Imagerie PI2

@article{rutschmann_rel_2000,

title = {The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila},

author = {Sophie Rutschmann and Alain C Jung and Charles Hetru and Jean-Marc Reichhart and Jules A Hoffmann and Dominique Ferrandon},

issn = {1074-7613},

year  = {2000},

date = {2000-05-01},

journal = {Immunity},

volume = {12},

number = {5},

pages = {569--580},

abstract = {We have isolated two Drosophila lines that carry point mutations in the gene coding for the NF-KB-like factor DIF. Like mutants of the Toll pathway, Dif mutant flies are susceptible to fungal but not to bacterial infections. Genetic epistasis experiments demonstrate that Dif mediates the Toll-dependent control of the inducibility of the antifungal peptide gene Drosomycin. Strikingly, DIF alone is required for the antifungal response in adults, but is redundant in larvae with Dorsal, another Rel family member. In Drosophila, Dif appears to be dedicated to the antifungal defense elicited by fungi and gram-positive bacteria. We discuss in this light the possibility that NF-KB1/p50 might be required more specifically in the innate immune response against gram-positive bacteria in mammals.},

keywords = {Animals, Antigens, Bacterial, DNA-Binding Proteins, ferrandon, Fungal, hoffmann, Immunity, Innate, M3i, reichhart, Transcription Factors},

pubstate = {published},

tppubtype = {article}

}

@article{ferrandon_immunite_2000,

title = {L'immunité innée : de la drosophile à l'homme},

author = {Dominique Ferrandon and Charles Hetru and Jean-Marc Reichhart and Jules A Hoffmann},

year  = {2000},

date = {2000-01-01},

journal = {Pour la Science},

volume = {Dossier Hors Série Octobre},

pages = {8--12},

keywords = {ferrandon, hoffmann, M3i, reichhart},

pubstate = {published},

tppubtype = {article}

}

@article{tzou_tissue-specific_2000b,

title = {Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia},

author = {P Tzou and S Ohresser and Dominique Ferrandon and Maria Capovilla and Jean-Marc Reichhart and Bruno Lemaitre and Jules A Hoffmann and Jean-Luc Imler},

issn = {1074-7613},

year  = {2000},

date = {2000-01-01},

journal = {Immunity},

volume = {13},

pages = {737--48.},

abstract = {The production of antimicrobial peptides is an important aspect of host defense in multicellular organisms. In Drosophila, seven antimicrobial peptides with different spectra of activities are synthesized by the fat body during the immune response and secreted into the hemolymph. Using GFP reporter transgenes, we show here that all seven Drosophila antimicrobial peptides can be induced in surface epithelia in a tissue-specific manner. The imd gene plays a critical role in the activation of this local response to infection. In particular, drosomycin expression, which is regulated by the Toll pathway during the systemic response, is regulated by imd in the respiratory tract, thus demonstrating the existence of distinct regulatory mechanisms for local and systemic induction of antimicrobial peptide genes in Drosophila.},

keywords = {*Genes, Animal, Anti-Infective Agents/*immunology/metabolism, Drosophila/genetics/*immunology, ferrandon, Gene Expression Regulation/*immunology, Genes, Glycoside Hydrolases/immunology, hoffmann, Human, imler, Insect, Insect Proteins/genetics/immunology, M3i, Non-U.S. Gov't, Organ Specificity, P.H.S., reichhart, Reporter, Support, Transfection, U.S. Gov't},

pubstate = {published},

tppubtype = {article}

}

@article{ferrandon_drosomycin-gfp_1998,

title = {A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway},

author = {Dominique Ferrandon and Alain C Jung and M Criqui and Bruno Lemaitre and S Uttenweiler-Joseph and Lydia Michaut and Jean-Marc Reichhart and Jules A Hoffmann},

doi = {10.1093/emboj/17.5.1217},

issn = {0261-4189},

year  = {1998},

date = {1998-08-01},

journal = {EMBO J.},

volume = {17},

number = {5},

pages = {1217--1227},

abstract = {A hallmark of the systemic antimicrobial response of Drosophila is the synthesis by the fat body of several antimicrobial peptides which are released into the hemolymph in response to a septic injury. One of these peptides, drosomycin, is active primarily against fungi. Using a drosomycin-green fluorescent protein (GFP) reporter gene, we now show that in addition to the fat body, a variety of epithelial tissues that are in direct contact with the external environment, including those of the respiratory, digestive and reproductive tracts, can express the antifungal peptide, suggesting a local response to infections affecting these barrier tissues. As is the case for vertebrate epithelia, insect epithelia appear to be more than passive physical barriers and are likely to constitute an active component of innate immunity. We also show that, in contrast to the systemic antifungal response, this local immune response is independent of the Toll pathway.},

keywords = {Animals, bacteria, Cell Surface, Developmental, Digestive System, Epithelium, Fat Body, Female, ferrandon, Fungal, Gene Expression Regulation, Genes, Green Fluorescent Proteins, hoffmann, Insect Proteins, Larva, Luminescent Proteins, M3i, Male, Membrane Glycoproteins, Organ Specificity, Receptors, reichhart, Reporter, Respiratory System, Spores, Toll-Like Receptors, Trachea, Transgenes},

pubstate = {published},

tppubtype = {article}

}

@article{reichhart_green_1998,

title = {Green Balancers.},

author = {Jean-Marc Reichhart and Dominique Ferrandon},

year  = {1998},

date = {1998-01-01},

journal = {D. I. S.},

volume = {81},

pages = {201--202},

abstract = {We have used the S65T green fluorescent protein (GFP ; (Chalfie et al., 1994) ; (Heim et al., 1995)) as a vital reporter to introduce a dominant innocuous marker onto the balancers of the three major chromosomes of D. melanogaster.},

keywords = {ferrandon, M3i, reichhart},

pubstate = {published},

tppubtype = {article}

}

@article{ferrandon_staufen_1994b,

title = {Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner},

author = {Dominique Ferrandon and L Elphick and C Nüsslein-Volhard and St D Johnston},

issn = {0092-8674},

year  = {1994},

date = {1994-12-01},

journal = {Cell},

volume = {79},

number = {7},

pages = {1221--1232},

abstract = {Staufen protein is required in order to anchor bicoid (bcd) mRNA at the anterior pole of the Drosophila egg. Here we show that staufen protein colocalizes with bcd mRNA at the anterior, and that this localization depends upon its association with the mRNA. Upon injection into the embryo, bcd transcripts specifically interact with staufen, and we have mapped the sequences required to three regions of the 3'UTR, each of which is predicted to form a long stem-loop. The resulting staufen-bcd 3'UTR complexes form particles that show a microtubule-dependent localization. Since staufen is also transported with oskar (osk) mRNA during oogenesis, staufen associates specifically with both osk and bcd mRNAs to mediate their localizations, but at two distinct stages of development.},

keywords = {Animals, Base Sequence, Cell Polarity, ferrandon, Homeodomain Proteins, Insect Hormones, M3i, messenger, Microtubules, Nucleic Acid Conformation, Oocytes, RNA, RNA-Binding Proteins, Trans-Activators},

pubstate = {published},

tppubtype = {article}

}

@article{ferrandon_localisation_1992,

title = {The localisation of the maternal signals that determine the anterior-posterior axis in the Drosophila embryo},

author = {Dominique Ferrandon and St D Johnston},

year  = {1992},

date = {1992-01-01},

journal = {Seminars in Developmental Biology},

volume = {3},

pages = {3--13},

keywords = {ferrandon, M3i},

pubstate = {published},

tppubtype = {article}

}