Publications
2003
Leontis N B, Westhof E
Analysis of RNA motifs Article de journal
Dans: Curr Opin Struct Biol, vol. 13, no. 3, p. 300-308, 2003, ISBN: 12831880, (0959-440x Journal Article Review Review, Tutorial).
Résumé | Liens | BibTeX | Étiquettes: *Base Pairing Binding Sites Magnetic Resonance Imaging *Nucleic Acid Conformation RNA/*chemistry RNA, Chloroplast/chemistry Support, P.H.S., U.S. Gov't, Unité ARN, WESTHOF
@article{,
title = {Analysis of RNA motifs},
author = {N B Leontis and E Westhof},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12831880},
isbn = {12831880},
year = {2003},
date = {2003-01-01},
journal = {Curr Opin Struct Biol},
volume = {13},
number = {3},
pages = {300-308},
abstract = {RNA motifs are directed and ordered stacked arrays of non-Watson-Crick base pairs forming distinctive foldings of the phosphodiester backbones of the interacting RNA strands. They correspond to the 'loops' - hairpin, internal and junction - that intersperse the Watson-Crick two-dimensional helices as seen in two-dimensional representations of RNA structure. RNA motifs mediate the specific interactions that induce the compact folding of complex RNAs. RNA motifs also constitute specific protein or ligand binding sites. A given motif is characterized by all the sequences that fold into essentially identical three-dimensional structures with the same ordered array of isosteric non-Watson-Crick base pairs. It is therefore crucial, when analyzing a three-dimensional RNA structure in order to identify and compare motifs, to first classify its non-Watson-Crick base pairs geometrically.},
note = {0959-440x
Journal Article
Review
Review, Tutorial},
keywords = {*Base Pairing Binding Sites Magnetic Resonance Imaging *Nucleic Acid Conformation RNA/*chemistry RNA, Chloroplast/chemistry Support, P.H.S., U.S. Gov't, Unité ARN, WESTHOF},
pubstate = {published},
tppubtype = {article}
}
RNA motifs are directed and ordered stacked arrays of non-Watson-Crick base pairs forming distinctive foldings of the phosphodiester backbones of the interacting RNA strands. They correspond to the 'loops' - hairpin, internal and junction - that intersperse the Watson-Crick two-dimensional helices as seen in two-dimensional representations of RNA structure. RNA motifs mediate the specific interactions that induce the compact folding of complex RNAs. RNA motifs also constitute specific protein or ligand binding sites. A given motif is characterized by all the sequences that fold into essentially identical three-dimensional structures with the same ordered array of isosteric non-Watson-Crick base pairs. It is therefore crucial, when analyzing a three-dimensional RNA structure in order to identify and compare motifs, to first classify its non-Watson-Crick base pairs geometrically.