Publications
2000
Zenkova M A, Vlasov A V, Konevets D A, Sil'nikov V N, Giege R, Vlasov V V
[Chemical ribonucleases. 2. Design and hydrolytic properties RNase mimetics based on diazabicyclo[2.2.2]octane with various positive charges] Journal Article
In: Bioorg Khim, vol. 26, no. 9, pp. 679-685, 2000, ISBN: 11036527, (0132-3423 Journal Article).
Abstract | Links | BibTeX | Tags: Bicyclo Compounds, Heterocyclic/*chemical synthesis/chemistry Catalysis Cations, Lys/chemistry/genetics Ribonucleases/*chemistry Structure-Activity Relationship, Monovalent/chemistry Drug Design English Abstract Human Hydrolysis Imidazoles/*chemical synthesis/chemistry Magnesium/chemistry Mitochondria/chemistry Molecular Mimicry Point Mutation RNA, Transfer, Unité ARN
@article{,
title = {[Chemical ribonucleases. 2. Design and hydrolytic properties RNase mimetics based on diazabicyclo[2.2.2]octane with various positive charges]},
author = {M A Zenkova and A V Vlasov and D A Konevets and V N Sil'nikov and R Giege and V V Vlasov},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11036527},
isbn = {11036527},
year = {2000},
date = {2000-01-01},
journal = {Bioorg Khim},
volume = {26},
number = {9},
pages = {679-685},
abstract = {A procedure was proposed allowing one to synthesize RNA mimics on the basis of conjugates of diazabicyclo[2.2.2]octane with imidazole bearing a varying number of positive charges (nDm series, where n is the number of positive charges at neutral pH, m is the code of an imidazole-containing fragment of the catalytic domain: 1, histamine; 2, histidine methyl ester). The hydrolytic activity of six compounds of this series was studied under physiological conditions using in vitro transcript of human mitochondrial tRNA(Lys) as a substrate. It was shown that the rate of RNA hydrolysis with nDm conjugates rises with an increase in the number of positive charges: an approximately 30-fold acceleration of hydrolysis was observed with an increase in the total charge of the construct from +2 to +4.},
note = {0132-3423
Journal Article},
keywords = {Bicyclo Compounds, Heterocyclic/*chemical synthesis/chemistry Catalysis Cations, Lys/chemistry/genetics Ribonucleases/*chemistry Structure-Activity Relationship, Monovalent/chemistry Drug Design English Abstract Human Hydrolysis Imidazoles/*chemical synthesis/chemistry Magnesium/chemistry Mitochondria/chemistry Molecular Mimicry Point Mutation RNA, Transfer, Unité ARN},
pubstate = {published},
tppubtype = {article}
}