Publications
2014
Lamiable Olivier, Imler Jean-Luc
Induced antiviral innate immunity in Drosophila Journal Article
In: Current Opinion in Microbiology, vol. 20, pp. 62–68, 2014, ISSN: 1879-0364.
Abstract | Links | BibTeX | Tags: Animals, Gene Expression Regulation, Host-Pathogen Interactions, imler, Immunity, Innate, M3i, RNA Viruses, Signal Transduction
@article{lamiable_induced_2014,
title = {Induced antiviral innate immunity in Drosophila},
author = {Olivier Lamiable and Jean-Luc Imler},
doi = {10.1016/j.mib.2014.05.006},
issn = {1879-0364},
year = {2014},
date = {2014-08-01},
journal = {Current Opinion in Microbiology},
volume = {20},
pages = {62--68},
abstract = {Immunity to viral infections in the model organism Drosophila melanogaster involves both RNA interference and additional induced responses. The latter include not only cellular mechanisms such as programmed cell death and autophagy, but also the induction of a large set of genes, some of which contribute to the control of viral replication and resistance to infection. This induced response to infection is complex and involves both virus-specific and cell-type specific mechanisms. We review here recent developments, from the sensing of viral infection to the induction of signaling pathways and production of antiviral effector molecules. Our current understanding, although still partial, validates the Drosophila model of antiviral induced immunity for insect pests and disease vectors, as well as for mammals.},
keywords = {Animals, Gene Expression Regulation, Host-Pathogen Interactions, imler, Immunity, Innate, M3i, RNA Viruses, Signal Transduction},
pubstate = {published},
tppubtype = {article}
}
2009
Kemp Cordula, Imler Jean-Luc
Antiviral immunity in drosophila Journal Article
In: Current Opinion in Immunology, vol. 21, no. 1, pp. 3–9, 2009, ISSN: 1879-0372.
Abstract | Links | BibTeX | Tags: Animals, Argonaute Proteins, Caspases, DEAD-box RNA Helicases, Evolution, Gene Expression Regulation, Host-Pathogen Interactions, imler, M3i, Membrane Proteins, Molecular, Nuclear Proteins, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Virus Infections, RNA Viruses, RNA-Induced Silencing Complex, Viral, Virulence
@article{kemp_antiviral_2009,
title = {Antiviral immunity in drosophila},
author = {Cordula Kemp and Jean-Luc Imler},
doi = {10.1016/j.coi.2009.01.007},
issn = {1879-0372},
year = {2009},
date = {2009-02-01},
journal = {Current Opinion in Immunology},
volume = {21},
number = {1},
pages = {3--9},
abstract = {Genetic analysis of the drosophila antiviral response indicates that RNA interference plays a major role. This contrasts with the situation in mammals, where interferon-induced responses mediate innate antiviral host-defense. An inducible response also contributes to antiviral immunity in drosophila, and similarities in the sensing and signaling of viral infection are becoming apparent between drosophila and mammals. In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals.},
keywords = {Animals, Argonaute Proteins, Caspases, DEAD-box RNA Helicases, Evolution, Gene Expression Regulation, Host-Pathogen Interactions, imler, M3i, Membrane Proteins, Molecular, Nuclear Proteins, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Virus Infections, RNA Viruses, RNA-Induced Silencing Complex, Viral, Virulence},
pubstate = {published},
tppubtype = {article}
}
2008
Huszar Tünde, Imler Jean-Luc
Drosophila viruses and the study of antiviral host-defense Journal Article
In: Advances in Virus Research, vol. 72, pp. 227–265, 2008, ISSN: 0065-3527.
Abstract | Links | BibTeX | Tags: Animals, Host-Pathogen Interactions, imler, Immunity, Innate, Insect Viruses, M3i, RNA Interference, RNA Viruses
@article{huszar_drosophila_2008,
title = {Drosophila viruses and the study of antiviral host-defense},
author = {Tünde Huszar and Jean-Luc Imler},
doi = {10.1016/S0065-3527(08)00406-5},
issn = {0065-3527},
year = {2008},
date = {2008-01-01},
journal = {Advances in Virus Research},
volume = {72},
pages = {227--265},
abstract = {The fruit fly Drosophila melanogaster is a powerful model to study host-pathogen interactions. Most studies so far have focused on extracellular pathogens such as bacteria and fungi. More recently, viruses have come to the front, and RNA interference was shown to play a critical role in the control of viral infections in drosophila. We review here our current knowledge on drosophila viruses. A diverse set of RNA viruses belonging to several families (Rhabdoviridae, Dicistroviridae, Birnaviridae, Reoviridae, Errantiviridae) has been reported in D. melanogaster. By contrast, no DNA virus has been recovered up to now. The drosophila viruses represent powerful tools to study virus-cell interactions in vivo. Analysis of the literature however reveals that for many of them, important gaps exist in our understanding of their replication cycle, genome organization, morphology or pathogenesis. The data obtained in the past few years on antiviral defense mechanisms in drosophila, which point to evolutionary conserved pathways, highlight the potential of the D. melanogaster model to study antiviral innate immunity and to better understand the complex interaction between arthropod-borne viruses and their insect vectors.},
keywords = {Animals, Host-Pathogen Interactions, imler, Immunity, Innate, Insect Viruses, M3i, RNA Interference, RNA Viruses},
pubstate = {published},
tppubtype = {article}
}
2006
Galiana-Arnoux Delphine, Dostert Catherine, Schneemann Anette, Hoffmann Jules A, Imler Jean-Luc
Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila Journal Article
In: Nature Immunology, vol. 7, no. 6, pp. 590–597, 2006, ISSN: 1529-2908.
Abstract | Links | BibTeX | Tags: Animals, Genetically Modified, hoffmann, imler, M3i, Mutation, Nodaviridae, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Viruses, Viral, Viral Proteins, Virus Replication
@article{galiana-arnoux_essential_2006,
title = {Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila},
author = {Delphine Galiana-Arnoux and Catherine Dostert and Anette Schneemann and Jules A Hoffmann and Jean-Luc Imler},
doi = {10.1038/ni1335},
issn = {1529-2908},
year = {2006},
date = {2006-06-01},
journal = {Nature Immunology},
volume = {7},
number = {6},
pages = {590--597},
abstract = {The fruit fly Drosophila melanogaster is a model system for studying innate immunity, including antiviral host defense. Infection with drosophila C virus triggers a transcriptional response that is dependent in part on the Jak kinase Hopscotch. Here we show that successful infection and killing of drosophila with the insect nodavirus flock house virus was strictly dependent on expression of the viral protein B2, a potent inhibitor of processing of double-stranded RNA mediated by the essential RNA interference factor Dicer. Conversely, flies with a loss-of-function mutation in the gene encoding Dicer-2 (Dcr-2) showed enhanced susceptibility to infection by flock house virus, drosophila C virus and Sindbis virus, members of three different families of RNA viruses. These data demonstrate the importance of RNA interference for controlling virus replication in vivo and establish Dcr-2 as a host susceptibility locus for virus infections.},
keywords = {Animals, Genetically Modified, hoffmann, imler, M3i, Mutation, Nodaviridae, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Viruses, Viral, Viral Proteins, Virus Replication},
pubstate = {published},
tppubtype = {article}
}