liens | BibTeX | Étiquettes: Animals, Immunity, M3i, Protein Conformation, reichhart, Serine Proteinase Inhibitors, Serpins

2003

Ligoxygakis Petros, Roth Siegfried, Reichhart Jean-Marc

A serpin regulates dorsal-ventral axis formation in the Drosophila embryo Article de journal

Dans: Curr. Biol., 13 (23), p. 2097–2102, 2003, ISSN: 0960-9822.

Résumé | BibTeX | Étiquettes: Animals, Body Patterning, Cell Surface, Crosses, Female, Genetic, Immunohistochemistry, M3i, Microinjections, Receptors, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors

Goto Akira, Blandin Stéphanie A, Royet Julien, Reichhart Jean-Marc, Levashina Elena A

Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies Article de journal

Dans: Nucleic Acids Res., 31 (22), p. 6619–6623, 2003, ISSN: 1362-4962.

Résumé | BibTeX | Étiquettes: Animals, blandin, Cell Surface, Double-Stranded, Epistasis, Female, Genetic, Green Fluorescent Proteins, Homeodomain Proteins, Luminescent Proteins, M3i, Phenotype, Receptors, reichhart, RNA, RNA Interference, Serpins, Signal Transduction, Time Factors, Toll-Like Receptors, Transcription Factors

Green Clare, Brown Gemma, Dafforn Timothy R, Reichhart Jean-Marc, Morley Terri, Lomas David A, Gubb David

Drosophila necrotic mutations mirror disease-associated variants of human serpins Article de journal

Dans: Development, 130 (7), p. 1473–1478, 2003, ISSN: 0950-1991.

Résumé | BibTeX | Étiquettes: Animals, Humans, M3i, Necrosis, reichhart, Serpins, Temperature, Urea

2002

Ligoxygakis Petros, Pelte Nadège, Ji Chuanyi, Leclerc Vincent, Duvic Bernard, Belvin Marcia, Jiang Haobo, Hoffmann Jules A, Reichhart Jean-Marc

A serpin mutant links Toll activation to melanization in the host defence of Drosophila Article de journal

Dans: EMBO J., 21 (23), p. 6330–6337, 2002, ISSN: 0261-4189.

Résumé | BibTeX | Étiquettes: Animals, Cell Surface, Hemolymph, hoffmann, infection, M3i, Melanins, Receptors, reichhart, Serpins, Toll-Like Receptors

Christophides George K, Zdobnov Evgeny, Barillas-Mury Carolina, Birney Ewan, Blandin Stephanie A, Blass Claudia, Brey Paul T, Collins Frank H, Danielli Alberto, Dimopoulos George, Hetru Charles, Hoa Ngo T, Hoffmann Jules A, Kanzok Stefan M, Letunic Ivica, Levashina Elena A, Loukeris Thanasis G, Lycett Gareth, Meister Stephan, Michel Kristin, Moita Luis F, Müller Hans-Michael, Osta Mike A, Paskewitz Susan M, Reichhart Jean-Marc, Rzhetsky Andrey, Troxler Laurent, Vernick Kenneth D, Vlachou Dina, Volz Jennifer, von Mering Christian, Xu Jiannong, Zheng Liangbiao, Bork Peer, Kafatos Fotis C

Immunity-related genes and gene families in Anopheles gambiae Article de journal

Dans: Science, 298 (5591), p. 159–165, 2002, ISSN: 1095-9203.

Résumé | Liens | BibTeX | Étiquettes: Alternative Splicing, Animals, Anopheles, Apoptosis, bacteria, bioinformatic, blandin, Catechol Oxidase, Computational Biology, Enzyme Precursors, Gene Expression Regulation, Genes, Genetic, Genome, hoffmann, Immunity, Innate, Insect, Insect Proteins, M3i, Multigene Family, Peptides, Phylogeny, Plasmodium, Protein Structure, reichhart, Selection, Serine Endopeptidases, Serpins, Signal Transduction, Tertiary

1999

Levashina Elena A, Langley E, Green C, Gubb David, Ashburner M, Hoffmann Jules A, Reichhart Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Article de journal

Dans: Science, 285 (5435), p. 1917–1919, 1999, ISSN: 0036-8075.

Résumé | BibTeX | Étiquettes: Animals, Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, hoffmann, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation