Publications
2014
Tomasini A, François P, Howden B P, Fechter P, Romby P, Caldelari I
The importance of regulatory RNAs in Staphylococcus aureus. Journal Article
In: Infect Genet Evol, vol. 21, no. C, pp. 616-626, 2014, ISBN: 24291227.
Abstract | Links | BibTeX | Tags: Regulatory RNA Staphylococcus Virulence, ROMBY, Unité ARN
@article{,
title = {The importance of regulatory RNAs in Staphylococcus aureus.},
author = {A Tomasini and P François and B P Howden and P Fechter and P Romby and I Caldelari},
url = {http://www.ncbi.nlm.nih.gov/pubmed/24291227},
doi = {10.1016/j.meegid.2013.11.016},
isbn = {24291227},
year = {2014},
date = {2014-01-01},
journal = {Infect Genet Evol},
volume = {21},
number = {C},
pages = {616-626},
abstract = {RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.},
keywords = {Regulatory RNA Staphylococcus Virulence, ROMBY, Unité ARN},
pubstate = {published},
tppubtype = {article}
}
RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.