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Leclerc Vincent, Pelte Nadège, Chamy Laure El, Martinelli Cosimo, Ligoxygakis Petros, Hoffmann Jules A, Reichhart Jean-Marc

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila Journal Article

In: EMBO Rep., vol. 7, no. 2, pp. 231–235, 2006, ISSN: 1469-221X.

Abstract | Links | BibTeX | Tags: Animals, Bacterial Infections, Catechol Oxidase, Enzyme Activation, Enzyme Precursors, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, hoffmann, Immunity, Innate, M3i, Mutation, reichhart, Survival Rate


Gobert Vanessa, Gottar Marie, Matskevich Alexey A, Rutschmann Sophie, Royet Julien, Belvin Marcia, Hoffmann Jules A, Ferrandon Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Journal Article

In: Science, vol. 302, no. 5653, pp. 2126–2130, 2003, ISSN: 1095-9203.

Abstract | Links | BibTeX | Tags: Animals, Carrier Proteins, Cell Surface, DNA Transposable Elements, ferrandon, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, hoffmann, Hypocreales, Insect, Insect Proteins, M3i, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

Bilak Hana, Tauszig-Delamasure S, Imler Jean-Luc

Toll and Toll-like receptors in Drosophila Journal Article

In: Biochemical Society Transactions, vol. 31, no. Pt 3, pp. 648–651, 2003, ISSN: 0300-5127.

Abstract | Links | BibTeX | Tags: Animals, Biological Evolution, Cell Surface, Fungi, Genome, Gram-Negative Bacteria, Gram-Positive Bacteria, imler, M3i, Membrane Glycoproteins, Receptors, Toll-Like Receptor 5, Toll-Like Receptors


Tauszig-Delamasure Servane, Bilak Hana, Capovilla Maria, Hoffmann Jules A, Imler Jean-Luc

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections Journal Article

In: Nature Immunology, vol. 3, no. 1, pp. 91–97, 2002, ISSN: 1529-2908.

Abstract | Links | BibTeX | Tags: Adaptor Proteins, Amino Acid, Animals, Antigens, Antimicrobial Cationic Peptides, Cell Surface, Chromosome Mapping, Differentiation, Disease Susceptibility, Enterococcus faecalis, Epistasis, Escherichia coli, Female, Gene Expression Regulation, Genes, Genetic, Genetically Modified, Gram-Negative Bacteria, hoffmann, Hypocreales, imler, Immunologic, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Myeloid Differentiation Factor 88, Protein Structure, Protein-Serine-Threonine Kinases, Receptors, Recombinant Fusion Proteins, Sequence Alignment, Sequence Homology, Signal Transducing, Tertiary, Toll-Like Receptors, Transfection

Imler Jean-Luc, Hoffmann Jules A

Toll receptors in Drosophila: a family of molecules regulating development and immunity Journal Article

In: Current Topics in Microbiology and Immunology, vol. 270, pp. 63–79, 2002, ISSN: 0070-217X.

Abstract | BibTeX | Tags: Animals, Cell Surface, Genetic, Gram-Negative Bacteria, hoffmann, imler, M3i, Receptors, Signal Transduction, Toll-Like Receptors, Transcription


Irving Phil, Troxler Laurent, Heuer Timothy S, Belvin Marcia, Kopczynski Casey, Reichhart Jean-Marc, Hoffmann Jules A, Hetru Charles

A genome-wide analysis of immune responses in Drosophila Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 98, no. 26, pp. 15119–15124, 2001, ISSN: 0027-8424.

Abstract | Links | BibTeX | Tags: Animals, bioinformatic, Gene Expression Regulation, Genome, Gram-Negative Bacteria, hoffmann, M3i, Male, Oligonucleotide Array Sequence Analysis, reichhart, Signal Transduction

Levashina Elena A, Moita L F, Blandin Stéphanie A, Vriend G, Lagueux Marie, Kafatos F C

Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae Journal Article

In: Cell, vol. 104, no. 5, pp. 709–718, 2001, ISSN: 0092-8674.

Abstract | BibTeX | Tags: alpha-Macroglobulins, Animals, Anopheles, blandin, Cells, Cloning, Complement C3, Cultured, DNA Fragmentation, Double-Stranded, Female, Genetic, Gram-Negative Bacteria, Hemocytes, Insect Proteins, M3i, Molecular, Nucleic Acid Denaturation, Phagocytosis, Protein Structure, RNA, Tertiary, Transcription


Hetru Charles, Letellier L, Oren Z, Hoffmann Jules A, Shai Y

Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action Journal Article

In: Biochem. J., vol. 345 Pt 3, pp. 653–664, 2000, ISSN: 0264-6021.

Abstract | BibTeX | Tags: Adenosine Triphosphate, Anti-Bacterial Agents, Cations, Cell Membrane Permeability, Cytoplasm, Disulfides, Electron, Escherichia coli, Fluoresceins, Fluorescent Dyes, Fourier Transform Infrared, Gram-Negative Bacteria, hoffmann, Insect Proteins, Liposomes, M3i, Microbial Sensitivity Tests, Micrococcus luteus, Microscopy, oxygen, Phospholipids, Potassium, Proteins, spectroscopy


Fehlbaum P, Bulet Philippe, Chernysh S, Briand J P, Roussel J P, Letellier L, Hetru Charles, Hoffmann Jules A

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 93, no. 3, pp. 1221–1225, 1996, ISSN: 0027-8424.

Abstract | BibTeX | Tags: Amino Acid, Amphibian Proteins, Animals, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Cyclic, Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, hoffmann, M3i, Mass Spectrometry, Microbial Sensitivity Tests, Peptides, Ranidae, Sequence Homology, Skin, Structure-Activity Relationship


Lowenberger C, Bulet Philippe, Charlet Maurice, Hetru Charles, Hodgeman B, Christensen B M, Hoffmann Jules A

Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti Journal Article

In: Insect Biochem. Mol. Biol., vol. 25, no. 7, pp. 867–873, 1995, ISSN: 0965-1748.

Abstract | BibTeX | Tags: Aedes, Amino Acid, Animals, Anti-Bacterial Agents, Blood Proteins, Defensins, Escherichia coli, Gram-Negative Bacteria, Gram-Positive Bacteria, hoffmann, Immunity, Insect Vectors, M3i, Micrococcus luteus, Sequence Homology, Stereoisomerism


Cociancich S, Dupont A, Hegy G, Lanot R, Holder F, Hetru Charles, Hoffmann Jules A, Bulet Philippe

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus Journal Article

In: Biochem. J., vol. 300 ( Pt 2), pp. 567–575, 1994, ISSN: 0264-6021.

Abstract | BibTeX | Tags: Amino Acid, Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Proteins, Chromatography, Defensins, Gas Chromatography-Mass Spectrometry, Gel, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Hemolymph, hoffmann, Insect Proteins, M3i, Peptides, Sequence Homology