RNA interference and receptors

@article{marangon_covalent_2014,

title = {Covalent Functionalization of Multi-walled Carbon Nanotubes with a Gadolinium Chelate for Efficient T1-Weighted Magnetic Resonance Imaging},

author = {Iris Marangon and Cécilia Ménard‐Moyon and Jelena Kolosnjaj‐Tabi and Marie Lys Béoutis and Lénaic Lartigue and Damien Alloyeau and Elzbieta Pach and Belén Ballesteros and Gwennhael Autret and Tsedev Ninjbadgar and Dermot F Brougham and Alberto Bianco and Florence Gazeau},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201402234},

doi = {10.1002/adfm.201402234},

issn = {1616-3028},

year  = {2014},

date = {2014-01-01},

urldate = {2020-04-02},

journal = {Advanced Functional Materials},

volume = {24},

number = {45},

pages = {7173--7186},

abstract = {Given the promise of carbon nanotubes (CNTs) for photothermal therapy, drug delivery, tissue engineering, and gene therapy, there is a need for non-invasive imaging methods to monitor CNT distribution and fate in the body. In this study, non-ionizing whole-body high field magnetic resonance imaging (MRI) is used to follow the distribution of water-dispersible non-toxic functionalized CNTs administrated intravenously to mice. Oxidized CNTs are endowed with positive MRI contrast properties by covalent functionalization with the chelating ligand diethylenetriaminepentaacetic dianhydride (DTPA), followed by chelation to Gd3+. The structural and magnetic properties, MR relaxivities, cellular uptake, and application for MRI cell imaging of Gd-CNTs in comparison to the precursor oxidized CNTs are evaluated. Despite the intrinsic T2 contrast of oxidized CNTs internalized in macrophages, the anchoring of paramagnetic gadolinium onto the nanotube sidewall allows efficient T1 contrast and MR signal enhancement, which is preserved after CNT internalization by cells. Hence, due to their high dispersibility, Gd-CNTs have the potential to produce positive contrast in vivo following injection into the bloodstream. The uptake of Gd-CNTs in the liver and spleen is assessed using MRI, while rapid renal clearance of extracellular Gd-CNTs is observed, confirming the evidences of other studies using different imaging modalities.},

keywords = {Carbon nanotubes, contrast agents, I2CT, magnetic resonance imaging, Nanomedicine, Team-Bianco},

pubstate = {published},

tppubtype = {article}

}