Publications
2008
Marzi S, Fechter P, Chevalier C, Romby P, Geissmann T
RNA switches regulate initiation of translation in bacteria Journal Article
In: Biol Chem, vol. 389, no. 5, pp. 585-598, 2008, ISBN: 18953726, (1431-6730 (Print) Journal Article Research Support, Non-U.S. Gov't Review).
Abstract | Links | BibTeX | Tags: Animals Bacteria/*genetics Genes, Bacterial/genetics/*immunology RNA, Messenger/biosynthesis/genetics Ribosomes/immunology, ROMBY, Switch/genetics/*immunology Humans Peptide Chain Initiation, Translational/genetics/*immunology Protein Biosynthesis/genetics/*immunology RNA, Unité ARN
@article{,
title = {RNA switches regulate initiation of translation in bacteria},
author = {S Marzi and P Fechter and C Chevalier and P Romby and T Geissmann},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18953726},
isbn = {18953726},
year = {2008},
date = {2008-01-01},
journal = {Biol Chem},
volume = {389},
number = {5},
pages = {585-598},
abstract = {A large variety of RNA-based mechanisms have been uncovered in all living organisms to regulate gene expression in response to internal and external changes, and to rapidly adapt cell growth in response to these signals. In bacteria, structural elements in the 5' leader regions of mRNAs have direct effects on translation initiation of the downstream coding sequences. The docking and unfolding of these mRNAs on the 30S subunit are critical steps in the initiation process directly modulating and timing translation. Structural elements can also undergo conformational changes in response to environmental cues (i.e., temperature sensors) or upon binding of a variety of trans-acting factors, such as metabolites, non-coding RNAs or regulatory proteins. These RNA switches can temporally regulate translation, leading either to repression or to activation of protein synthesis.},
note = {1431-6730 (Print)
Journal Article
Research Support, Non-U.S. Gov't
Review},
keywords = {Animals Bacteria/*genetics Genes, Bacterial/genetics/*immunology RNA, Messenger/biosynthesis/genetics Ribosomes/immunology, ROMBY, Switch/genetics/*immunology Humans Peptide Chain Initiation, Translational/genetics/*immunology Protein Biosynthesis/genetics/*immunology RNA, Unité ARN},
pubstate = {published},
tppubtype = {article}
}
A large variety of RNA-based mechanisms have been uncovered in all living organisms to regulate gene expression in response to internal and external changes, and to rapidly adapt cell growth in response to these signals. In bacteria, structural elements in the 5' leader regions of mRNAs have direct effects on translation initiation of the downstream coding sequences. The docking and unfolding of these mRNAs on the 30S subunit are critical steps in the initiation process directly modulating and timing translation. Structural elements can also undergo conformational changes in response to environmental cues (i.e., temperature sensors) or upon binding of a variety of trans-acting factors, such as metabolites, non-coding RNAs or regulatory proteins. These RNA switches can temporally regulate translation, leading either to repression or to activation of protein synthesis.