Publications
2008
Lacerda L, Soundararajan A, Singh R, Pastorin G, Al‐Jamal K T, Turton J, Frederik P, Herrero M A, Li S, Bao A, Emfietzoglou D, Mather S, Phillips W T, Prato M, Bianco A, Goins B, Kostarelos K
Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion Article de journal
Dans: Advanced Materials, vol. 20, no. 2, p. 225–230, 2008, ISSN: 1521-4095.
Résumé | Liens | BibTeX | Étiquettes: Biomedical applications, Carbon nanotubes, I2CT, multiwalled, Nanomaterials, Team-Bianco
@article{lacerda_dynamic_2008,
title = {Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion},
author = {L Lacerda and A Soundararajan and R Singh and G Pastorin and K T Al‐Jamal and J Turton and P Frederik and M A Herrero and S Li and A Bao and D Emfietzoglou and S Mather and W T Phillips and M Prato and A Bianco and B Goins and K Kostarelos},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.200702334},
doi = {10.1002/adma.200702334},
issn = {1521-4095},
year = {2008},
date = {2008-01-01},
urldate = {2020-03-31},
journal = {Advanced Materials},
volume = {20},
number = {2},
pages = {225--230},
abstract = {Intravenously administered multi-walled carbon nanotubes, functionalized with DTPA and radiolabeled with Indium-111, were dynamically tracked in vivo using a microSingle Photon Emission Tomography scanner. Imaging showed that nanotubes enter the systemic blood circulation and within 5 min begin to permeate through the renal glomerular filtration system into the bladder.},
keywords = {Biomedical applications, Carbon nanotubes, I2CT, multiwalled, Nanomaterials, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
2006
Lacerda L, Pastorin G, Wu W, Prato M, Bianco A, Kostarelos K
Luminescence of Functionalized Carbon Nanotubes as a Tool to Monitor Bundle Formation and Dissociation in Water: The Effect of Plasmid-DNA Complexation Article de journal
Dans: Advanced Functional Materials, vol. 16, no. 14, p. 1839–1846, 2006, ISSN: 1616-3028.
Résumé | Liens | BibTeX | Étiquettes: Carbon nanotubes, DNA, I2CT, Luminescence, multiwalled, single-walled, Team-Bianco
@article{lacerda_luminescence_2006,
title = {Luminescence of Functionalized Carbon Nanotubes as a Tool to Monitor Bundle Formation and Dissociation in Water: The Effect of Plasmid-DNA Complexation},
author = {L Lacerda and G Pastorin and W Wu and M Prato and A Bianco and K Kostarelos},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.200500569},
doi = {10.1002/adfm.200500569},
issn = {1616-3028},
year = {2006},
date = {2006-01-01},
urldate = {2020-03-31},
journal = {Advanced Functional Materials},
volume = {16},
number = {14},
pages = {1839--1846},
abstract = {Functionalized carbon nanotubes (f-CNTs) are explored as novel nanomaterials for biomedical applications. UV-vis luminescence of aqueous dispersions of CNT–NH3+ and CNT–NH–Ac (NH–Ac: acetamido) is observed using standard laboratory spectrophotometric instrumentation, and the measured fluorescence intensity is correlated with the aggregation state of the f-CNTs: a high intensity indicates improved f-CNT individualization and dispersion, while a decrease in fluorescence intensity indicates a higher degree of nanotube aggregation and bundling as a result of varying the sodium dodecyl sulfate (SDS) concentrations and pH in the aqueous phase. Moreover, utilization of this relationship between fluorescence intensity and the state of f-CNT aggregation is carried out to elucidate the interactions between f-CNTs and gene-encoding plasmid DNA (pDNA). pDNA is shown to interact with CNT–NH3+ primarily through electrostatic interactions that lead concomitantly to a higher degree of f-CNT bundling. The CNT–NH3+/pDNA interactions are successfully competed by SDS/f-CNT surface interactions, resulting in the displacement of pDNA. These studies provide exemplification of the use of fluorescence spectrophotometry to accurately describe the aggregation state of water-soluble f-CNTs. Characterization of the complexes between pDNA and f-CNTs elucidates the opportunities and limitations of such supramolecular systems as potential vectors for gene transfer.},
keywords = {Carbon nanotubes, DNA, I2CT, Luminescence, multiwalled, single-walled, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}