The project of this group is aimed at understanding the process of inflammation using Drosophila as a model. Two lines of research will be taken: 1) the caracterisation of the interactions between the components of the IMD pathway at the molecular and biochemical level and 2) the exploration of the phenotypes of known loss of function mutants for DNAse II and DDR2 that result in an inflammatory phenotype. The relationships between stress response and protein homeostasis will also be explored by the investigation of the effect of polyglutamine-containing protein accumulation that are found in Alzheimer disease fly models.
Several recent observations suggest that the Imd pathway, which we originally described for its role in defenses against Gram-negative bacteria, is involved in the inflammatory response in Drosophila.
Our research project focuses on inflammatory reactions with the aim of establishing Drosophila as a model for studying inflammation, which is currently one of the major health problems.