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2019

González-Serrano L E, Chihade J W, Sissler M

When a common biological role does not imply common disease outcomes: Disparate pathology linked to human mitochondrial aminoacyl-tRNA synthetases Journal Article

In: J Biol Chem, vol. 294, no. 14, pp. 5309-5320, 2019, ISBN: 30647134.

Abstract | Links | BibTeX | Tags: aminoacyl tRNA synthetase central nervous system (CNS) genetic disease mitochondria mutant, SISSLER, Unité ARN

2018

Hosseini M, Roy P, Sissler M, Zirbel C L, Westhof E, Leontis N

How to fold and protect mitochondrial ribosomal RNA with fewer guanines Journal Article

In: Nucleic Acids Res, vol. 46, no. 20, pp. 10946-10968, 2018, ISBN: 30215760.

Abstract | Links | BibTeX | Tags: SISSLER, Unité ARN, WESTHOF

González-Serrano L E, Karim L, Pierre F, Schwenzer H, Rotig A, Munnich A, Sissler M

Three human aminoacyl-tRNA synthetases have distinct sub-mitochondrial localizations that are unaffected by disease-associated mutations Journal Article

In: J Biol Chem, vol. 293, no. 35, pp. 13604-13615, 2018, ISBN: 30006346.

Abstract | Links | BibTeX | Tags: aminoacyl tRNA synthetase dual-localization human leukodystrophy membrane-anchored mitochondria mitochondrial disorder neurodegenerative disease pontocerebellar hypoplasia translation, SISSLER, Unité ARN

2017

Sissler M, González-Serrano L E, Westhof E

Recent Advances in Mitochondrial Aminoacyl-tRNA Synthetases and Disease Journal Article

In: Trends Mol Med, vol. 23, no. 8, pp. 693-708, 2017, ISBN: 28716624.

Abstract | Links | BibTeX | Tags: aminoacyl-tRNA synthetase central nervous system mitochondrial disease mitochondrial translation moonlighting proteins unfolded protein response, SISSLER, Unité ARN, WESTHOF

Moulinier L, Ripp R, Castillo G, Poch O, Sissler M

MiSynPat: an integrated knowledge base linking clinical, genetic, and structural data for disease-causing mutations in human mitochondrial aminoacyl-tRNA synthetases. Journal Article

In: Hum Mutat, vol. 38, no. 10, pp. 1316-1324, 2017, ISBN: 28608363.

Abstract | Links | BibTeX | Tags: 3D structures aminoacyl-tRNA synthetases disease-causing mutations knowledge base mitochondrial disorders sequence alignments, SISSLER, Unité ARN

Carapito C, Kuhn L, Karim L, Rompais M, Rabilloud T, Schwenzer H, Sissler M

Two proteomic methodologies for defining N-termini of mature human mitochondrial aminoacyl-tRNA synthetases. Journal Article

In: Methods, vol. 113, pp. 111-119, 2017, ISBN: 27793688.

Abstract | Links | BibTeX | Tags: PPSE, SISSLER, Unité ARN

2016

Sissler M

What is so special about neuronal translation? (comment on DOI 10.1002/bies.201600052). Journal Article

In: Bioessays, vol. 38, no. 9, pp. 816, 2016, ISBN: 27427507.

Links | BibTeX | Tags: SISSLER, Unité ARN

2015

Simon M, Richard E M, Wang X, Shahzad M, Huang V H, Qaiser T A, Potluri P, Mahl S E, Davila A, Nazli S, Hancock S, Yu M, Gargus J, Chang R, Al-Sheqaih N, Newman W G, Abdenur J, Starr A, Hegde R, Dorn T, Busch A, Park E, Wu J F, Schwenzer H, Flierl A, Florentz C, Sissler M, Khan S N, Li R, Guan M X, Friedman T B, Wu D K, Procaccio V, Riazuddin S, Wallace D C, Ahmed Z M, Huang T, Riazuddin S

Mutations of Human NARS2, Encoding the Mitochondrial Asparaginyl-tRNA Synthetase, Cause Nonsyndromic Deafness and Leigh Syndrome. Journal Article

In: PLoS Genet, vol. 11, no. 3, pp. e1005097, 2015, ISBN: 25807530.

