Publications
2019
Fillatre Jonathan, Fauny Jean-Daniel, Fels Jasmine Alexandra, Li Cheng, Goll Mary, Thisse Christine, Thisse Bernard
TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish Article de journal
Dans: eLife, vol. 8, 2019, ISSN: 2050-084X.
Résumé | Liens | BibTeX | Étiquettes: Animals, Body Patterning, Developmental, developmental biology, Gene Expression Regulation, Hippo pathway, I2CT, Imagerie, Left-Right asymmetry, Left-Right Organizer, Signal Transduction, Taz, Transcription Factors, Vgll4, Yap, Zebrafish
@article{fillatre_teads_2019,
title = {TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish},
author = {Jonathan Fillatre and Jean-Daniel Fauny and Jasmine Alexandra Fels and Cheng Li and Mary Goll and Christine Thisse and Bernard Thisse},
doi = {10.7554/eLife.45241},
issn = {2050-084X},
year = {2019},
date = {2019-01-01},
journal = {eLife},
volume = {8},
abstract = {In many vertebrates, establishment of Left-Right (LR) asymmetry results from the activity of a ciliated organ functioning as the LR Organizer (LRO). While regulation of the formation of this structure by major signaling pathways has been described, the transcriptional control of LRO formation is poorly understood. Using the zebrafish model, we show that the transcription factors and cofactors mediating or regulating the transcriptional outcome of the Hippo signaling pathway play a pivotal role in controlling the expression of genes essential to the formation of the LRO including ligands and receptors of signaling pathways involved in this process and most genes required for motile ciliogenesis. Moreover, the transcription cofactor, Vgll4l regulates epigenetic programming in LRO progenitors by controlling the expression of writers and readers of DNA methylation marks. Altogether, our study uncovers a novel and essential role for the transcriptional effectors and regulators of the Hippo pathway in establishing LR asymmetry.},
keywords = {Animals, Body Patterning, Developmental, developmental biology, Gene Expression Regulation, Hippo pathway, I2CT, Imagerie, Left-Right asymmetry, Left-Right Organizer, Signal Transduction, Taz, Transcription Factors, Vgll4, Yap, Zebrafish},
pubstate = {published},
tppubtype = {article}
}
2009
Fauny Jean-Daniel, Thisse Bernard, Thisse Christine
The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity Article de journal
Dans: Development (Cambridge, England), vol. 136, no. 22, p. 3811–3819, 2009, ISSN: 1477-9129.
Résumé | Liens | BibTeX | Étiquettes: Animals, Blastula, Bone Morphogenetic Proteins, Embryonic, Gastrula, I2CT, Imagerie, Nodal Protein, Organizers, Zebrafish, Zebrafish Proteins
@article{fauny_entire_2009,
title = {The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity},
author = {Jean-Daniel Fauny and Bernard Thisse and Christine Thisse},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19855023},
doi = {10.1242/dev.039693},
issn = {1477-9129},
year = {2009},
date = {2009-01-01},
urldate = {2011-10-24},
journal = {Development (Cambridge, England)},
volume = {136},
number = {22},
pages = {3811--3819},
abstract = {Formation of the vertebrate embryo is known to depend on the activity of organizing centers. The dorsal Spemann organizer is the source of growth factor antagonists that participate in the creation of signaling gradients. In various species, the existence of head, trunk and trunk-tail inducers has been proposed to explain the formation of different parts of the embryo along the anteroposterior (A/P) axis. In zebrafish, two organizing centers have been described, the dorsal and tail organizers, located at the dorsal and ventral gastrula margins, respectively. Here, we report that organizer functions are executed not only by the dorsal and ventral margins, but also by all parts of the blastula-gastrula margin. The position of different marginal territories along the dorsoventral axis defines the A/P nature of the structures they are able to organize. At the molecular level, we show that this organizing activity results from the simultaneous activation of BMP and Nodal signaling pathways. Furthermore, the A/P character of the organized structures is not defined by absolute levels but instead by the ratio of BMP and Nodal activities. Rather than resulting from the activity of discrete centers, organization of the zebrafish embryo depends on the activity of the entire margin acting as a continuous and global organizer that is established by a gradual ventral-to-dorsal modulation of the ratio of marginal BMP to Nodal activity.},
keywords = {Animals, Blastula, Bone Morphogenetic Proteins, Embryonic, Gastrula, I2CT, Imagerie, Nodal Protein, Organizers, Zebrafish, Zebrafish Proteins},
pubstate = {published},
tppubtype = {article}
}