@inbook{,
title = {Transfer RNA structure},
author = {E Westhof and P Auffinger},
url = {http://www.els.net/WileyCDA/ElsArticle/refId-a0000527.html},
doi = {10.1002/9780470015902.a0000527.pub2},
year = {2012},
date = {2012-01-01},
booktitle = {Encyclopedia of Life Sciences},
publisher = {John Wiley & Sons},
abstract = {Transfer ribonucleic acid (tRNA) molecules that participate
in the elongation step of protein synthesis on the
ribosome have a conserved secondary structure, known as
the cloverleaf, and fold into a common three-dimensional
architecture. The conservation of the global L-shaped 3D
fold is assessed by the more than 100 available crystal
structures showing tRNAs in native states or in complexes
where tRNAs are bound to various interacting systems
such as cognate synthetases, editing, modification and
processing enzymes or full ribosomes. These tRNA crystal
structures display awhole range of structural adaptability
features encoded in their sequence and underlying their
various functions. Thus, as the number of available structural
data expands, the concept of a unique tRNA structure
fades out for that of an ensemble of interconnected
and environmentally dependant tRNA structures.},
keywords = {transfer ribonucleic acid tRNA cloverleaf structure wobble hypothesis anticodon WatsonCrick pairs non-WatsonCrick pairs hydrogen bond Hoogsteen pairs dynamics solvation magnesium, Unité ARN, WESTHOF},
pubstate = {published},
tppubtype = {inbook}
}
Transfer ribonucleic acid (tRNA) molecules that participate
in the elongation step of protein synthesis on the
ribosome have a conserved secondary structure, known as
the cloverleaf, and fold into a common three-dimensional
architecture. The conservation of the global L-shaped 3D
fold is assessed by the more than 100 available crystal
structures showing tRNAs in native states or in complexes
where tRNAs are bound to various interacting systems
such as cognate synthetases, editing, modification and
processing enzymes or full ribosomes. These tRNA crystal
structures display awhole range of structural adaptability
features encoded in their sequence and underlying their
various functions. Thus, as the number of available structural
data expands, the concept of a unique tRNA structure
fades out for that of an ensemble of interconnected
and environmentally dependant tRNA structures.
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