Abstract | Links | BibTeX | Tags: FLORENTZ, SISSLER, Unité ARN

2014

Schwenzer H, Zoll J, Florentz C, Sissler M

Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases. Journal Article

In: Top Curr Chem, vol. 344, pp. 247-292, 2014, ISBN: 23824528.

Abstract | Links | BibTeX | Tags: Aminoacyl-tRNA synthetase Human mitochondrial disorders Pathology-related mutations Respiratory chain defects, FLORENTZ, SISSLER, Unité ARN

Schwenzer H, Scheper G C, Zorn N, Moulinier L, Gaudry A, Leize E, Martin F, Florentz C, Poch O, Sissler M

Released selective pressure on a structural domain gives new insights on the functional relaxation of mitochondrial aspartyl-tRNA synthetase. Journal Article

In: Biochimie, vol. 100, pp. 18-26, 2014, ISBN: 24120687.

Abstract | Links | BibTeX | Tags: Aminoacyl-tRNA synthetase Bioinformatics MTS Mitochondria Molecular biology Translation aaRS aminoacyl-tRNA synthetase (specificity is indicated by the name of the amino acid abbreviated in a three-letter code, e.g. AspRS stands for aspartyl-tRNA synthetase) mitochondrial mitochondrial targeting sequence mt, ERIANI, FLORENTZ, SISSLER, transferred to the cognate tRNA, Unité ARN

Maréchal-Drouard L, Sissler M, Tarassov I (Ed.)

Mitochondria: An organelle for life. Book

ELSEVIER, 2014.

BibTeX | Tags: SISSLER, Unité ARN

2012

Gaudry A, Lorber B, Neuenfeldt A, Sauter C, Florentz C, Sissler M

Re-designed N-terminus enhances expression, solubility and crystallizability of mitochondrial protein. Journal Article

In: Protein Eng Des Sel, vol. 25, no. 9, pp. 473-481, 2012, ISBN: 22871419.

Abstract | Links | BibTeX | Tags: FLORENTZ, FRUGIER, SISSLER, Unité ARN

Fender A, Gaudry A, Jühling F, Sissler M, Florentz C

Adaptation of aminoacylation identity rules to mammalian mitochondria. Journal Article

In: Biochimie, vol. 94, no. 5, pp. 1090-1097, 2012, ISBN: 22402012, (Available online 1 March 2012).

Abstract | Links | BibTeX | Tags: FLORENTZ, Identity elements Mitochondrial tRNA Cross-aminoacylation Structural plasticity, SISSLER, Unité ARN

2011

Messmer M, Florentz C, Schwenzer H, Scheper G C, van der Knaap M S, Marechal-Drouard L, Sissler M

A human pathology-related mutation prevents import of an aminoacyl-tRNA synthetase into mitochondria Journal Article

In: Biochem J, vol. 433, no. 3, pp. 441-446, 2011, ISSN: 1470-8728 (Electronic) 0264-6021 (Linking), (Messmer, Marie Florentz, Catherine Schwenzer, Hagen Scheper, Gert C van der Knaap, Marjo S Marechal-Drouard, Laurence Sissler, Marie Research Support, Non-U.S. Gov't England The Biochemical journal Biochem J. 2011 Jan 14;433(3):441-6.).

Abstract | Links | BibTeX | Tags: Aspartate-tRNA Ligase/*genetics/*metabolism Cell Line Humans Leukoencephalopathies/etiology/genetics Mitochondria/*metabolism *Mutation, FLORENTZ, Missense Protein Transport, SISSLER, Unité ARN

2009

Messmer M, Putz J, Suzuki T, Sauter C, Sissler M, Florentz C

Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny Journal Article

In: Nucleic Acids Res, vol. 37, no. 20, pp. 6881-6895, 2009, ISBN: 19767615, (1362-4962 (Electronic) 0305-1048 (Linking) Journal Article Research Support, Non-U.S. Gov't).

Abstract | Links | BibTeX | Tags: Asp/*chemistry/*metabolism Transcription, Base Sequence Databases, FLORENTZ, FRUGIER, Genetic, Nucleic Acid Humans Molecular Sequence Data Nucleic Acid Conformation Phylogeny RNA/*chemistry/*metabolism RNA, SISSLER, Transfer, Unité ARN

Messmer M, Gaudry A, Sissler M, Florentz C

Pathology-related mutation A7526G (A9G) helps in the understanding of the 3D structural core of human mitochondrial tRNA(Asp) Journal Article

In: RNA, vol. 15, no. 8, pp. 1462-1468, 2009, ISBN: 19535463, (1469-9001 (Electronic) Letter Research Support, Non-U.S. Gov't).

