Imagerie PI2

@article{C2021c,

title = {Structure-Switching RNAs: From Gene Expression Regulation to Small Molecule Detection},

author = {C Husser and N Dentz and M Ryckelynck},

url = {https://doi.org/10.1002/sstr.202000132},

doi = {10.1002/sstr.202000132},

year  = {2021},

date = {2021-01-01},

journal = {Small Structures},

volume = {2},

number = {4},

pages = {2000132},

abstract = {RNA is instrumental to cell life in many aspects, especially gene expression regulation. Among the various known regulatory RNAs, riboswitches are particularly interesting cis‐acting molecules as they do not need cellular factor to achieve their function and are therefore highly portable from one organism to the other. These molecules usually found in the 5′ untranslated region of bacterial messenger RNAs are able to specifically sense a target ligand via an aptamer domain prior to transmitting this recognition event to an expression platform that turns on, or off, the expression of downstream genes. In addition to their obvious scientific interest, these modular molecules can also serve for the development of synthetic RNA devices with applications ranging from the control of transgene expression in gene therapy to the specific biosensing of small molecules. The engineering of such nanomachines is greatly facilitated by the proper understanding of their structure as well as the introduction of new technologies. Herein, a general overview of the current knowledge on natural riboswitches prior to explaining the main strategies used to develop new synthetic structure‐switching molecules (riboswitches or biosensors) controlled by small molecules is given.},

keywords = {biosensing, Gene Expression Regulation, riboswitches, RNA aptamers, RYCKELYNCK, Synthetic Biology, Unité ARN},

pubstate = {published},

tppubtype = {article}

}

@article{servant_graphene_2014,

title = {Graphene for multi-functional synthetic biology: the last 'zeitgeist' in nanomedicine},

author = {A Servant and A Bianco and M Prato and K Kostarelos},

doi = {10.1016/j.bmcl.2014.01.051},

issn = {1464-3405},

year  = {2014},

date = {2014-01-01},

journal = {Bioorganic & Medicinal Chemistry Letters},

volume = {24},

number = {7},

pages = {1638--1649},

abstract = {The high versatility of graphene has attracted significant attention in many areas of scientific research from electronics to physics and mechanics. One of the most intriguing utilisation of graphene remains however in nanomedicine and synthetic biology. In particular, the last decade has witnessed an exponential growth in the generation of novel candidate therapeutics of multiple biological activities based on graphene constructs with small molecules, such as anti-cancer drugs. In this Digest, we summarise the different synthetic strategies and routes available to fabricate these promising graphene conjugates and the opportunities for the design of multi-functional tools for synthetic biology that they offer.},

keywords = {Antineoplastic Agents, carbon, Drug delivery, Drug Design, Graphite, I2CT, Nanomaterials, Nanomedicine, nanotechnology, Synthetic Biology, Team-Bianco},

pubstate = {published},

tppubtype = {article}

}