Publications
2011
Ménard-Moyon Cécilia, Fabbro Chiara, Prato Maurizio, Bianco Alberto
One-pot triple functionalization of carbon nanotubes Journal Article
In: Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 17, no. 11, pp. 3222–3227, 2011, ISSN: 1521-3765.
Abstract | Links | BibTeX | Tags: Aniline Compounds, Azo Compounds, Benzylamines, carbon, I2CT, Nanotubes, Raman, Spectrophotometry, Spectrum Analysis, Surface Properties, Team-Bianco
@article{menard-moyon_one-pot_2011,
title = {One-pot triple functionalization of carbon nanotubes},
author = {Cécilia Ménard-Moyon and Chiara Fabbro and Maurizio Prato and Alberto Bianco},
doi = {10.1002/chem.201003050},
issn = {1521-3765},
year = {2011},
date = {2011-03-01},
journal = {Chemistry (Weinheim an Der Bergstrasse, Germany)},
volume = {17},
number = {11},
pages = {3222--3227},
abstract = {Carbon nanotubes (CNTs) are very promising as carriers for the delivery of bioactive molecules. The multifunctionalization of CNTs is necessary to impart multimodalities for the development of future CNT-based multipotent therapeutic constructs. In this context, we report the first example of covalent trifunctionalization of different types of CNTs. Our strategy is a simple and efficient methodology based on the simultaneous functionalization of the nanotube surface with three different active groups. The reaction is performed in one step by arylation with diazonium salts generated in situ. The CNTs are functionalized with benzylamine moieties blocked with three different protecting groups that can be selectively removed under specific conditions. The trifunctionalized CNTs were characterized by TEM, thermogravimetric analysis, and Raman and UV/Vis/NIR spectroscopy, while the amine loading was determined by using the Kaiser test. The sequential removal of the protecting groups of the amine functions allows the grafting of the molecules of interest on the nanotube surface to be controlled.},
keywords = {Aniline Compounds, Azo Compounds, Benzylamines, carbon, I2CT, Nanotubes, Raman, Spectrophotometry, Spectrum Analysis, Surface Properties, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
2010
Samorì Cristian, Ali-Boucetta Hanene, Sainz Raquel, Guo Chang, Toma Francesca Maria, Fabbro Chiara, da Ros Tatiana, Prato Maurizio, Kostarelos Kostas, Bianco Alberto
Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers Journal Article
In: Chemical Communications (Cambridge, England), vol. 46, no. 9, pp. 1494–1496, 2010, ISSN: 1364-548X.
Abstract | Links | BibTeX | Tags: Antineoplastic Agents, Azo Compounds, carbon, Cell Line, Cross-Linking Reagents, Humans, I2CT, Methotrexate, Nanotubes, Team-Bianco, Thiosemicarbazones, tumor
@article{samori_enhanced_2010,
title = {Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers},
author = {Cristian Samorì and Hanene Ali-Boucetta and Raquel Sainz and Chang Guo and Francesca Maria Toma and Chiara Fabbro and Tatiana da Ros and Maurizio Prato and Kostas Kostarelos and Alberto Bianco},
doi = {10.1039/b923560d},
issn = {1364-548X},
year = {2010},
date = {2010-03-01},
journal = {Chemical Communications (Cambridge, England)},
volume = {46},
number = {9},
pages = {1494--1496},
abstract = {Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.},
keywords = {Antineoplastic Agents, Azo Compounds, carbon, Cell Line, Cross-Linking Reagents, Humans, I2CT, Methotrexate, Nanotubes, Team-Bianco, Thiosemicarbazones, tumor},
pubstate = {published},
tppubtype = {article}
}
2009
Herrero Antonia M, Toma Francesca M, Al-Jamal Khuloud T, Kostarelos Kostas, Bianco Alberto, Ros Tatiana Da, Bano Fouzia, Casalis Loredana, Scoles Giacinto, Prato Maurizio
Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery Journal Article
In: Journal of the American Chemical Society, vol. 131, no. 28, pp. 9843–9848, 2009, ISSN: 1520-5126.
Abstract | Links | BibTeX | Tags: Acrylates, Animals, Azo Compounds, Biological Transport, carbon, Cytoplasm, Dendrimers, Drug Carriers, Ethylenediamines, Gene Silencing, HeLa Cells, Humans, I2CT, Nanotubes, Polyamines, RNA, Small Interfering, Solubility, Team-Bianco, Thiosemicarbazones, Transfection, water
@article{herrero_synthesis_2009,
title = {Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery},
author = {Antonia M Herrero and Francesca M Toma and Khuloud T Al-Jamal and Kostas Kostarelos and Alberto Bianco and Tatiana Da Ros and Fouzia Bano and Loredana Casalis and Giacinto Scoles and Maurizio Prato},
doi = {10.1021/ja903316z},
issn = {1520-5126},
year = {2009},
date = {2009-07-01},
journal = {Journal of the American Chemical Society},
volume = {131},
number = {28},
pages = {9843--9848},
abstract = {A new series of dendron-functionalized multiwalled carbon nanotube (MWNT) derivatives, characterized by the presence of numerous positively charged tetraalkyl ammonium salts at the periphery of the dendron, has been synthesized. The positive charges on the MWNT surface, coupled with the unique ability of carbon nanotubes (CNTs) to penetrate cell membranes, make the new derivatives potentially ideal vectors for siRNA delivery. Using a fluorescently labeled, noncoding siRNA sequence, we demonstrate that cytoplasmic delivery of the nucleic acid is remarkably increased throughout the different dendron generations. The work reported here highlights the fact that dendron-functionalized CNTs can be rationally designed as efficient carriers of siRNA that can eventually lead to gene silencing.},
keywords = {Acrylates, Animals, Azo Compounds, Biological Transport, carbon, Cytoplasm, Dendrimers, Drug Carriers, Ethylenediamines, Gene Silencing, HeLa Cells, Humans, I2CT, Nanotubes, Polyamines, RNA, Small Interfering, Solubility, Team-Bianco, Thiosemicarbazones, Transfection, water},
pubstate = {published},
tppubtype = {article}
}
2006
Pastorin Giorgia, Wu Wei, Wieckowski Sébastien, Briand Jean-Paul, Kostarelos Kostas, Prato Maurizio, Bianco Alberto
Double functionalization of carbon nanotubes for multimodal drug delivery Journal Article
In: Chemical Communications (Cambridge, England), no. 11, pp. 1182–1184, 2006, ISSN: 1359-7345.
Abstract | Links | BibTeX | Tags: Azo Compounds, carbon, Cyclization, Drug Carriers, I2CT, Microscopy, Nanotubes, Pharmaceutical Preparations, Scanning Tunneling, Solubility, Team-Bianco
@article{pastorin_double_2006,
title = {Double functionalization of carbon nanotubes for multimodal drug delivery},
author = {Giorgia Pastorin and Wei Wu and Sébastien Wieckowski and Jean-Paul Briand and Kostas Kostarelos and Maurizio Prato and Alberto Bianco},
doi = {10.1039/b516309a},
issn = {1359-7345},
year = {2006},
date = {2006-03-01},
journal = {Chemical Communications (Cambridge, England)},
number = {11},
pages = {1182--1184},
abstract = {Multi-walled carbon nanotubes have been covalently functionalized via 1,3-dipolar cycloaddition of azomethine ylides with orthogonally protected amino functions that can be selectively deprotected and subsequently modified with drugs and fluorescent probes.},
keywords = {Azo Compounds, carbon, Cyclization, Drug Carriers, I2CT, Microscopy, Nanotubes, Pharmaceutical Preparations, Scanning Tunneling, Solubility, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}