Abstract | Links | BibTeX | Tags: Asp/*chemistry/*genetics/metabolism Transfer RNA Aminoacylation/genetics, Binding Sites/genetics Humans Kinetics Mitochondrial Myopathies/genetics/metabolism/pathology Models, FLORENTZ, Missense Nucleic Acid Conformation RNA/*chemistry/*genetics/metabolism RNA, Molecular Mutation, SISSLER, Transfer, Unité ARN

Messmer M, Blais S P, Balg C, Chenevert R, Grenier L, Lague P, Sauter C, Sissler M, Giege R, Lapointe J, Florentz C

Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs Journal Article

In: Biochimie, vol. 91, no. 5, pp. 596-603, 2009, ISBN: 19254750, (1638-6183 (Electronic) Journal Article Research Support, Non-U.S. Gov't).

Abstract | Links | BibTeX | Tags: Adenosine Monophosphate/*analogs & derivatives/*pharmacology Animals Aspartate-tRNA Ligase/*antagonists & inhibitors/*chemistry/metabolism Catalytic Domain Cattle Humans Mitochondria/*drug effects/*enzymology Molecular Structure Structure-Activity Relationship, FLORENTZ, SISSLER, Unité ARN

2008

Sissler M, Lorber B, Messmer M, Schaller A, Putz J, Florentz C

Handling mammalian mitochondrial tRNAs and aminoacyl-tRNA synthetases for functional and structural characterization Journal Article

In: Methods, vol. 44, no. 2, pp. 176-189, 2008, ISBN: 18241799, (1046-2023 (Print) Journal article).

Abstract | Links | BibTeX | Tags: FLORENTZ, FLORENTZ GIEGE, SISSLER, Unité ARN

2007

Scheper G C, van der Klok T, van Andel R J, van Berkel C G, Sissler M, Smet J, Muravina T I, Serkov S V, Uziel G, Bugiani M, Schiffmann R, Krageloh-Mann I, Smeitink J A, Florentz C, Coster R Van, Pronk J C, van der Knaap M S

Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation Journal Article

In: Nat Genet, vol. 39, no. 4, pp. 534-539, 2007, ISBN: 17384640, (1061-4036 (Print) Journal Article).

Abstract | Links | BibTeX | Tags: FLORENTZ, SISSLER, Unité ARN

2006

Fender A, Sauter C, Messmer M, Putz J, Giege R, Florentz C, Sissler M

Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system Journal Article

In: J Biol Chem, vol. 281, no. 23, pp. 15980-15986, 2006, ISBN: 16597625, (0021-9258 (Print) Journal Article).

Abstract | Links | BibTeX | Tags: Acylation Base Sequence Humans Kinetics Mutagenesis Nucleic Acid Conformation Plasmids RNA | Non-U.S. Gov't, Asp/chemistry/genetics/*metabolism Research Support, FLORENTZ, FRUGIER, Non-U.S. Gov't, SISSLER, Transfer, Unité ARN

2005

Sissler M, Putz J, Fasiolo F, Florentz C

Mitochondrial aminoacyl-tRNA synthetases Book Chapter

In: Ibba, M; Francklyn, C; Cusak, S (Ed.): The Aminoacyl-tRNA Synthetases, Landes Bioscience, 2005.

Abstract | Links | BibTeX | Tags: FLORENTZ, FLORENTZ FASIOLO, SISSLER, Unité ARN

Champagne K S, Sissler M, Larrabee Y, Doublie S, Francklyn C S

Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog Journal Article

In: J Biol Chem, vol. 280, no. 40, pp. 34096-34104, 2005, ISBN: 16051603, (0021-9258 (Print) Journal Article).

Abstract | Links | BibTeX | Tags: Extramural Research Support, FLORENTZ ATP Phosphoribosyltransferase/*metabolism Allosteric Regulation Amino Acyl-tRNA Synthetases DNA Mutational Analysis Enzyme Activation *Models, N.I.H., Non-P.H.S. Research Support, P.H.S., SISSLER, Structural Phosphates/metabolism Research Support, U.S. Gov't, Unité ARN

Bonnefond L, Fender A, Rudinger-Thirion J, Giege R, Florentz C, Sissler M

Toward the Full Set of Human Mitochondrial Aminoacyl-tRNA Synthetases: Characterization of AspRS and TyrRS Journal Article

In: Biochemistry, vol. 44, no. 12, pp. 4805-4816, 2005, ISBN: 15779907, (0006-2960 Journal Article).

