Publications
2019
Lucherelli Matteo Andrea, Raya Jésus, Edelthalhammer Konstantin F, Hauke Frank, Hirsch Andreas, Abellán Gonzalo, Bianco Alberto
A Straightforward Approach to Multifunctional Graphene Journal Article
In: Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 25, no. 57, pp. 13218–13223, 2019, ISSN: 1521-3765.
Abstract | Links | BibTeX | Tags: carbon materials, diazonium salts, Functionalization, Graphite, I2CT, orthogonal protection, Team-Bianco
@article{lucherelli_straightforward_2019,
title = {A Straightforward Approach to Multifunctional Graphene},
author = {Matteo Andrea Lucherelli and Jésus Raya and Konstantin F Edelthalhammer and Frank Hauke and Andreas Hirsch and Gonzalo Abellán and Alberto Bianco},
doi = {10.1002/chem.201903165},
issn = {1521-3765},
year = {2019},
date = {2019-01-01},
journal = {Chemistry (Weinheim an Der Bergstrasse, Germany)},
volume = {25},
number = {57},
pages = {13218--13223},
abstract = {Graphene has been covalently functionalized through a one-pot reductive pathway using graphite intercalation compounds (GICs), in particular KC8 , with three different orthogonally protected derivatives of 4-aminobenzylamine. This novel multifunctional platform exhibits excellent bulk functionalization homogeneity (Hbulk ) and degree of addition while preserving the chemical functionalities of the organic addends through different protecting groups, namely: tert-butyloxycarbonyl (Boc), benzyloxycarbonyl (Cbz) and phthalimide (Pht). We have employed (temperature-dependent) statistical Raman spectroscopy (SRS), X-ray photoelectron spectroscopy (XPS), magic angle spinning solid state 13 C NMR (MAS-NMR), and a characterization tool consisting of thermogravimetric analysis coupled with gas chromatography and mass spectrometry (TG-GC-MS) to unambiguously demonstrate the covalent binding and the chemical nature of the different molecular linkers. This work paves the way for the development of smart graphene-based materials of great interest in biomedicine or electronics, to name a few, and will serve as a guide in the design of new 2D multifunctional materials.},
keywords = {carbon materials, diazonium salts, Functionalization, Graphite, I2CT, orthogonal protection, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}
Reina Giacomo, Zhao Li, Bianco Alberto, Komatsu Naoki
Chemical Functionalization of Nanodiamonds: Opportunities and Challenges Ahead Journal Article
In: Angewandte Chemie International Edition, vol. 58, no. 50, pp. 17918–17929, 2019, ISSN: 1521-3773.
Abstract | Links | BibTeX | Tags: carbon materials, diamond, Functionalization, I2CT, imaging, Team-Bianco, therapy
@article{reina_chemical_2019,
title = {Chemical Functionalization of Nanodiamonds: Opportunities and Challenges Ahead},
author = {Giacomo Reina and Li Zhao and Alberto Bianco and Naoki Komatsu},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201905997},
doi = {10.1002/anie.201905997},
issn = {1521-3773},
year = {2019},
date = {2019-01-01},
urldate = {2020-04-01},
journal = {Angewandte Chemie International Edition},
volume = {58},
number = {50},
pages = {17918--17929},
abstract = {Nanodiamond(ND)-based technologies are flourishing in a wide variety of fields spanning from electronics and optics to biomedicine. NDs are considered a family of nanomaterials with an sp3 carbon core and a variety of sizes, shapes, and surfaces. They show interesting physicochemical properties such as hardness, stiffness, and chemical stability. Additionally, they can undergo ad-hoc core and surface functionalization, which tailors them for the desired applications. Noteworthy, the properties of NDs and their surface chemistry are highly dependent on the synthetic method used to prepare them. In this Minireview, we describe the preparation of NDs from the materials-chemistry viewpoint. The different methodologies of synthesis, purification, and surface functionalization as well as biomedical applications are critically discussed. New synthetic approaches as well as limits and obstacles of NDs are presented and analyzed.},
keywords = {carbon materials, diamond, Functionalization, I2CT, imaging, Team-Bianco, therapy},
pubstate = {published},
tppubtype = {article}
}
2013
Dumortier Hélène
When carbon nanotubes encounter the immune system: desirable and undesirable effects Journal Article
In: Advanced Drug Delivery Reviews, vol. 65, no. 15, pp. 2120–2126, 2013, ISSN: 1872-8294.
