RNA interference and receptors

@article{monneaux_molecular_2009,

title = {Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects},

author = {Fanny Monneaux and Sylviane Muller},

doi = {10.1186/ar2711},

issn = {1478-6362},

year  = {2009},

date = {2009-01-01},

journal = {Arthritis Research & Therapy},

volume = {11},

number = {3},

pages = {234},

abstract = {The prognosis of patients with systemic lupus erythematosus has greatly improved since treatment regimens combining corticosteroids and immunosuppressive medications have been widely adopted in therapeutic strategies given to these patients. Immune suppression is evidently efficient but also leads to higher susceptibility to infectious and malignant diseases. Toxic effects and sometimes unexpectedly dramatic complications of current therapies have been progressively reported. Identifying novel molecular targets therefore remains an important issue in the treatment of lupus. The aim of this review article is to highlight emerging pharmacological options and new therapeutic avenues for lupus with a particular focus on non-antibody molecular strategies.},

keywords = {Animals, Clinical Trials as Topic, Forecasting, Genetic Therapy, Humans, I2CT, Lupus Erythematosus, Monneaux, Systemic, Team-Dumortier},

pubstate = {published},

tppubtype = {article}

}

@article{martinelli_evolution_2005,

title = {Evolution and integration of innate immune systems from fruit flies to man: lessons and questions},

author = {Cosimo Martinelli and Jean-Marc Reichhart},

doi = {10.1179/096805105X37411},

issn = {0968-0519},

year  = {2005},

date = {2005-01-01},

journal = {J. Endotoxin Res.},

volume = {11},

number = {4},

pages = {243--248},

abstract = {Despite broad differences in morphology, ecology and behavior, the fruit fly Drosophila melanogaster and humans show a remarkably high degree of conservation for many molecular, cellular, and developmental aspects of their biology. During the last decade, similarities have also been discovered in some of the mechanisms regulating their innate immune system. These parallels regard mainly the Toll-like receptor family and the intracellular signaling pathways involved in the control of the immune response. However, if the overall similarities are important, the detailed pathogen recognition mechanisms differ significantly between fly and humans, highlighting a complicated evolutionary history of the metazoan innate defenses. In this review, we will discuss the main similarities and differences between the two types of organisms. We hope that this current knowledge will be used as a starting point for a more comprehensive view of innate immunity within the broad variety of metazoan phyla.},

keywords = {Animals, Biological Evolution, Cell Surface, Forecasting, Humans, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors},

pubstate = {published},

tppubtype = {article}

}