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2017

Nehmar Ramzi, Alsaleh Ghada, Voisin Benjamin, Flacher Vincent, Mariotte Alexandre, Saferding Victoria, Puchner Antonia, Niederreiter Birgit, Vandamme Thierry, Schabbauer Gernot, Kastner Philippe, Chan Susan, Kirstetter Peggy, Holcmann Martin, Mueller Christopher, Sibilia Jean, Bahram Seiamak, Blüml Stephan, Georgel Philippe

Therapeutic Modulation of Plasmacytoid Dendritic Cells in Experimental Arthritis Article de journal

Dans: Arthritis & Rheumatology (Hoboken, N.J.), 69 (11), p. 2124–2135, 2017, ISSN: 2326-5205.

Résumé | Liens | BibTeX | Étiquettes: Activation, Adjuvants, Aminoquinolines, Analysis, Animal, Animals, arthritis, Assay, cancer, Cells, cytokine, Cytokines, Dendritic Cells, DEPLETION, Disease Models, drug effects, Enzyme-Linked Immunosorbent Assay, Experimental, Flow Cytometry, Gene Expression Profiling, Genetics, GLYCOPROTEIN, Glycoproteins, Human, Humans, IFN, IKAROS, Ikaros Transcription Factor, imiquimod, Immunologic, Immunology, immunopathology, inflammation, interferon, Interferon Type I, interferons, Knockout, Membrane, Membrane Glycoproteins, METHOD, methods, Mice, MODULATION, mouse, Necrosis, NECROSIS-FACTOR-ALPHA, pathogenesis, Patients, Pharmacology, physiology, plasmacytoid dendritic cells, Protein, Receptor, Reverse Transcriptase Polymerase Chain Reaction, rheumatoid, rheumatoid arthritis, Serum, signaling, Team-Mueller, TLR7, Toll-Like Receptor 7, TOPICAL APPLICATION, Transcription, TRANSCRIPTION FACTOR, transcriptome, transgenic, tumor, Tumor Necrosis Factor, Tumor Necrosis Factor-alpha

2013

Baron Olga Lucia, van West Pieter, Industri Benoit, Ponchet Michel, Dubreuil Géraldine, Gourbal Benjamin, Reichhart Jean-Marc, Coustau Christine

Parental transfer of the antimicrobial protein LBP/BPI protects Biomphalaria glabrata eggs against oomycete infections Article de journal

Dans: PLoS Pathog., 9 (12), p. e1003792, 2013, ISSN: 1553-7374.

Résumé | Liens | BibTeX | Étiquettes: Acute-Phase Proteins, Animals, Antimicrobial Cationic Peptides, Biomphalaria, Blood Proteins, Carrier Proteins, Cell Membrane, Cell Membrane Permeability, Cloning, Escherichia coli, Female, Immunity, infection, M3i, Maternally-Acquired, Membrane Glycoproteins, Microbial Sensitivity Tests, Molecular, Oomycetes, Recombinant Proteins, reichhart, Zygote

2006

Marmey B, Boix C, Barbaroux J B, Dieu-Nosjean M C, Diebold J, Audouin J, Fridman W H, Mueller C G, Molina T J

CD14 and CD169 expression in human lymph nodes and spleen: specific expansion of CD14+C Article de journal

Dans: Hum.Pathol., 37 (0046-8177 (Print)), p. 68–77, 2006.

Résumé | BibTeX | Étiquettes: Adhesion, Antigen, Antigens, B-Cell, Biological, CD14, Cell Differentiation, CELL SEPARATION, Dendritic Cells, Differentiation, Diffuse, Direct, Expression, Flow Cytometry, Fluorescent Antibody Technique, Gene, GLYCOPROTEIN, Glycoproteins, granulocyte/macrophage-colony, Human, Humans, Immunoenzyme Techniques, Immunohistochemistry, Immunologic, Large B-Cell, leukemia, LYMPH, LYMPH NODE, Lymph Nodes, Lymphadenitis, Lymphoid Tissue, LYMPHOMA, Macrophage, Macrophages, Membrane, Membrane Glycoproteins, metabolism, Monocytes, pathology, Phagocytosis, Receptor, Receptors, SIALOADHESIN, SPLEEN, Team-Mueller, tumor, Tumor Markers

Barbaroux Jean-Baptiste, Kwan Wing-Hong, Allam Jean-Pierre, Novak Natalija, Bieber Thomas, Fridman Wolf H, Groves Richard, Mueller Chris G

Tumor necrosis factor-alpha- and IL-4-independent development of Langerhans cell-like dendritic cells from M-CSF-conditioned precursors Article de journal

Dans: The Journal of Investigative Dermatology, 126 (1), p. 114–120, 2006, ISSN: 0022-202X.

