In humans, the inflammatory response when deregulated can lead to the onset of chronic inflammatory diseases and the development of cancer. The development of molecules capable of interfering with the abnormal activation of the NF-kB pathways, without the toxic effects inherent in the anti-inflammatories currently used, is inseparable from a better understanding of the NF-kB signaling pathways and their operations. Also the objective of our group is to decode the NF-kB pathways in order to understand their regulatory mechanisms. To do this, we use genetics and proteomics approaches adapted to the Drosophila model and to human cell cultures.
We work on 3 main axes whose objectives are:
– Understand the role of non-coding RNAs in the immune response.
– Understand how the transcriptional selectivity of NF-kB factors operates
– Study the regulation of the IMD pathway
To this end, our team collaborates in particular with the groups of Prof. Osmua Tackeuhi (University of Kyoto, Kyoto, Japan), Prof. Amir Orian (Technion, Haifia, Israel), Dr Marie-Odile Fauvarque (CEA, Grenoble, France) and by Dr Angela Giangrande (IGBMC, Illkirch, France).
Understand the role of non-coding RNAs in the immune response.
Understand how the transcriptional selectivity of NF-kB factors operates
Study the regulation of the IMD pathway
Florian Veillard, Laurent Troxler, Jean-Marc Reichhart: Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. In: Biochimie, 122, p. 255-269, 2015, ISBN: 0300-9084.
Laure El Chamy, Nicolas Matt, Monde Ntwasa, Jean-Marc Reichhart: The multilayered innate immune defense of the gut. In: Biomed J, 38 (4), p. 276–284, 2015, ISSN: 2320-2890.
Our work is supported by :