Abstract | Links | BibTeX | Tags: FLORENTZ, FRUGIER, SISSLER, Unité ARN

2004

Sohm B, Sissler M, Park H, King M P, Florentz C

Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase Journal Article

In: J Mol Biol, vol. 339, no. 1, pp. 17-29, 2004, ISBN: 15123417, (0022-2836 Journal Article).

Abstract | Links | BibTeX | Tags: Cultured, FLORENTZ, FLORENTZ *Acylation Base Sequence Comparative Study Human Kinetics Leucine/metabolism Leucine-tRNA Ligase/genetics/*metabolism Mitochondria/*metabolism Molecular Sequence Data Mutation Nucleic Acid Conformation Osteosarcoma/metabolism RNA/*genetics/metabolism RNA, Genetic/*genetics Tumor Cells, Leu/genetics/*metabolism Solutions Substrate Specificity Support, Non-U.S. Gov't Support, P.H.S. Transcription, SISSLER, Transfer, U.S. Gov't, Unité ARN

Sissler M, Helm M, Frugier M, Giege R, Florentz C

Aminoacylation properties of pathology-related human mitochondrial tRNA(Lys) variants Journal Article

In: RNA, vol. 10, no. 5, pp. 841-853, 2004, ISBN: 15100439, (1355-8382 Journal Article).

Abstract | Links | BibTeX | Tags: ERIANI, FLORENTZ, FLORENTZ GIEGE Acylation Aminoacyltransferases/*genetics Human MERRF Syndrome/genetics Mitochondria/*genetics Mitochondrial Diseases/*genetics Mutation Nucleic Acid Conformation RNA, FRUGIER, Lys/*genetics Sequence Analysis, Non-U.S. Gov't Variation (Genetics), RNA Support, SISSLER, Transfer, Unité ARN

Fender A, Sissler M, Florentz C, Giege R

Functional idiosyncrasies of tRNA isoacceptors in cognate and noncognate aminoacylation systems Journal Article

In: Biochimie, vol. 86, no. 1, pp. 21-29, 2004, ISBN: 14987797, (0300-9084 Journal Article).

Abstract | Links | BibTeX | Tags: Amino Acyl/genetics/*metabolism Saccharomyces cerevisiae Substrate Specificity/genetics/physiology Support, Chemical Molecular Sequence Data Mutation Nucleic Acid Conformation Protein Binding/physiology RNA, FLORENTZ, GIEGE FLORENTZ Amino Acid Activation/physiology Amino Acyl-tRNA Ligases/*metabolism Anticodon Bacterial Proteins/metabolism Base Sequence Cloning, Molecular Computer Simulation Escherichia coli Models, Non-U.S. Gov't Thermus thermophilus, SISSLER, Transfer, Transfer/genetics/*metabolism RNA, Unité ARN

Fender A, Geslain R, Eriani G, Giege R, Sissler M, Florentz C

A yeast arginine specific tRNA is a remnant aspartate acceptor Journal Article

In: Nucleic Acids Res, vol. 32, no. 17, pp. 5076-5086, 2004, ISBN: 15452274, (1362-4962 Journal Article).

Abstract | Links | BibTeX | Tags: Arg/*chemistry/genetics/metabolism RNA, Asp/*chemistry/genetics/metabolism Saccharomyces cerevisiae/*genetics Sequence Alignment Support, ERIANI, ERIANI FLORENTZ GIEGE Aspartic Acid/metabolism Base Sequence *Evolution, FLORENTZ, Fungal/*chemistry/genetics/metabolism RNA, Molecular Molecular Sequence Data Point Mutation RNA, Non-U.S. Gov't, SISSLER, Transfer, Unité ARN

2003

Florentz C, Sohm B, Tryoen-Toth P, Putz J, Sissler M

Human mitochondrial tRNAs in health and disease Journal Article

In: Cell Mol Life Sci, vol. 60, no. 7, pp. 1356-1375, 2003, ISBN: 12943225, (1420-682x Journal Article Review Review, Academic).