Résumé | Liens | BibTeX | Étiquettes: Antigens, C-Type, Carrier Proteins, CC, CCR6, CD, CD1, CD34, Cell Differentiation, Chemokine, Chemokine CCL20, chemokines, Cytokines, DERMIS, FRANZ, Granulocyte-Macrophage Colony-Stimulating Factor, Hematopoietic Stem Cells, Humans, IL-4, Interleukin-4, Langerhans Cells, Lectins, Lipopolysaccharide Receptors, M-CSF, Macrophage Colony-Stimulating Factor, Macrophage Inflammatory Proteins, Mannose-Binding Lectins, Membrane Glycoproteins, murine, RANK ligand, Receptor Activator of Nuclear Factor-kappa B, Receptors, Surface, Team-Mueller, TNF ALPHA, Tumor Necrosis Factor-alpha

2005

Martinelli Cosimo, Reichhart Jean-Marc

Evolution and integration of innate immune systems from fruit flies to man: lessons and questions Article de journal

Dans: J. Endotoxin Res., 11 (4), p. 243–248, 2005, ISSN: 0968-0519.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological Evolution, Cell Surface, Forecasting, Humans, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Weber Alexander N R, Moncrieffe Martin C, Gangloff Monique, Imler Jean-Luc, Gay Nicholas J

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway Article de journal

Dans: The Journal of Biological Chemistry, 280 (24), p. 22793–22799, 2005, ISSN: 0021-9258.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Biophysical Phenomena, Biophysics, Body Patterning, Calorimetry, Cell Line, Cell Surface, Cross-Linking Reagents, Cytokines, dimerization, Electrophoresis, Humans, imler, ligands, Luciferases, M3i, Membrane Glycoproteins, Polyacrylamide Gel, Protein Binding, Protein Structure, Receptors, Recombinant Proteins, Sequence Homology, Signal Transduction, Tertiary, Time Factors, Toll-Like Receptors, Ultracentrifugation

2004

Imler Jean-Luc, Zheng Liangbiao

Biology of Toll receptors: lessons from insects and mammals Article de journal

Dans: Journal of Leukocyte Biology, 75 (1), p. 18–26, 2004, ISSN: 0741-5400.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anopheles, Cell Surface, Humans, imler, M3i, Membrane Glycoproteins, Mice, Phylogeny, Plant Physiological Phenomena, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Imler Jean-Luc, Ferrandon Dominique, Royet Julien, Reichhart Jean-Marc, Hetru Charles, Hoffmann Jules A

Toll-dependent and Toll-independent immune responses in Drosophila Article de journal

Dans: Journal of Endotoxin Research, 10 (4), p. 241–246, 2004, ISSN: 0968-0519.

Résumé | Liens | BibTeX | Étiquettes: Acute-Phase Proteins, Animals, Blood Proteins, Cell Surface, ferrandon, hoffmann, imler, Insect Proteins, M3i, Membrane Glycoproteins, Receptors, reichhart, Toll-Like Receptor 5, Toll-Like Receptors, Up-Regulation

2003

Reichhart Jean-Marc

TLR5 takes aim at bacterial propeller Article de journal

Dans: Nat. Immunol., 4 (12), p. 1159–1160, 2003, ISSN: 1529-2908.

Liens | BibTeX | Étiquettes: Animals, Bacterial Physiological Phenomena, Cell Surface, Flagella, Flagellin, Humans, M3i, Membrane Glycoproteins, Receptors, reichhart, Toll-Like Receptor 5, Toll-Like Receptors

Hoffmann Jules A

The immune response of Drosophila Article de journal

Dans: Nature, 426 (6962), p. 33–38, 2003, ISSN: 1476-4687.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Surface, hoffmann, Immunity, Innate, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Bilak Hana, Tauszig-Delamasure S, Imler Jean-Luc

Toll and Toll-like receptors in Drosophila Article de journal

Dans: Biochemical Society Transactions, 31 (Pt 3), p. 648–651, 2003, ISSN: 0300-5127.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological Evolution, Cell Surface, Fungi, Genome, Gram-Negative Bacteria, Gram-Positive Bacteria, imler, M3i, Membrane Glycoproteins, Receptors, Toll-Like Receptor 5, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Toll signaling: the TIReless quest for specificity Article de journal

Dans: Nature Immunology, 4 (2), p. 105–106, 2003, ISSN: 1529-2908.

