Imaging

@article{,

title = {[Chemical ribonucleases. 2. Design and hydrolytic properties RNase mimetics based on diazabicyclo[2.2.2]octane with various positive charges]},

author = {M A Zenkova and A V Vlasov and D A Konevets and V N Sil'nikov and R Giege and V V Vlasov},

url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11036527},

isbn = {11036527},

year  = {2000},

date = {2000-01-01},

journal = {Bioorg Khim},

volume = {26},

number = {9},

pages = {679-685},

abstract = {A procedure was proposed allowing one to synthesize RNA mimics on the basis of conjugates of diazabicyclo[2.2.2]octane with imidazole bearing a varying number of positive charges (nDm series, where n is the number of positive charges at neutral pH, m is the code of an imidazole-containing fragment of the catalytic domain: 1, histamine; 2, histidine methyl ester). The hydrolytic activity of six compounds of this series was studied under physiological conditions using in vitro transcript of human mitochondrial tRNA(Lys) as a substrate. It was shown that the rate of RNA hydrolysis with nDm conjugates rises with an increase in the number of positive charges: an approximately 30-fold acceleration of hydrolysis was observed with an increase in the total charge of the construct from +2 to +4.},

note = {0132-3423 

Journal Article},

keywords = {Bicyclo Compounds, Heterocyclic/*chemical synthesis/chemistry  Catalysis  Cations, Lys/chemistry/genetics  Ribonucleases/*chemistry  Structure-Activity Relationship, Monovalent/chemistry  Drug Design  English Abstract  Human  Hydrolysis  Imidazoles/*chemical synthesis/chemistry  Magnesium/chemistry  Mitochondria/chemistry  Molecular Mimicry  Point Mutation  RNA, Transfer, Unité ARN},

pubstate = {published},

tppubtype = {article}

}