Abstract | Links | BibTeX | Tags: Animals, Biomedical application, carbon, Carbon nanotubes, Dumortier, Environmental Exposure, Functionalization, Humans, I2CT, Immune cell activation, Immune System, inflammation, Inhalation Exposure, Lymphocyte, Macrophage, Nanotubes, Occupational Exposure, Team-Dumortier, Toxicity
@article{dumortier_when_2013,
title = {When carbon nanotubes encounter the immune system: desirable and undesirable effects},
author = {Hélène Dumortier},
doi = {10.1016/j.addr.2013.09.005},
issn = {1872-8294},
year = {2013},
date = {2013-01-01},
journal = {Advanced Drug Delivery Reviews},
volume = {65},
number = {15},
pages = {2120--2126},
abstract = {The role of our immune system is to bring efficient protection against invasion by foreign elements, not only pathogens but also any material it may be in contact with. Nanoparticles may enter the body and encounter the immune system either intentionally (e.g. administration for biomedical application) or not (e.g. respiratory occupational exposure). Therefore, it is of fundamental importance to get a thorough knowledge of the way they interact with immune cells and all related consequences. Among nanomaterials, carbon nanotubes (CNTs) are of special interest because of their tremendous field of applications. Consequently, their increasing production, processing and eventual incorporation into new types of composites and/or into biological systems have raised fundamental issues regarding their potential impact on health. This review aims at giving an overview of the known desirable and undesirable effects of CNTs on the immune system, i.e. beneficial modulation of immune cells by CNTs engineered for biomedical applications versus toxicity, inflammation and unwanted immune reactions triggered by CNTs themselves.},
keywords = {Animals, Biomedical application, carbon, Carbon nanotubes, Dumortier, Environmental Exposure, Functionalization, Humans, I2CT, Immune cell activation, Immune System, inflammation, Inhalation Exposure, Lymphocyte, Macrophage, Nanotubes, Occupational Exposure, Team-Dumortier, Toxicity},
pubstate = {published},
tppubtype = {article}
}
2006
Campidelli Stéphane, Klumpp Cédric, Bianco Alberto, Guldi Dirk M, Prato Maurizio
Functionalization of CNT: synthesis and applications in photovoltaics and biology Journal Article
In: Journal of Physical Organic Chemistry, vol. 19, no. 8-9, pp. 531–539, 2006, ISSN: 1099-1395.
Abstract | Links | BibTeX | Tags: Carbon nanotubes, Cells, Drug delivery, electron transfer, Functionalization, I2CT, Peptides, photovoltaic, Team-Bianco, Toxicity, Vectors
@article{campidelli_functionalization_2006,
title = {Functionalization of CNT: synthesis and applications in photovoltaics and biology},
author = {Stéphane Campidelli and Cédric Klumpp and Alberto Bianco and Dirk M Guldi and Maurizio Prato},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/poc.1052},
doi = {10.1002/poc.1052},
issn = {1099-1395},
year = {2006},
date = {2006-01-01},
urldate = {2020-03-31},
journal = {Journal of Physical Organic Chemistry},
volume = {19},
number = {8-9},
pages = {531--539},
abstract = {Here, we review part of the work carried out in our laboratories on carbon nanotube functionalization. Both covalent (sidewall derivatization) and non-covalent (using π-π interactions) functionalization have been used to solubilize carbon nanotubes (NTs). The combination of NTs with various electron donors, mainly using the supramolecular approach, led to a new generation of donor-acceptor nanohybrids which can be used for the development of carbon-based photovoltaic cells. Covalent functionalization has been successfully applied for preparation of water soluble nanotubes and further derivatization of the nanotubes with bioactive molecules hold great promise for application in drug, vaccine and gene delivery. Copyright © 2006 John Wiley & Sons, Ltd.},
keywords = {Carbon nanotubes, Cells, Drug delivery, electron transfer, Functionalization, I2CT, Peptides, photovoltaic, Team-Bianco, Toxicity, Vectors},
pubstate = {published},
tppubtype = {article}
}
2003
Bianco A, Prato M
Can Carbon Nanotubes be Considered Useful Tools for Biological Applications? Journal Article
In: Advanced Materials, vol. 15, no. 20, pp. 1765–1768, 2003, ISSN: 1521-4095.
Abstract | Links | BibTeX | Tags: Carbon nanotubes, Functionalization, I2CT, Team-Bianco
@article{bianco_can_2003,
title = {Can Carbon Nanotubes be Considered Useful Tools for Biological Applications?},
author = {A Bianco and M Prato},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.200301646},
doi = {10.1002/adma.200301646},
issn = {1521-4095},
year = {2003},
date = {2003-01-01},
urldate = {2020-03-31},
journal = {Advanced Materials},
volume = {15},
number = {20},
pages = {1765--1768},
abstract = {Carbon nanotubes can be made soluble in both organic solvents and in aqueous solutions by organic functionalization. In particular, soluble carbon nanotubes can be further derivatized by coupling with amino acids and bioactive peptides. Immobilization of peptides to the external walls of carbon nanotubes may find interesting applications in diagnostics, vaccine and drug delivery, or multipresentation of bioactive molecules.},
keywords = {Carbon nanotubes, Functionalization, I2CT, Team-Bianco},
pubstate = {published},
tppubtype = {article}
}