Liens | BibTeX | Étiquettes: Animals, Cell Surface, Dendritic Cells, hoffmann, Humans, imler, Immunological, Interferon-beta, M3i, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

2002

Bates Elizabeth E M, Fridman Wolf H, Mueller Chris G F

The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12 Article de journal

Dans: Immunogenetics, 54 (2), p. 96–105, 2002, ISSN: 0093-7711.

Résumé | Liens | BibTeX | Étiquettes: ADAM Proteins, Amino Acid Sequence, Animals, Base Sequence, Chromosomes, Evolution, Gene Dosage, Gene Duplication, Genetic, Human, Humans, Inbred BALB C, Macaca mulatta, Membrane Glycoproteins, Metalloendopeptidases, Mice, Molecular, Molecular Sequence Data, Multigene Family, Pair 8, Promoter Regions, Sequence Alignment, Team-Mueller

Hoffmann Jules A, Reichhart Jean-Marc

Drosophila innate immunity: an evolutionary perspective Article de journal

Dans: Nat. Immunol., 3 (2), p. 121–126, 2002, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological Evolution, Cell Surface, hoffmann, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

Tauszig-Delamasure Servane, Bilak Hana, Capovilla Maria, Hoffmann Jules A, Imler Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Article de journal

Dans: Nature Immunology, 3 (1), p. 91–97, 2002, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Adaptor Proteins, Amino Acid, Animals, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, hoffmann, Hypocreales, imler, Immunologic, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

2001

Michel T, Reichhart Jean-Marc, Hoffmann Jules A, Royet Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Article de journal

Dans: Nature, 414 (6865), p. 756–759, 2001, ISSN: 0028-0836.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, hoffmann, Humans, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, reichhart, Sequence Homology, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Toll receptors in innate immunity Article de journal

Dans: Trends in Cell Biology, 11 (7), p. 304–311, 2001, ISSN: 0962-8924.

Résumé | BibTeX | Étiquettes: Animals, Cell Surface, hoffmann, Humans, imler, Immunity, Immunologic, Innate, M3i, Membrane Glycoproteins, Membrane Proteins, Receptors, Toll-Like Receptors

2000

Lagueux Marie, Perrodou E, Levashina Elena A, Capovilla Maria, Hoffmann Jules A

Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila Article de journal

Dans: Proc. Natl. Acad. Sci. U.S.A., 97 (21), p. 11427–11432, 2000, ISSN: 0027-8424.

Résumé | Liens | BibTeX | Étiquettes: alpha-Macroglobulins, Amino Acid, Animals, Cell Surface, Complement C3, Esters, Genetic, hoffmann, Insect Proteins, Janus Kinases, M3i, Membrane Glycoproteins, Mutation, Protein-Tyrosine Kinases, Proteins, Receptors, Sequence Homology, Sulfhydryl Compounds, Toll-Like Receptors, Transcription, Transcription Factors

Rutschmann Sophie, Jung Alain C, Zhou R, Silverman N, Hoffmann Jules A, Ferrandon Dominique

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response Article de journal

Dans: Nat. Immunol., 1 (4), p. 342–347, 2000, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antigens, Bacterial, Cell Surface, ferrandon, Gene Expression Regulation, hoffmann, I-kappa B Kinase, Immunity, Innate, Insect Proteins, M3i, Membrane Glycoproteins, Protein-Serine-Threonine Kinases, Receptors, Signal Transduction, Toll-Like Receptors, Transcription Factors

Tauszig Servane, Jouanguy Emmanuelle, Hoffmann Jules A, Imler Jean-Luc

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila Article de journal

Dans: Proceedings of the National Academy of Sciences of the United States of America, 97 (19), p. 10520–10525, 2000, ISSN: 0027-8424.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Blotting, Cell Line, Cell Surface, hoffmann, imler, M3i, Membrane Glycoproteins, Multigene Family, Northern, Peptides, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Signaling mechanisms in the antimicrobial host defense of Drosophila Article de journal

Dans: Current Opinion in Microbiology, 3 (1), p. 16–22, 2000, ISSN: 1369-5274.

Résumé | BibTeX | Étiquettes: Animals, Anti-Infective Agents, Cell Surface, Gene Expression Regulation, Genes, hoffmann, imler, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptors

Imler Jean-Luc, Tauszig Servane, Jouanguy Emmanuelle, Forestier C, Hoffmann Jules A

LPS-induced immune response in Drosophila Article de journal

Dans: Journal of Endotoxin Research, 6 (6), p. 459–462, 2000, ISSN: 0968-0519.

