@inbook{,
title = {Mitochondrial aminoacyl-tRNA synthetases},
author = {M Sissler and J Putz and F Fasiolo and C Florentz},
editor = {M Ibba and C Francklyn and S Cusak},
url = {http://www.ncbi.nlm.nih.gov/books/NBK6033},
year = {2005},
date = {2005-01-01},
booktitle = {The Aminoacyl-tRNA Synthetases},
publisher = {Landes Bioscience},
abstract = {Mitochondria and chloroplasts have their own genomes that encode a small number of proteins whose synthesis depends on translation machineries of multiple origin. Whereas tRNAs, rRNAs and some ribosomal proteins are often encoded by the organellar genome, all other factors and in particular aminoacyl-tRNA synthetases (aaRSs) are nuclear encoded, synthesized in the cytosol and imported. Thus, two to three sets of aaRSs coexist in eukaryotic cells, namely cytosolic, mitochondrial and chloroplastic versions. Here, the diversity in the structural and functional properties of organellar aaRSs is illustrated by mammalian mitochondrial aaRSs (size, oligomeric structure, efficiency of aminoacylation, cross reactions, identity sets). Additionally, means by which nuclear genes encode cytosolic, mitochondrial and chloroplastic aaRSs are reviewed on the basis of database exploration on fully sequenced (although not completely annotated) genomes of Homo sapiens, Saccharomyces cerevisiae, Caenorabditis elegans, Drosophila melanogaster and Arabidopsis thaliana.},
keywords = {FLORENTZ, FLORENTZ FASIOLO, SISSLER, Unité ARN},
pubstate = {published},
tppubtype = {inbook}
}
Mitochondria and chloroplasts have their own genomes that encode a small number of proteins whose synthesis depends on translation machineries of multiple origin. Whereas tRNAs, rRNAs and some ribosomal proteins are often encoded by the organellar genome, all other factors and in particular aminoacyl-tRNA synthetases (aaRSs) are nuclear encoded, synthesized in the cytosol and imported. Thus, two to three sets of aaRSs coexist in eukaryotic cells, namely cytosolic, mitochondrial and chloroplastic versions. Here, the diversity in the structural and functional properties of organellar aaRSs is illustrated by mammalian mitochondrial aaRSs (size, oligomeric structure, efficiency of aminoacylation, cross reactions, identity sets). Additionally, means by which nuclear genes encode cytosolic, mitochondrial and chloroplastic aaRSs are reviewed on the basis of database exploration on fully sequenced (although not completely annotated) genomes of Homo sapiens, Saccharomyces cerevisiae, Caenorabditis elegans, Drosophila melanogaster and Arabidopsis thaliana.