Publications
2023
Huang Jianqiong, Lou Yanyan, Liu Jiyong, Bulet Philippe, Cai Chuping, Ma Kaiyu, Jiao Renjie, Hoffmann Jules A, Liégeois Samuel, Lia Zi, Ferrandon Dominique
A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium Journal Article
In: PNAS, vol. 120, no. 12, 2023.
Abstract | Links | BibTeX | Tags: Baramicin A, Destruxin A, disease tolerance, enterocin O16, ferrandon, hoffmann, M3i, microbial toxins, resilience
@article{Huang2023,
title = {A Toll pathway effector protects Drosophila specifically from distinct toxins secreted by a fungus or a bacterium},
author = {Jianqiong Huang and Yanyan Lou and Jiyong Liu and Philippe Bulet and Chuping Cai and Kaiyu Ma and Renjie Jiao and Jules A Hoffmann and Samuel Liégeois and Zi Lia and Dominique Ferrandon},
editor = {Hugo Bellen, Baylor College of Medicine, Houston, TX},
url = {https://doi.org/10.1073/pnas.2205140120},
doi = {10.1073/pnas.2205140120},
year = {2023},
date = {2023-03-14},
urldate = {2023-03-14},
journal = {PNAS},
volume = {120},
number = {12},
abstract = {Major immune response pathways control the expression of hundreds of genes that represent potential effectors of the immune response. The Drosophila Toll pathway is required in the host defenses against several Gram-positive bacterial infections as well as against fungal infections. The current paradigm is that peptides secreted in the hemolymph during the systemic immune response are either bona fide antimicrobial peptides or likely ones. The finding of a dual role for one Toll pathway effector in the resilience to both Enterococcus faecalis and Metarhizium robertsii infections underscores an original concept in insect innate immunity. Evolution can select effectors tailored to protect the host from the action of microbial toxins of prokaryotic or eukaryotic origin, independently of antibodies or detoxification pathways.},
keywords = {Baramicin A, Destruxin A, disease tolerance, enterocin O16, ferrandon, hoffmann, M3i, microbial toxins, resilience},
pubstate = {published},
tppubtype = {article}
}
Major immune response pathways control the expression of hundreds of genes that represent potential effectors of the immune response. The Drosophila Toll pathway is required in the host defenses against several Gram-positive bacterial infections as well as against fungal infections. The current paradigm is that peptides secreted in the hemolymph during the systemic immune response are either bona fide antimicrobial peptides or likely ones. The finding of a dual role for one Toll pathway effector in the resilience to both Enterococcus faecalis and Metarhizium robertsii infections underscores an original concept in insect innate immunity. Evolution can select effectors tailored to protect the host from the action of microbial toxins of prokaryotic or eukaryotic origin, independently of antibodies or detoxification pathways.