Résumé | BibTeX | Étiquettes: Animals, Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, hoffmann, imler, Insect, Insect Proteins, Lipopolysaccharides, M3i, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

Imler Jean-Luc, Hoffmann Jules A

Toll and Toll-like proteins: an ancient family of receptors signaling infection Article de journal

Dans: Reviews in Immunogenetics, 2 (3), p. 294–304, 2000, ISSN: 1398-1714.

Résumé | BibTeX | Étiquettes: Adaptor Proteins, Animals, Antigens, Autoantigens, CD14, Cell Adhesion Molecules, Cell Surface, Differentiation, DNA-Binding Proteins, Gene Expression Regulation, hoffmann, I-kappa B Proteins, imler, Immunity, Immunologic, infection, Innate, Insect Proteins, Interleukin-1 Receptor-Associated Kinases, Knockout, Larva, Lipopolysaccharides, M3i, Mammals, MAP Kinase Signaling System, Membrane Glycoproteins, Membrane Proteins, Mice, Multigene Family, Myeloid Differentiation Factor 88, NF-kappa B, peptidoglycan, Phosphorylation, Post-Translational, Protein Kinases, Protein Processing, Protein Structure, Receptors, Recombinant Fusion Proteins, Signal Transducing, Signal Transduction, Teichoic Acids, Tertiary, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptor 6, Toll-Like Receptor 9, Toll-Like Receptors, Ubiquitins

1999

Levashina Elena A, Langley E, Green C, Gubb David, Ashburner M, Hoffmann Jules A, Reichhart Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Article de journal

Dans: Science, 285 (5435), p. 1917–1919, 1999, ISSN: 0036-8075.

Résumé | BibTeX | Étiquettes: Animals, Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, hoffmann, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

Manfruelli P, Reichhart Jean-Marc, Steward R, Hoffmann Jules A, Lemaitre Bruno

A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF Article de journal

Dans: EMBO J., 18 (12), p. 3380–3391, 1999, ISSN: 0261-4189.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anti-Infective Agents, Cell Surface, Clone Cells, DNA-Binding Proteins, Fat Body, Female, Gene Expression Regulation, Genes, hoffmann, Insect, Insect Proteins, Larva, M3i, Male, Membrane Glycoproteins, Mosaicism, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, reichhart, Reporter, Signal Transduction, Toll-Like Receptors, Transcription Factors

1998

Ferrandon Dominique, Jung Alain C, Criqui M, Lemaitre Bruno, Uttenweiler-Joseph S, Michaut Lydia, Reichhart Jean-Marc, Hoffmann Jules A

A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway Article de journal

Dans: EMBO J., 17 (5), p. 1217–1227, 1998, ISSN: 0261-4189.

Résumé | Liens | BibTeX | Étiquettes: Animals, bacteria, Cell Surface, Developmental, Digestive System, Epithelium, Fat Body, Female, ferrandon, Fungal, Gene Expression Regulation, Genes, Green Fluorescent Proteins, hoffmann, Insect Proteins, Larva, Luminescent Proteins, M3i, Male, Membrane Glycoproteins, Organ Specificity, Receptors, reichhart, Reporter, Respiratory System, Spores, Toll-Like Receptors, Trachea, Transgenes

Nicolas E, Reichhart Jean-Marc, Hoffmann Jules A, Lemaitre Bruno

In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila Article de journal

Dans: J. Biol. Chem., 273 (17), p. 10463–10469, 1998, ISSN: 0021-9258.

Résumé | BibTeX | Étiquettes: Animals, Cell Surface, DNA-Binding Proteins, Gene Expression Regulation, hoffmann, Insect Proteins, Larva, M3i, Membrane Glycoproteins, Phosphoproteins, Proto-Oncogene Proteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors, Transcription Factor RelB, Transcription Factors

1996

Lemaitre Bruno, Nicolas E, Michaut Lydia, Reichhart Jean-Marc, Hoffmann Jules A

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults Article de journal

Dans: Cell, 86 (6), p. 973–983, 1996, ISSN: 0092-8674.

Résumé | BibTeX | Étiquettes: Animals, Antifungal Agents, Cell Surface, DNA-Binding Proteins, Fungi, Gene Expression, Genes, hoffmann, Insect, Insect Hormones, Insect Proteins, M3i, Membrane Glycoproteins, MHC Class II, Mutation, Mycoses, NF-kappa B, Phosphoproteins, Proteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

1995

Lemaitre Bruno, Meister Marie, Govind S, Georgel Philippe, Steward R, Reichhart Jean-Marc, Hoffmann Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Article de journal

Dans: EMBO J., 14 (3), p. 536–545, 1995, ISSN: 0261-4189.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, hoffmann, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, M3i, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors