Publications
2014
Frechin Mathieu, Enkler Ludovic, Tetaud Emmanuel, Laporte Daphné, Senger Bruno, Blancard Corinne, Hammann Philippe, Bader Gaétan, Clauder-Münster Sandra, Steinmetz Lars M, Martin Robert Pierre, di Rago Jean-Paul, Becker Hubert Dominique
Expression of nuclear and mitochondrial genes encoding ATP synthase is synchronized by disassembly of a multisynthetase complex. Article de journal
Dans: Molecular cell, vol. 56, no. 6, p. 763–776, 2014, ISSN: 1097-4164 1097-2765, (Place: United States).
Résumé | Liens | BibTeX | Étiquettes: Cell Nucleus/genetics, Fungal, Gene Expression, Gene Expression Regulation, Mitochondria/genetics, Multienzyme Complexes, PPSE, Protein Multimerization, Proton-Translocating ATPases/*genetics/metabolism, RNA-Binding Proteins/physiology, Saccharomyces cerevisiae Proteins/physiology, Saccharomyces cerevisiae/enzymology/*genetics
@article{frechin_expression_2014,
title = {Expression of nuclear and mitochondrial genes encoding ATP synthase is synchronized by disassembly of a multisynthetase complex.},
author = {Mathieu Frechin and Ludovic Enkler and Emmanuel Tetaud and Daphné Laporte and Bruno Senger and Corinne Blancard and Philippe Hammann and Gaétan Bader and Sandra Clauder-Münster and Lars M Steinmetz and Robert Pierre Martin and Jean-Paul di Rago and Hubert Dominique Becker},
doi = {10.1016/j.molcel.2014.10.015},
issn = {1097-4164 1097-2765},
year = {2014},
date = {2014-12-01},
journal = {Molecular cell},
volume = {56},
number = {6},
pages = {763--776},
abstract = {In eukaryotic cells, oxidative phosphorylation involves multisubunit complexes of mixed genetic origin. Assembling these complexes requires an organelle-independent synchronizing system for the proper expression of nuclear and mitochondrial genes. Here we show that proper expression of the F1FO ATP synthase (complex V) depends on a cytosolic complex (AME) made of two aminoacyl-tRNA synthetases (cERS and cMRS) attached to an anchor protein, Arc1p. When yeast cells adapt to respiration the Snf1/4 glucose-sensing pathway inhibits ARC1 expression triggering simultaneous release of cERS and cMRS. Free cMRS and cERS relocate to the nucleus and mitochondria, respectively, to synchronize nuclear transcription and mitochondrial translation of ATP synthase genes. Strains releasing asynchronously the two aminoacyl-tRNA synthetases display aberrant expression of nuclear and mitochondrial genes encoding subunits of complex V resulting in severe defects of the oxidative phosphorylation mechanism. This work shows that the AME complex coordinates expression of enzymes that require intergenomic control.},
note = {Place: United States},
keywords = {Cell Nucleus/genetics, Fungal, Gene Expression, Gene Expression Regulation, Mitochondria/genetics, Multienzyme Complexes, PPSE, Protein Multimerization, Proton-Translocating ATPases/*genetics/metabolism, RNA-Binding Proteins/physiology, Saccharomyces cerevisiae Proteins/physiology, Saccharomyces cerevisiae/enzymology/*genetics},
pubstate = {published},
tppubtype = {article}
}