RNA interference and receptors

@article{lacerda_intracellular_2007,

title = {Intracellular Trafficking of Carbon Nanotubes by Confocal Laser Scanning Microscopy},

author = {L Lacerda and G Pastorin and D Gathercole and J Buddle and M Prato and A Bianco and K Kostarelos},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.200790051},

doi = {10.1002/adma.200790051},

issn = {1521-4095},

year  = {2007},

date = {2007-01-01},

urldate = {2020-03-31},

journal = {Advanced Materials},

volume = {19},

number = {14},

pages = {1789--1789},

keywords = {Biomedical materials, Cells, Drug delivery, fluorescence, I2CT, Nanotubes, single-walled, Team-Bianco},

pubstate = {published},

tppubtype = {article}

}

@article{lacerda_luminescence_2006,

title = {Luminescence of Functionalized Carbon Nanotubes as a Tool to Monitor Bundle Formation and Dissociation in Water: The Effect of Plasmid-DNA Complexation},

author = {L Lacerda and G Pastorin and W Wu and M Prato and A Bianco and K Kostarelos},

url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.200500569},

doi = {10.1002/adfm.200500569},

issn = {1616-3028},

year  = {2006},

date = {2006-01-01},

urldate = {2020-03-31},

journal = {Advanced Functional Materials},

volume = {16},

number = {14},

pages = {1839--1846},

abstract = {Functionalized carbon nanotubes (f-CNTs) are explored as novel nanomaterials for biomedical applications. UV-vis luminescence of aqueous dispersions of CNT–NH3+ and CNT–NH–Ac (NH–Ac: acetamido) is observed using standard laboratory spectrophotometric instrumentation, and the measured fluorescence intensity is correlated with the aggregation state of the f-CNTs: a high intensity indicates improved f-CNT individualization and dispersion, while a decrease in fluorescence intensity indicates a higher degree of nanotube aggregation and bundling as a result of varying the sodium dodecyl sulfate (SDS) concentrations and pH in the aqueous phase. Moreover, utilization of this relationship between fluorescence intensity and the state of f-CNT aggregation is carried out to elucidate the interactions between f-CNTs and gene-encoding plasmid DNA (pDNA). pDNA is shown to interact with CNT–NH3+ primarily through electrostatic interactions that lead concomitantly to a higher degree of f-CNT bundling. The CNT–NH3+/pDNA interactions are successfully competed by SDS/f-CNT surface interactions, resulting in the displacement of pDNA. These studies provide exemplification of the use of fluorescence spectrophotometry to accurately describe the aggregation state of water-soluble f-CNTs. Characterization of the complexes between pDNA and f-CNTs elucidates the opportunities and limitations of such supramolecular systems as potential vectors for gene transfer.},

keywords = {Carbon nanotubes, DNA, I2CT, Luminescence, multiwalled, single-walled, Team-Bianco},

pubstate = {published},

tppubtype = {article}

}