Abstract | Links | BibTeX | Tags: Base Sequence Genetic Diseases, FLORENTZ, Genetic, Inborn/*genetics Genome Human Mitochondria/*genetics Molecular Sequence Data Nucleic Acid Conformation RNA/chemistry/*genetics RNA, Messenger/genetics/metabolism RNA, Non-U.S. Gov't Translation, SISSLER, Transfer/chemistry/*genetics Reference Values Support, Unité ARN

Florentz C, Sissler M

Mitochondrial tRNA aminoacylation and human diseases. Book Chapter

In: Lapointe, J; Brakier-Gringas, L (Ed.): Translation Mechanisms, pp. 129-143, Landes Bioscience, 2003.

Abstract | Links | BibTeX | Tags: FLORENTZ, SISSLER, Unité ARN

1997

Sissler M, Eriani G, Martin F, Giege R, Florentz C

Mirror image alternative interaction patterns of the same tRNA with either class I arginyl-tRNA synthetase or class II aspartyl-tRNA synthetase Journal Article

In: Nucleic Acids Res, vol. 25, no. 24, pp. 4899-4906, 1997, ISBN: 9396794, (0305-1048 Journal Article).

Abstract | Links | BibTeX | Tags: Anticodon/chemistry Arginine-tRNA Ligase/classification/*metabolism Aspartate-tRNA Ligase/classification/*metabolism Base Sequence DNA Footprinting Escherichia coli Fungal Proteins/classification/*metabolism Models, Arg/chemistry/*metabolism RNA, Asp/chemistry/*metabolism Recombinant Fusion Proteins/metabolism Saccharomyces cerevisiae/metabolism Stereoisomerism Substrate Specificity Support, ERIANI, FLORENTZ, Fungal/chemistry/*metabolism RNA, Molecular Molecular Sequence Data *Nucleic Acid Conformation Protein Binding RNA, Non-U.S. Gov't, SISSLER, Transfer, Unité ARN

Putz J, Wientges J, Sissler M, Giege R, Florentz C, Schwienhorst A

Rapid selection of aminoacyl-tRNAs based on biotinylation of alpha-NH2 group of charged amino acids Journal Article

In: Nucleic Acids Res, vol. 25, no. 9, pp. 1862-1863, 1997, ISBN: 9162902, (0305-1048 Journal Article).

Abstract | Links | BibTeX | Tags: Amino Acids/*chemistry Biotin/*chemistry Polymerase Chain Reaction RNA, Amino Acyl/chemistry/*isolation & purification Support, FLORENTZ, Non-U.S. Gov't, SISSLER, Transfer, Unité ARN

Becker H F, Motorin Y, Sissler M, Florentz C, Grosjean H

Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T psi-loop of yeast tRNAs Journal Article

In: J Mol Biol, vol. 274, no. 4, pp. 505-518, 1997, ISBN: 9417931, (0022-2836 Journal Article).

Abstract | Links | BibTeX | Tags: Asp/chemistry/metabolism Saccharomyces cerevisiae/genetics Substrate Specificity Support, Base Sequence Conserved Sequence Intramolecular Lyases/metabolism Models, FLORENTZ, Fungal/*chemistry/metabolism RNA, Molecular Molecular Sequence Data Nucleic Acid Conformation Pseudouridine/chemistry/*metabolism RNA, Non-U.S. Gov't Uridine/*analogs & derivatives/chemistry/metabolism tRNA Methyltransferases/metabolism, SISSLER, Transfer, Transfer/*chemistry/*metabolism RNA, Unité ARN

1996

Sissler M, Giege R, Florentz C

Arginine aminoacylation identity is context-dependent and ensured by alternate recognition sets in the anticodon loop of accepting tRNA transcripts Journal Article

In: EMBO J, vol. 15, no. 18, pp. 5069-5076, 1996, ISBN: 8890180, (0261-4189 Journal Article).

Abstract | Links | BibTeX | Tags: *Anticodon Arginine/*metabolism Base Sequence Kinetics Molecular Sequence Data Nucleic Acid Conformation RNA, Arg/*chemistry/metabolism RNA, Asp/chemistry/metabolism Saccharomyces cerevisiae Support, FLORENTZ, Fungal/*chemistry/metabolism RNA, Non-U.S. Gov't, SISSLER, Transfer, Unité ARN